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Colour Doppler ultrasound of the ocular circulation in patients with systemic lupus erythematosus identifies altered microcirculatory haemodynamics

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Název: Colour Doppler ultrasound of the ocular circulation in patients with systemic lupus erythematosus identifies altered microcirculatory haemodynamics
Autoři: Wright, S.A., O'Prey, F.M., Hamilton, P.K., Lockhart, C.J., Plumb, R., McVeigh, G.E., McHenry, M.T., Finch, M.B., Bell, A.L., McCann, A., McGivern, R.C.
Zdroj: Wright, S A, O'Prey, F M, Hamilton, P K, Lockhart, C J, Plumb, R, McVeigh, G E, McHenry, M T, Finch, M B, Bell, A L, McCann, A & McGivern, R C 2009, 'Colour Doppler ultrasound of the ocular circulation in patients with systemic lupus erythematosus identifies altered microcirculatory haemodynamics', Lupus, vol. 18, no. 11, pp. 950-957. https://doi.org/10.1177/0961203309104865
Rok vydání: 2009
Sbírka: Queen's University Belfast: Research Portal
Témata: Adult, Algorithms, Eye/blood supply, Female, Hemodynamics/physiology, Humans, Lupus Erythematosus, Systemic/blood, Microcirculation/physiology, Middle Aged, Ophthalmic Artery/diagnostic imaging, Regional Blood Flow/physiology, Retinal Artery/diagnostic imaging, Ultrasonography, Doppler, Color
Popis: We assessed whether quantitative analysis of Doppler flow velocity waveforms is able to identify subclinical microvascular abnormalities in SLE and whether eigenvector analysis can detect changes not detectable using the resistive index (RI). Fifty-four SLE patients with no conventional cardiovascular risk factors, major organ involvement or retinopathy were compared to 32 controls. Flow velocity waveforms were obtained from the ophthalmic artery (OA), central retinal artery (CRA) and common carotid artery (CA). The waveforms were analysed using eigenvector decomposition and compared between groups at each arterial site. The RI was also determined. The RI was comparable between groups. In the OA and CRA, there were significant differences in the lower frequency sinusoidal components (P < 0.05 for each component). No differences were apparent in the CA between groups. Eigenvector analysis of Doppler flow waveforms, recorded in proximity of the terminal vascular bed, identified altered ocular microvascular haemodynamics in SLE. Altered waveform structure could not be identified by changes in RI, the traditional measure of downstream vascular resistance. This analytical approach to waveform analysis is more sensitive in detecting preclinical microvascular abnormalities in SLE. It may hold potential as a useful tool for assessing disease activity, response to treatment, and predicting future vascular complications.
Druh dokumentu: article in journal/newspaper
Jazyk: English
DOI: 10.1177/0961203309104865
Dostupnost: https://pure.qub.ac.uk/en/publications/23a7285d-477e-411f-8c8e-3fc05cc237a5
https://doi.org/10.1177/0961203309104865
Rights: info:eu-repo/semantics/openAccess
Přístupové číslo: edsbas.3B8C82A6
Databáze: BASE
Popis
Abstrakt:We assessed whether quantitative analysis of Doppler flow velocity waveforms is able to identify subclinical microvascular abnormalities in SLE and whether eigenvector analysis can detect changes not detectable using the resistive index (RI). Fifty-four SLE patients with no conventional cardiovascular risk factors, major organ involvement or retinopathy were compared to 32 controls. Flow velocity waveforms were obtained from the ophthalmic artery (OA), central retinal artery (CRA) and common carotid artery (CA). The waveforms were analysed using eigenvector decomposition and compared between groups at each arterial site. The RI was also determined. The RI was comparable between groups. In the OA and CRA, there were significant differences in the lower frequency sinusoidal components (P < 0.05 for each component). No differences were apparent in the CA between groups. Eigenvector analysis of Doppler flow waveforms, recorded in proximity of the terminal vascular bed, identified altered ocular microvascular haemodynamics in SLE. Altered waveform structure could not be identified by changes in RI, the traditional measure of downstream vascular resistance. This analytical approach to waveform analysis is more sensitive in detecting preclinical microvascular abnormalities in SLE. It may hold potential as a useful tool for assessing disease activity, response to treatment, and predicting future vascular complications.
DOI:10.1177/0961203309104865