Bibliographic Details
| Title: |
Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study |
| Authors: |
Jensen, Tomas O Murray, Thomas A Grandits, Greg A Jain, Mamta K Grund, Birgit Shaw-Saliba, Kathryn Matthay, Michael A Abassi, Mahsa Ardelt, Magdalena Baker, Jason V Chen, Peter Dewar, Robin L Goodman, Anna L Hatlen, Timothy J Highbarger, Helene C Holodniy, Mark Lallemand, Perrine Laverdure, Sylvain Leshnower, Bradley G Looney, David Moschopoulos, Charalampos D Mugerwa, Henry Murray, Daniel D Mylonakis, Eleftherios Nagy-Agren, Stephanie Rehman, M Tauseef Rupert, Adam Stevens, Randy Turville, Stuart Weintrob, Amy Wick, Katherine Lundgren, Jens Ko, Emily R Sahner, David Tierney, John Vogel, Susan E. Herpin, Betsey R. Smolskis, Mary C. McKay, Laura A. Cahill, Kelly Crew, Page Sardana, Ratna Raim, Sharon Segal Hensely, Lisa Lorenzo, Johsua Mock, Rebecca Zuckerman, Judith Atri, Negin Miller, Mark Vallee, David Chung, Lucy Kang, Nayon Barrett, Kevin Adam, Stacey J. Read, Sarah Draghia-Akli, Ruxandra Currier, Judy Hughes, Eric Harrigan, Rachel H. Amos, Laura Carlsen, Amy Carter, Anita Collins, Gary Davis, Bionca Denning, Eileen DuChene, Alain Eckroth, Kate Engen, Nicole Frase, Alex Gandits, Greg Harrison, Merrie Hurlbut, Nancy Kaiser, Payton Koopmeiners, Joseph Larson, Gregg Meger, Sue Mistry, Shweta Sharma Murray, Thomas Nelson, Ray Quan, Kien Quan, Siu Fun Reilly, Cavan Siegel, Lianne Thompson, Greg Vock, David Walski, Jamie Gelijns, Annetine C. Moskowitz, Alan J. Bagiella, Emilia Moquete, Ellen O'Sullivan, Karen Marks, Mary E. Accardi, Evan Kinzel, Emily Burris, Sarah Bedoya, Gabriela Gupta, Lola Overbey, Jessica R. Santos, Milerva Gillinov, Marc A. Miller, Marissa A. Taddei-Peters, Wendy C. Fenton, Kathleen Sandkovsky, Uriel Gottlieb, Robert L. Mack, Michael Berhe, Mezgebe Haley, Clinton Dishner, Emma Bettacchi, Christopher Golden, Kevin Duhaime, Erin Ryan, Madison Tallmadge, Catherine Estrada, Lorie Jones, Felecia Villa, Samatha Wang, Samatha Robert, Raven Coleman, Tanquinisha Clariday, Laura Baker, Rebecca Hurutado-Rodriguez, Mariana Iram, Nazia Fresnedo, Michelle Davis, Allyson Leonard, Kiara Ramierez, Noelia Thammavong, Jon Duque, Krizia Turner, Emma Fisher, Tammy Robinson, Dianna Ransom, Desirae Maldonado, Nicholas Lusk, Erica Killian, Aaron Palacious, Adriana Solis, Edilia Jerrow, Janet Watts, Matthew Whitacre, Heather Cothran, Elizabeth Smith, Peter K. Barkauskas, Christina E. Vekstein, Andrew M. Dreyer, Grace R. Stafford, Neil Brooks, Megan Der, Tatyana Witte, Marie Gamarallage, Ruwan Franzone, John Ivey, Noel Lumsden, Rebecca H. Mosaly, Nilima Mourad, Ahmaad Holland, Thomas L. Motta, Mary Lane, Kathleen McGowan, Lauren M. Stout, Jennifer Aloor, Heather Bragg, Kennesha M. Toledo, Barvina