Health-related quality of life and self-reported cognitive function in patients with delayed neurocognitive recovery after radical prostatectomy: a prospective follow-up study
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| Název: | Health-related quality of life and self-reported cognitive function in patients with delayed neurocognitive recovery after radical prostatectomy: a prospective follow-up study |
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| Autoři: | Kahl, Ursula, Callsen, Sarah, Beck, Stefanie, Pinnschmidt, Hans, von Breunig, Franziska, Haese, Alexander, Graefen, Markus, Zöllner, Christian, Fischer, Marlene |
| Zdroj: | http://lobid.org/resources/99370677071306441#!, 19(1):64. |
| Rok vydání: | 2021 |
| Sbírka: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| Témata: | Cognition/physiology [MeSH], Surveys and Questionnaires [MeSH], Prostatectomy/adverse effects [MeSH], Follow-Up Studies [MeSH], Postoperative Complications [MeSH], Aged [MeSH], Self Report [MeSH], Humans [MeSH], Prospective Studies [MeSH], Quality of Life/psychology [MeSH], Middle Aged [MeSH], Radical prostatectomy, Postoperative cognitive dysfunction, Quality of life, Male [MeSH], Prostatectomy/rehabilitation [MeSH], Research, Prostatic Neoplasms/psychology [MeSH], Delayed neurocognitive recovery, Prostatic Neoplasms/surgery [MeSH], Cognitive failures, Prostate cancer |
| Popis: | Background!#!Delayed neurocognitive recovery (DNCR) is a common and serious complication after radical prostatectomy. We hypothesized that patients with DNCR in the early postoperative period would report reduced health-related quality of life (HRQoL) and more cognitive failures 12 months after surgery, compared with patients without DNCR.!##!Methods!#!We performed a 12-month follow-up on 367 patients who had been enrolled in a prospective observational trial to study the incidence of DNCR after radical prostatectomy. Patients were screened for preoperative cognitive impairment and depression. We defined DNCR as a decline in cognitive function between days 3 and 5 after surgery, compared with baseline assessments. We evaluated HRQoL and cognitive failures 12 months after surgery with the 36-item Short Form Health Survey and the Cognitive Failures Questionnaire. General linear models were used to analyze associations of DNCR with HRQoL and cognitive failures.!##!Results!#!Delayed neurocognitive recovery in the early postoperative period was significantly associated with self-reported cognitive failures (B for no DNCR = - 0.411 [95% CI: - 0.798;0.024], p = 0.038), but not with physical (B = 0.082 [95% CI: - 0.021;0.186], p = 0.118) or mental HRQoL (B = - 0.044 [95% CI: - 0.149;0.062], p = 0.417) 12 months after surgery. Preoperative depression screening scores were significantly associated with self-reported cognitive failures and both physical and mental HRQoL 12 months after surgery.!##!Conclusions!#!Delayed neurocognitive recovery in the early period after radical prostatectomy has a long-term impact on patients' daily lives by impairing memory, attention, action, and perception. Therefore, prevention of DNCR must be a priority for physicians and researchers. Consequent preoperative screening for depressive symptoms may facilitate early psycho-oncological intervention to improve postoperative HRQoL. Trials registration DRKS00010014 , date of registration: 21.03.2016, retrospectively registered. |
| Druh dokumentu: | article in journal/newspaper |
| Jazyk: | English |
| ISBN: | 978-9937-0-6770-6 9937-0-6770-7 |
| Relation: | https://repository.publisso.de/resource/frl:6463365; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908756/ |
| DOI: | 10.1186/s12955-021-01705-z |
| Dostupnost: | https://repository.publisso.de/resource/frl:6463365 https://doi.org/10.1186/s12955-021-01705-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908756/ |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Přístupové číslo: | edsbas.24252FF |
| Databáze: | BASE |
Nájsť tento článok vo Web of Science | Abstrakt: | Background!#!Delayed neurocognitive recovery (DNCR) is a common and serious complication after radical prostatectomy. We hypothesized that patients with DNCR in the early postoperative period would report reduced health-related quality of life (HRQoL) and more cognitive failures 12 months after surgery, compared with patients without DNCR.!##!Methods!#!We performed a 12-month follow-up on 367 patients who had been enrolled in a prospective observational trial to study the incidence of DNCR after radical prostatectomy. Patients were screened for preoperative cognitive impairment and depression. We defined DNCR as a decline in cognitive function between days 3 and 5 after surgery, compared with baseline assessments. We evaluated HRQoL and cognitive failures 12 months after surgery with the 36-item Short Form Health Survey and the Cognitive Failures Questionnaire. General linear models were used to analyze associations of DNCR with HRQoL and cognitive failures.!##!Results!#!Delayed neurocognitive recovery in the early postoperative period was significantly associated with self-reported cognitive failures (B for no DNCR = - 0.411 [95% CI: - 0.798;0.024], p = 0.038), but not with physical (B = 0.082 [95% CI: - 0.021;0.186], p = 0.118) or mental HRQoL (B = - 0.044 [95% CI: - 0.149;0.062], p = 0.417) 12 months after surgery. Preoperative depression screening scores were significantly associated with self-reported cognitive failures and both physical and mental HRQoL 12 months after surgery.!##!Conclusions!#!Delayed neurocognitive recovery in the early period after radical prostatectomy has a long-term impact on patients' daily lives by impairing memory, attention, action, and perception. Therefore, prevention of DNCR must be a priority for physicians and researchers. Consequent preoperative screening for depressive symptoms may facilitate early psycho-oncological intervention to improve postoperative HRQoL. Trials registration DRKS00010014 , date of registration: 21.03.2016, retrospectively registered. |
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| ISBN: | 9789937067706 9937067707 |
| DOI: | 10.1186/s12955-021-01705-z |