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SARS-CoV-2 spike protein: Site-specific breakpoints for the development of COVID-19 vaccines

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Bibliographic Details
Title: SARS-CoV-2 spike protein: Site-specific breakpoints for the development of COVID-19 vaccines
Authors: Palaniyandi Velusamy, Kannan Kiruba, Chia-Hung Su, Viswanathan Arun, Periasamy Anbu, Subash C.B. Gopinath, Baskaralingam Vaseeharan
Source: Journal of King Saud University: Science, Vol 33, Iss 8, Pp 101648- (2021)
Publisher Information: Elsevier
Publication Year: 2021
Collection: Directory of Open Access Journals: DOAJ Articles
Subject Terms: Coronavirus, SARS-CoV2, Spike Protein, Virus Entry, Vaccine, Science (General), Q1-390
Description: SARS-CoV2 is a member of human coronaviruses and is the causative agent of the present pandemic COVID-19 virus. In order to control COVID-19, studies on viral structure and mechanism of infectivity and pathogenicity are sorely needed. The spike (S) protein is comprised of S1 & S2 subunits. These spike protein subunits enable viral attachment by binding to the host cell via ACE-2 (angiotensin converting enzyme-2) receptor, thus facilitating the infection. During viral entry, one of the key steps is the cleavage of the S1-S2 spike protein subunits via surface TMPRSS2 (transmembrane protease serine 2) and results in viral infection. Hence, the S-protein is critical for the viral attachment and penetration into the host. The rapid advancement of our knowledge on the structural and functional aspects of the spike protein could lead to development of numerous candidate vaccines against SARS-CoV2. Here the authors discuss about the structure of spike protein and explore its related functions. Our aim is to provide a better understanding that may aid in fighting against CoVID-19 and its treatment.
Document Type: article in journal/newspaper
Language: English
Relation: http://www.sciencedirect.com/science/article/pii/S1018364721003104; https://doaj.org/toc/1018-3647; https://doaj.org/article/907a1035deb849e6a0068053d678c154
DOI: 10.1016/j.jksus.2021.101648
Availability: https://doi.org/10.1016/j.jksus.2021.101648
https://doaj.org/article/907a1035deb849e6a0068053d678c154
Accession Number: edsbas.1DD12EDE
Database: BASE
Description
Abstract:SARS-CoV2 is a member of human coronaviruses and is the causative agent of the present pandemic COVID-19 virus. In order to control COVID-19, studies on viral structure and mechanism of infectivity and pathogenicity are sorely needed. The spike (S) protein is comprised of S1 & S2 subunits. These spike protein subunits enable viral attachment by binding to the host cell via ACE-2 (angiotensin converting enzyme-2) receptor, thus facilitating the infection. During viral entry, one of the key steps is the cleavage of the S1-S2 spike protein subunits via surface TMPRSS2 (transmembrane protease serine 2) and results in viral infection. Hence, the S-protein is critical for the viral attachment and penetration into the host. The rapid advancement of our knowledge on the structural and functional aspects of the spike protein could lead to development of numerous candidate vaccines against SARS-CoV2. Here the authors discuss about the structure of spike protein and explore its related functions. Our aim is to provide a better understanding that may aid in fighting against CoVID-19 and its treatment.
DOI:10.1016/j.jksus.2021.101648