McLendon-Arvik, Beth Bussadori, Barbara Hollister, Beth A. Griffin, Michelle Giangiacomo, Dana M. Rodriguez, Vicente Bokhart, Gordon Eichman, Sharon M. Parrino, Patrick E. Spindel, Stephen Bansal, Aditya Baumgarten, Katherine Hand, Johnathan Vonderhaar, Derek Nossaman, Bobby Sylvia Laudun Ames, DeAnna Broussard, Shane Hernandez, Nilmo Isaac, Geralyn Dinh, Huan Zheng, Yiling Tran, Sonny McDaniel, Hunter Crovetto, Nicolle Perin, Emerson Costello, Briana Manian, Prasad Sohail, M. Rizwan Postalian, Alexander Hinsu, Punit Watson, Carolyn Chen, James Fink, Melyssa Sturgis, Lydia Walker, Kim Mahon, Kim Parenti, Jennifer Kappenman, Casey Knight, Aryn Sturek, Jeffrey M. Barros, Andrew Enfield, Kyle B. Kadl, Alexandra Green, China J. Simon, Rachel M. Fox, Ashley Thornton, Kara Adams, Amy Badhwar, Vinay Sharma, Sunil Peppers, Briana McCarthy, Paul Krupica, Troy Sarwari, Arif Reece, Rebecca Fornaresico, Lisa Glaze, Chad Evans, Raquel Di, Fang Carlson, Shawn Aucremanne, Tanja Tennant, Connie Sutton, Lisa Giblin Buterbaugh, Sabrina Williams, Roger Bunner, Robin Traverse, Jay H. Rhame, Frank Huelster, Joshua Kethireddy, Rajesh Davies, Irena Salamanca, Julianne Majeski, Christine Skelton, Paige Zarambo, Maria Sarafolean, Andrea Bowdish, Michael E. Borok, Zea Wald-Dickler, Noah Hutcheon, Douglass Towfighi, Amytis Lee, Mary Lewis, Meghan R. Spellberg, Brad Sher, Linda Sharma, Aniket Olds, Anna P. Justino, Chris Loxano, Edward Romero, Chris Leong, Janet Rodina, Valentina Quesada, Christine Hamilton, Luke Escobar, Jose Bender, William Sharifpour, Milad Miller, Jeffrey Farrington, Woodrow Baio, Kim T. McBride, Mary Fielding, Michele Mathewson, Sonya Porte, Kristina Maton, Missy Ponder, Chari Haley, Elisabeth Spainhour, Christine Rogers, Susan Tyler, Derrick Madathil, Ronson J. Rabin, Joseph Levine, Andrea Saharia, Kapil Tabatabai, Ali Lau, Christine Gammie, James S. Peguero, Maya-Loren McKernan, Kimberly Audette, Mathew Fleischmann, Emily Akbari, Kreshta Lee, Myounghee Chi, Andrew Salehi, Hanna Pariser, Alan Nyguyen, Phuong Tran Moore, Jessica Gee, Adrienne Vincent, Shelika Zuckerman, Richard A. Iribarne, Alexander Metzler, Sara Shipman, Samantha Johnson, Haley Newton, Crystallee Parr, Doug Miller, Leslie Schelle, Beth McLean, Sherry Rothbaum, Howard R. Alvarez, Michael S. Kalan, Shivam P. Germann, Heather H. Hendershot, Jennifer Moroney, Karen Herring, Karen Cook, Sharri Paul, Pam Walker-Ignasiak, Rebecca North, Crystal Oldmixon, Cathryn Ringwood, Nancy Muzikansky, Ariela Morse, Richard Fitzgerald, Laura Morin, Haley D. Brower, Roy G. Reineck, Lora A. Bienstock, Karen Steingrub, Jay H. Hou, Peter K. Steingrub, Jay S. Tidswell, Mark A. Kozikowski, Lori-Ann Kardos, Cynthia DeSouza, Leslie Romain, Sarah Thornton-Thompson, Sherell