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Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood.

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Název: Spatial navigation training protects the hippocampus against age-related changes during early and late adulthood.
Autoři: Lövdén, Martin, Schaefer, Sabine, Noack, Hannes, Bodammer, Nils Christian, Kühn, Simone, Heinze, Hans-Jochen, Düzel, Emrah, Bäckman, Lars, Lindenberger, Ulman
Zdroj: Neurobiology of aging 33(3), 620.e9-620.e22 (2012). doi:10.1016/j.neurobiolaging.2011.02.013
Informace o vydavateli: Elsevier Science
Rok vydání: 2012
Témata: info:eu-repo/classification/ddc/610, Adult, Age Factors, Aged, Aging: pathology, Aging: psychology, Exercise Therapy: instrumentation, Exercise Therapy: methods, Female, Hippocampus: pathology, Hippocampus: physiopathology, Humans, Male, Memory Disorders: physiopathology, Memory Disorders: prevention & control, Memory Disorders: therapy, Middle Aged, User-Computer Interface, Young Adult
Geografické téma: DE
Popis: It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed by a return to baseline in the right hippocampus, but declined in the control groups and in the left hippocampus. We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline. These results provide the first longitudinal evidence indicating that spatial navigation experience modifies hippocampal volumes in humans, and confirm epidemiological results suggesting that mental stimulation may have direct effects on neural integrity.
Druh dokumentu: article in journal/newspaper
Jazyk: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/pmid:21497950; info:eu-repo/semantics/altIdentifier/issn/1558-1497; info:eu-repo/semantics/altIdentifier/issn/0197-4580; https://pub.dzne.de/record/136421
Dostupnost: https://pub.dzne.de/record/136421
https://pub.dzne.de/search?p=id:%22DZNE-2020-02743%22
Rights: info:eu-repo/semantics/openAccess
Přístupové číslo: edsbas.2A33D6B6
Databáze: BASE
Popis
Abstrakt:It is unknown whether lifestyle, including mental stimulation, and appropriate training interventions, may directly improve spatial navigation performance and its underlying neural substrates. Here we report that healthy younger and older men performing a cognitively demanding spatial navigation task every other day over 4 months display navigation-related gains in performance and stable hippocampal volumes that were maintained 4 months after termination of training. In contrast, control groups displayed volume decrements consistent with longitudinal estimates of age-related decline. Hippocampal barrier density, as indicated by mean diffusivity estimated from diffusion tensor imaging, showed a quadratic shape of increased density after training followed by a return to baseline in the right hippocampus, but declined in the control groups and in the left hippocampus. We conclude that sustained experiential demands on spatial ability protect hippocampal integrity against age-related decline. These results provide the first longitudinal evidence indicating that spatial navigation experience modifies hippocampal volumes in humans, and confirm epidemiological results suggesting that mental stimulation may have direct effects on neural integrity.