Ancient duplications and functional divergence in the interferon regulatory factors of vertebrates provide insights into the evolution of vertebrate immune systems
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| Titel: | Ancient duplications and functional divergence in the interferon regulatory factors of vertebrates provide insights into the evolution of vertebrate immune systems |
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| Autoren: | Du, Kang, Zhong, Zaixuan, Fang, Chengchi, Dai, Wei, Shen, Yanjun, Gan, Xiaoni, He, Shunping |
| Verlagsinformationen: | ELSEVIER SCI LTD |
| Publikationsjahr: | 2018 |
| Bestand: | Institute of Hydrobiology, Chinese Academy of Sciences: IHB OpenIR / 中国科学院水生生物研究所机构知识库 |
| Schlagwörter: | Interferon regulatory factor (IRF), Interferon (IFN), Adaptive immune system (AIS), Vertebrate immunity, Whole-genome duplication (WGD), Fisheries, Immunology, Zoology, CODON-SUBSTITUTION MODELS, AMINO-ACID SITES, TRANSCRIPTION FACTORS, ADAPTIVE IMMUNITY, CRYSTAL-STRUCTURE, GENE-EXPRESSION, SEA LAMPREY, IRF FAMILY, PROTEIN, IFN |
| Beschreibung: | Interferon regulatory factors (IRFs) were first discovered as transcription factors that regulate the transcription of human interferon (IFN)-beta. Increasing evidence shows that they might be important players involved in Adaptive immune system (AIS) evolution. Although numbers of IRFs have been identified in chordates, the evolutionary history and functional diversity of this gene family during the early evolution of vertebrates have remained obscure. Using IRF HMM profile and HMMER searches, we identified 148 IRFs in 11 vertebrates and 4 protochordates. For them, we reconstructed the phylogenetic relationships, determined the synteny conservation, investigated the profile of natural selection, and analyzed the expression patterns in four "living fossil" vertebrates: lamprey, elephant shark, coelacanth and bichir. The results from phylogeny and synteny analysis imply that vertebrate IRFs evolved from three predecessors, instead of four as suggested in a previous study, as results from an ancient duplication followed by special expansions and lost during the vertebrate evolution. The profile of natural selection and expression reveals functional dynamics during the process. Together, they suggest that the 2nd whole-genome duplication (2WGD) provided raw materials for innovation in the IRF family, and that the birth of type-I IFN might be an important factor inducing the establishment of IRF-mediated immune networks. As a member involved in the AIS evolution, IRF provide insights into the process and mechanism involved in the complexity and novelties of vertebrate immune systems. (C) 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. |
| Publikationsart: | report |
| Sprache: | English |
| Relation: | DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY; http://ir.ihb.ac.cn/handle/342005/29919; http://ir.ihb.ac.cn/handle/342005/29920 |
| DOI: | 10.1016/j.dci.2017.12.016 |
| Verfügbarkeit: | http://ir.ihb.ac.cn/handle/342005/29919 http://ir.ihb.ac.cn/handle/342005/29920 https://doi.org/10.1016/j.dci.2017.12.016 |
| Dokumentencode: | edsbas.1EBA6EB1 |
| Datenbank: | BASE |
Nájsť tento článok vo Web of Science | Abstract: | Interferon regulatory factors (IRFs) were first discovered as transcription factors that regulate the transcription of human interferon (IFN)-beta. Increasing evidence shows that they might be important players involved in Adaptive immune system (AIS) evolution. Although numbers of IRFs have been identified in chordates, the evolutionary history and functional diversity of this gene family during the early evolution of vertebrates have remained obscure. Using IRF HMM profile and HMMER searches, we identified 148 IRFs in 11 vertebrates and 4 protochordates. For them, we reconstructed the phylogenetic relationships, determined the synteny conservation, investigated the profile of natural selection, and analyzed the expression patterns in four "living fossil" vertebrates: lamprey, elephant shark, coelacanth and bichir. The results from phylogeny and synteny analysis imply that vertebrate IRFs evolved from three predecessors, instead of four as suggested in a previous study, as results from an ancient duplication followed by special expansions and lost during the vertebrate evolution. The profile of natural selection and expression reveals functional dynamics during the process. Together, they suggest that the 2nd whole-genome duplication (2WGD) provided raw materials for innovation in the IRF family, and that the birth of type-I IFN might be an important factor inducing the establishment of IRF-mediated immune networks. As a member involved in the AIS evolution, IRF provide insights into the process and mechanism involved in the complexity and novelties of vertebrate immune systems. (C) 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license. |
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| DOI: | 10.1016/j.dci.2017.12.016 |