Talmor, Daniel Shapiro, Nathan Andromidas, Konstantinos Banner-Goodspeed, Valerie Bolstad, Michael Boyle, Katherine L. Cabrera, Payton deVilla, Arnaldo Ellis, Joshua C. Grafals, Ana Hayes, Sharon Higgins, Conor Kurt, Lisa Kurtzman, Nicholas Redman, Kimberly Rosseto, Elinita Scaffidi, Douglas Filbin, Michael R. Hibbert, Kathryn A. Parry, Blair Margolin, Justin Hillis, Brooklynn Hamer, Rhonda Brait, Kelsey Beakes, Caroline McKaig, Brenna Kugener, Eleonore Jones, Alan E. Galbraith, James Nandi, Utsav Peacock, Rebekah Hendey, Gregory Kangelaris, Kirsten Ashktorab, Kimia Gropper, Rachel Agrawal, Anika Yee, Kimberley J. Jauregui, Alejandra E. Zhuo, Hanjing Almasri, Eyad Fayed, Mohamed Hubel, Kinsley A. Hughes, Alyssa R. Garcia, Rebekah L. Lim, George W. Chang, Steven Y. Lin, Michael Y. Vargas, Julia Sihota, Hena Beutler, Rebecca Agarwal, Trisha Wilson, Jennifer G. Vojnik, Rosemary Perez, Cynthia McDowell, Jordan H. Roque, Jonasel Wang, Henry Huebinger, Ryan M. Patel, Bela Vidales, Elizabeth Albertson, Timothy Hardy, Erin Harper, Richart Moss, Marc A. Baduashvili, Amiran Chauhan, Lakshmi Douin, David J. Martinez, Flora Finck, Lani L. Bastman, Jill Howell, Michelle Higgins, Carrie McKeehan, Jeffrey Finigan, Jay Stubenrauch, Peter Janssen, William J. Griesmer, Christine VerBurg, Olivia Hyzy, Robert C. Park, Pauline K. Nelson, Kristine McSparron, Jake I. Co, Ivan N. Wang, Bonnie R. Jimenez, Jose Olbrich, Norman McDonough, Kelli Jia, Shijing Hanna, Sinan Gong, Michelle N. Richardson, Lynne D. Nair, Rahul Lopez, Brenda Amosu, Omowunmi Offor, Obiageli Tzehaie, Hiwet Nkemdirim, William Boujid, Sabah Mosier, Jarrod M. Hypes, Cameron Campbell, Elizabeth Salvagio Bixby, Billie Gilson, Boris Lopez, Anitza Bime, Christian Parthasarathy, Sairam Cano, Ariana M. Hite, R. Duncan Terndrup, Thomas E. Wiedemann, Herbert P. Hudock, Kristin Tanzeem, Hammad More, Harshada Martinkovic, Jamie Sellers, Susan Houston, Judy Burns, Mary Kiran, Simra Roads, Tammy Kennedy, Sarah Duggal, Abhijit Thiruchelvam, Nirosshan Ashok, Kiran King, Alexander H. Mehkri, Omar Dugar, Siddharth Sahoo, Debasis Yealy, Donald M. Angus, Derek C. Weissman, Alexandra J. Vita, Tina M. Berryman, Emily Hough, Catherine L. Khan, Akram Krol, Olivia F. Mills, Emmanuel Kinjal, Mistry Briceno, Genesis Reddy, Raju Hubel, Kinsley Jouzestani, Milad K. McDougal, Madeline Deshmukh, Rupali Johnston, Nicholas J. Robinson, Bryce H. Gundel, Staphanie J. Katsandres, Sarah C. Torbati, Sam S. Parimon, Tanyalak Caudill, Antonina Mattison, Brittany Jackman, Susan E. Chen, Po-En Bayoumi, Emad Ojukwu, Cristabelle Fine, Devin Weissberg, Gwendolyn Isip, Katherine Choi-Kuaea, Yunhee Mehdikhani, Shaunt Dar, Tahir B. Fleury Augustin, Nsole Biteghe Tran, Dana Dukov, Jennifer Emilow Matusov, Yuri