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Orální lichen planus - klinické a laboratorní parametry

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Bibliographic Details
Title: Orální lichen planus - klinické a laboratorní parametry
Authors: Radochová, Vladimíra
Contributors: Slezák, Radovan, Houbová, Helena, Kerekes, Zoltán
Publisher Information: 2014.
Publication Year: 2014
Subject Terms: 3. Good health
Description: in English - MUDr. Vladimíra Radochová Presented work deals in the first plase with clinical evaluation of patients with OLP regarding clinical presentation, gender, age and various clinical presentation of the disease. The necessity of the treatment and therapeutic approach is stressed as well. The following parts deal with systematic research of possible etiopathogenetic mechanisms of OLP. Research part is divided into chapters dealing with cytochrome P450 2D6 metabolism and drug use in patients with OLP. Further the importance of matrix metalloproteinase 9 in the development of OLP is discussed. The last part is focused on presence of HPV in OLP lesions. Demographic data of our cohort of patients are consistent with previously published data from around the world. Occurence of clinical forms, necessity of treatment are also in concordance with previously published data. Our data show the same metabolic rates of cytochrome P450 2D6 in patients with OLP compared to healthy Czech population. Drug use is similar to matched age and sex controls. We therefore were unable to confirm the role of different metabolic pathways in OLP. MMP 9 is higly expressed in OLP lesions. This probably represents general inflammatory process which takes part in OLP developement. We observe high positivity of HPV in OLP...
Document Type: Doctoral thesis
Language: Czech
Access URL: http://www.nusl.cz/ntk/nusl-338097
Accession Number: edsair.od......2186..6b3f0cf5cd690b1979e4cb1e719a37ba
Database: OpenAIRE
Description
Abstract:in English - MUDr. Vladimíra Radochová Presented work deals in the first plase with clinical evaluation of patients with OLP regarding clinical presentation, gender, age and various clinical presentation of the disease. The necessity of the treatment and therapeutic approach is stressed as well. The following parts deal with systematic research of possible etiopathogenetic mechanisms of OLP. Research part is divided into chapters dealing with cytochrome P450 2D6 metabolism and drug use in patients with OLP. Further the importance of matrix metalloproteinase 9 in the development of OLP is discussed. The last part is focused on presence of HPV in OLP lesions. Demographic data of our cohort of patients are consistent with previously published data from around the world. Occurence of clinical forms, necessity of treatment are also in concordance with previously published data. Our data show the same metabolic rates of cytochrome P450 2D6 in patients with OLP compared to healthy Czech population. Drug use is similar to matched age and sex controls. We therefore were unable to confirm the role of different metabolic pathways in OLP. MMP 9 is higly expressed in OLP lesions. This probably represents general inflammatory process which takes part in OLP developement. We observe high positivity of HPV in OLP...