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Prognostic value of stem cell line identification for renal cell carcinomas

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Název: Prognostic value of stem cell line identification for renal cell carcinomas
Autoři: Francois, Christine, Decaestecker, Christine, Salmon, Isabelle, Petein, Michel, Remmelink, Myriam, Janssen, Thierry, Wespes, Eric, Peltier, Alexandre, Schulman, Claude, Van Velthoven, Roland, Kiss, Robert
Zdroj: Analytical and quantitative cytology and histology. 20(3)
Informace o vydavateli: 1998.
Rok vydání: 1998
Témata: Renal Cell -- diagnosis, Adult, Male, 03 medical and health sciences, 0302 clinical medicine, Neoplastic Stem Cells -- chemistry, 80 and over, Tumor Cells, Cultured, Kidney Neoplasms -- pathology, Humans, Neoplasm Invasiveness, Kidney Neoplasms -- genetics, Renal Cell -- genetics, Carcinoma, Renal Cell, Aged, Aged, 80 and over, Cultured, Ploidies, Carcinoma, Renal Cell -- pathology, DNA, DNA, Neoplasm, Sciences bio-médicales et agricoles, Middle Aged, Prognosis, Kidney Neoplasms, Tumor Cells, Neoplastic Stem Cells -- pathology, Kidney Neoplasms -- diagnosis, Neoplasm -- diagnostic use, Renal Cell -- secondary, Neoplastic Stem Cells, Female
Popis: To investigate the prognostic value of nuclear DNA content (DNA ploidy level) in a series of 95 renal cell carcinomas (RCCs).Eight variables were used to characterize DNA ploidy levels. They included DNA index and seven others characterizing the presence of specific stem cell lines in each of the 95 RCCs under study. All these variables were determined by means of computer-assisted microscopy applied to Feulgen-stained nuclei. The actual information contributed by each of the eight variables was determined by means of univariate statistical analyses.The results showed that in the DNA ploidy-related eight variables, the presence of at least 4% aneuploid nuclei with > 5C DNA content was associated with the most significant prognostic value in RCCs with intermediate (T2, T3) invasion levels.The present study clearly showed that stem cell line characterization, and particularly the presence of highly aneuploid cells (with > 5C DNA content), is associated in RCCs with significant prognostic value. This kind of marker may help the identification of patients who will develop metastases after surgery and for whom adjuvant therapy might thus be indicated.
Druh dokumentu: Article
Popis souboru: 1 full-text file(s): application/pdf
Jazyk: English
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/9642448
Přístupové číslo: edsair.pmid.dedup....79c682735aebf9b98e1ec6f692359509
Databáze: OpenAIRE
Popis
Abstrakt:To investigate the prognostic value of nuclear DNA content (DNA ploidy level) in a series of 95 renal cell carcinomas (RCCs).Eight variables were used to characterize DNA ploidy levels. They included DNA index and seven others characterizing the presence of specific stem cell lines in each of the 95 RCCs under study. All these variables were determined by means of computer-assisted microscopy applied to Feulgen-stained nuclei. The actual information contributed by each of the eight variables was determined by means of univariate statistical analyses.The results showed that in the DNA ploidy-related eight variables, the presence of at least 4% aneuploid nuclei with > 5C DNA content was associated with the most significant prognostic value in RCCs with intermediate (T2, T3) invasion levels.The present study clearly showed that stem cell line characterization, and particularly the presence of highly aneuploid cells (with > 5C DNA content), is associated in RCCs with significant prognostic value. This kind of marker may help the identification of patients who will develop metastases after surgery and for whom adjuvant therapy might thus be indicated.