Choe, June Hindoyan, Niree A. Wynter, Timothy Pascual, Ethan Clapham, Gregg J. Herrera, Lisa Caudill, Antonia O'Mahony, D. Shane Nyatsatsang, Sonam T. Wilson, David M. Wallick, Julie A. Duven, Alexandria M. Fletcher, Dakota D. Miller, Chadwick Files, D. Clark Gibbs, Kevin W. Flores, Lori S. LaRose, Mary E. Landreth, Leigha D. Palacios, D. Rafael Parks, Lisa Hicks, Madeline Goodwin, Andrew J. Kilb, Edward F. Lematty, Caitlan T. Patti, Kerilyn Grady, Abigail Rasberry, April Morris, Peter E. Sturgill, Jamie L. Cassity, Evan P. Dhar, Sanjay Montgomery-Yates, Ashley A. Pasha, Sarah N. Mayer, Kirby P. Pharm.D., Brittany Bissel Trott, Terren Rehman, Shahnaz de Wit, Marjolein Mason, Jessica Bledsoe, Joseph Knowlton, Kirk U. Brown, Samuel Lanspa, Michael Leither, Lindsey Pelton, Ithan Armbruster, Brent P. Montgomery, Quinn Kumar, Naresh Fergus, Melissa Imel, Karah Palmer, Ghazal Webb, Brandon Klippel, Carolyn Jensen, Hannah Duckworth, Sarah Gray, Andrew Burke, Tyler Knox, Dan Lumpkin, Jenna Aston, Valerie T. Applegate, Darrin Serezlic, Erna Brown, Katie Merril, Mardee Harris, Estelle S. Middleton, Elizabeth A. Barrios, Macy A.G. Greer, Jorden Schmidt, Amber D. Webb, Melissa K. Paine, Roert Callahan, Sean J. Waddoups, Lindsey J. Yamane, Misty B. Self, Wesley H. Rice, Todd W. Casey, Jonathan D. Johnson, Jakea Gray, Christopher Hays, Margaret Roth, Megan Menon, Vidya Kasubhai, Moiz Pillai, Anjana Daniel, Jean Sittler, Daniel Kanna, Balavenkatesh Jilani, Nargis Amaro, Francisco Santana, Jessica Lyakovestsky, Aleksandr Madhoun, Issa Desroches, Louis Marie Amadon, Nicole Bahr, Alaa Ezzat, Imaan Guerrero, Maryanne Padilla, Joane Fullmer, Jessie Singh, Inderpreet Ali Shah, Syed Hamad Narang, Rajeev Mock, Polly Shadle, Melissa Hernandez, Brenda Welch, Kevin Payne, Andrea Ertl, Gabriela Canario, Daniel Barrientos, Isabel Goss, Danielle DeVries, Mattie Folowosele, Ibidolapo Garner, Dorothy Gomez, Mariana Price, Justin Bansal, Ekta Wong, Jim Faulhaber, Jason Fazili, Tasaduq Yeary, Brian Ndolo, Ruth Bryant, Christina Smigeil, Bridgette Robinson, Philip Najjar, Rana Jones, Patrice Nguyen, Julie Chin, Christina Taha, Hassan Najm, Salah Smith, Christopher Moore, Jason Nassar, Talal Gallinger, Nick Christian, Amy Mauer, D'Amber Phipps, Ashley Waters, Michael Zepeda, Karla Coslet, Jordan Landazuri, Rosalynn Pineda, Jacob Uribe, Nicole Garcia, Jose Ruiz Barbabosa, Cecilia Sandler, Kaitlyn Overcash, J. Scott Marquez, Adrienna Chu, Hanh Lee, Kia Quillin, Kimberly Garcia, Andrea Lew, Pauline Rogers, Ralph Shehadeh, Fadi Mylona, Evangelia K. Kaczynski, Matthew Tran, Quynh-Lam Benitez, Gregorio Mishra, Biswajit Felix, Lewis Oscar Vafea, Maria Tsikala Atalla, Eleftheria Davies, Robin Hedili, Salma Monkeberg, Maria Andrea Tabler, Sandra Harrington, Britt Meegada, Sreenath Koripalli, Venkata Sandeep Muddana, Prithvi Jain, Lakshay Undavalli, Chaitanya Kavya, Parasa Ibiwoye, Mofoluwaso Akilo, Hameed Lovette, Bryce D. Wylie, Jamie-Crystal Smith, Diana M. Poon, Kenneth Eckardt, Paula Heysu, Rubio-Gomez Sundararaman, Nithya Alaby, Doris Sareli, Candice Sánchez, Adriana Popielski, Laura Kambo, Amy Viens, Kimberley Turner, Melissa Vjecha, Michael J. Brar, Indira Markowitz, Norman Pastor, Erika Corpuz, Roweena Alangaden, George McKinnon, John Ramesh, Mayur Herc, Erica Yared, Nicholas Lanfranco, Odaliz Abreu Rivers, Emanuel Swiderek, Jennifer Gupta, Ariella Hodari Pabla, Pardeep Eliya, Sonia Jazrawi, Jehan Delor, Jeremy Desai, Mona Cook, Aaron Jaehne, Anja Kathrina Gill, Jasreen Kaur Renaud, Sheri Sarveswaran, Siva Gardner, Edward Scott, James Bianchini, Monica Melvin, Casey Kim, Gina Wyles, David Kamis, Kevin Miller, Rachel Douglas, Ivor Haukoos, Jason Hicks, Carrie Lazarte, Susana Marines-Price, Rubria Osuji, Alice Agbor Agbor, Barbine Tchamba Petersen, Tianna Kamel, Dena Hansen, Laura Garcia, Angie Cha, Christine Mozaffari, Azadeh Hernandez, Rosa Cutrell, James Kim, Mina DellaValle, Natalie Gonzales, Sonia Somboonwit, Charurut Oxner, Asa Guerra, Lucy Hayes, Michael Nguyen, Thi Tran, Thanh Pinto, Avenette Hatlen, Timothy Anderson, Betty Zepeda-Gutierrez, Ana Martin, Dannae Temblador, Cindi Cuenca, Avon Tanoviceanu, Roxanne Prieto, Martha Guerrero, Mario Daar, Eric Correa, Ramiro Hartnell, Gabe Wortmann, Glenn Doshi, Saumil Moriarty, Theresa Gonzales, Melissa Garman, Kristin Frosch, Anne Goldsmith, Rachael Driver, Brian Frank, Christine Leviton, Tzivia Prekker, Matthew Jibrell, Hodan Lo, Melanie Klaphake, Jonathan Mackedanz, Shari Ngo, Linh Garcia-Myers, Kelly Kunisaki, Ken M. Wendt, Chris Melzer, Anne Wetherbee, Erin Drekonja, Dimitri Pragman, Alexa Hamel, Aimee Thielen, Abbie Hassler, Miranda Walquist, Mary Augenbraun, Michael George, Jensen Demeo, Lynette Mishko, Motria Thomas, Lorraine Tatem, Luis Dehovitz, Jack Leuck, Anne-Marie Rao, Via Pullen, Matthew Luke, Darlette LaBar, Derek Christiansen, Theresa Howard, Diondra Biswas, Kousick Harrington, Cristin Garcia, Amanda Bremer, Tammy Burke, Tara Koker, Brittany Davis-Karim, Anne Pittman, David Vasudeva, Shikha S. Johnstone, Jaylynn R. Agnetti, Kate Davis, Ruby Trautner, Barbara Hines-Munson, Casey Van, John Dillon, Laura Wang, Yiqun Ochalek, Tracy Caldwell, Erin Humerickhouse, Edward Boone, David McGraw, William Mehta, Sanjay R. Johns, Scott Thompson St. John, Melissa Raceles, Jacqueline Sear, Emily Funk, Stephen Cesarini, Rosa Fang, Michelle Nicalo, Keith Drake, Wonder Jones, Beatrice Holtman, Teresa Nguyen, Hien H. Maniar, Archana Johnson, Eric A. Nguyen, Lam Tran, Michelle T. Barrett, Thomas W. Johnston, Tera Huggins, John T. Beiko, Tatsiana Y. Hughes, Heather Y. McManigle, William C. Tanner, Nichole T. Washburn, Ronald G. Tuohy, Patricia A. Mixson, Jennifer L. Hinton, Charles G. Thornley, Nicola Allen, Heather Elam, Shannon Boatman, Barry Baber, Brittany J. Ryant, Rudell Roller, Brentin Nguyen, Chinh Mikail, Amani Morgan Research, Marivic Hansen Lichtenberger, Paola Baracco, Gio Ramos, Carol Bjork, Lauren Sueiro, Melyssa Tien, Phyllis Freasier, Heather Buck, Theresa Nekach, Hafida Chary, Aarthi Lu, Kan Peters, Theresa Lopez, Jessica Tan, Susanna Yu Lee, Robert H. Asghar, Aliya Karyn Isip, Tasadduq Karim Le, Katherine Nguyen, Thao Wong, Shinn Raben, Dorthe Peters, Lars Aagaard, Bitten Nielsen, Charlotte B. Krapp, Katharina Nykjær, Bente Rosdahl Olsson, Christina Kanne, Katja Lisa Grevsen, Anne Louise Joensen, Zillah Maria Bruun, Tina Bojesen, Ane Woldbye, Frederik Normand, Nick E. Esman, Frederik V.L. Benfield, Thomas Clausen, Clara Lundetoft Hovmand, Nichlas Israelsen, Simone Bastrup Iversen, Katrine Leding, Caecilie Pedersen, Karen Brorup Thorlacius-Ussing, Louise Tinggaard, Michaela Tingsgard, Sandra Krohn-Dehli, Louise Pedersen, Dorthe Villadsen, Signe Staehr Jensen, Jens-Ulrik Overgaard, Rikke Rastoder, Ema Heerfordt, Christian Hedsund, Caroline Ronn, Christian Phillip Kamstrup, Peter Thobias Hogsberg, Dorthe Sandbaek Bergsoe, Christina Søborg, Christian Hissabu, Nuria M.S. Arp, Bodil C. Ostergaard, Lars Staerke, Nina Breinholt Yehdego, Yordanos Sondergaard, Ane Johansen, Isik S. Pedersen, Andreas Arnholdt Knudtzen, Fredrikke C. Larsen, Lykke Hertz, Mathias A. Fabricius, Thilde Holden, Inge K. Lindvig, Susan O. Helleberg, Marie Gerstoft, Jan Kirk, Ole Madsen, Birgitte Lindegaard Pedersen, Thomas Ingemann Harboe, Zitta Barrella Roge, Birgit Thorup Hansen, Thomas Michael Glesner, Matilde Kanstrup Lofberg, Sandra Valborg Nielsen, Ariella Denize Leicht von Huth, Sebastian Nielsen, Henrik Thisted, Rikke Krog Petersen, Kristine Toft Juhl, Maria Ruwald Podlekareva, Daria Johnsen, Stine Andreassen, Helle Frost Pedersen, Lars Clara Ellinor Lindnér, Cecilia Ebba Wiese, Lothar Knudsen, Lene Surland Skrøder Nytofte, Nikolaj Julian Havmøller, Signe Ravn Expósito, Maria Badillo, José Martínez, Ana Abad, Elena Chamorro, Ana Figuerola, Ariadna Mateu, Lourdes España, Sergio Lucero, Maria Constanza Santos, José Ramón Lladós, Gemma Lopez, Cristina Carabias, Lydia Molina-Morant, Daniel Loste, Cora Bracke, Carmen Siles, Adrian Fernández-Cruz, Eduardo Di Natale, Marisa Padure, Sergiu Gomez, Jimena Ausin, Cristina Cervilla, Eva Balastegui, Héctor Sainz, Carmen Rodríguez Lopez, Paco Carbone, Javier Escobar, Mariam Balerdi, Leire Legarda, Almudena Roldan, Montserrat Letona, Laura Muñoz, José Camprubí, Daniel Arribas, Jose R. Sánchez, Rocio Montejano Díaz-Pollán, Beatriz Stewart, Stefan Mark Garcia, Irene Borobia, Alberto Mora-Rillo, Marta Estrada, Vicente Cabello, Noemi Nuñez-Orantos, M.J. Sagastagoitia, I. Homen, J.R. Orviz, E. Montalvá, Adrián Sánchez Espinosa-Pereiro, Juan Bosch-Nicolau, Pau Salvador, Fernando Burgos, Joaquin Morales-Rull, Jose Luis Moreno Pena, Anna Maria Acosta, Cristina Solé-Felip, Cristina Horcajada, Juan P. Sendra, Elena Castañeda, Silvia López-Montesinos, Inmaculada Gómez-Junyent, Joan Gonzáles, Carlota Gudiol Cuervo, Guilermo Pujol, Miquel Carratalà, Jordi Videla, Sebastià Günthard, Huldrych Braun, Dominique L. West, Emily M'Rabeth-Bensalah, Khadija Eichinger, Mareile L. Grüttner-Durmaz, Manuela Grube, Christina Zink, Veronika pharmacist Goes pharmacist, Josefine Fätkenheuer, Gerd Malin, Jakob J. Tsertsvadze, Tengiz Abutidze, Akaki Chkhartishvili, Nikoloz Metchurtchlishvili, Revaz Endeladze, Marina Paciorek, Marcin Bursa, Dominik Krogulec, Dominika Pulik, Piotr Ignatowska, Anna Horban, Andrzej Bakowska, Elzbieta Kowaska, Justyna Bednarska, Agnieszka Jurek, Natalia Skrzat-Klapaczynska, Agata Bienkowski, Carlo Hackiewicz, Malgorzata Makowiecki, Michal Platowski, Antoni Fishchuk, Roman Kobrynska, Olena Levandovska, Khrystyna Kirieieva, Ivanna Kuziuk, Mykhailo Naucler, Pontus Perlhamre, Emma Mazouch, Lotta Kelleher, Anthony Polizzotto, Mark Carey, Catherine Chang, Christina C. Hough, Sally Virachit, Sophie Davidson, Sarah Bice, Daniel J. Ognenovska, Katherine Cabrera, Gesalit Flynn, Ruth Young, Barnaby E. Chia, Po Ying Lee, Tau Hong Lin, Ray J. Lye, David C. Ong, Sean W.X. Puah, Ser Hon Yeo, Tsin Wen Diong, Shiau Hui Ongko, Juwinda Yeo, He Ping Eriobu, Nnakelu Kwaghe, Vivian Zaiyad, Habib Idoko, Godwin Uche, Blessing Selvamuthu, Poongulali Kumarasamy, Nagalingeswaran Beulah, Faith Ester Govindarajan, Narayan Mariyappan, Kowsalya Losso, Marcelo H. Abela, Cecilia Moretto, Renzo Belloc, Carlos G. Ludueña, Jael Amar, Josefina Toibaro, Javier Macias, Laura Moreno Fernandez, Lucia Frare, Pablo S. Chaio, Sebastian R. Pachioli, Valeria Timpano, Stella M. Sanchez, Marisa del Lujan de Paz Sierra, Mariana Stanek, Vanina Belloso, Waldo Cilenti, Flavia L. Valentini, Ricardo N. Stryjewski, Martin E. Locatelli, Nicolas Soler Riera, Maria C. Salgado, Clara Baeck, Ines M. Di Castelnuovo, Valentina Zarza, Stella M. Hudson, Fleur Parmar, Mahesh K.B. Dphil Badrock, Jonathan Gregory, Adam Goodall, Katharine Harris, Nicola Wyncoll, James Bhagani, S. Rodger, A. Luntiel, A. Patterson, C. Morales, J. Witele, E. Preston, A.-M. Nandani, A. Price, D.A. Hanrath, Aiden Nell, Jeremy Patel, Bijal Hays, Carole Jones, Geraldine Davidson, Jade Bawa, T. Mathews, M. Mazzella, A. Bisnauthsing, K. Aguilar-Jimenez, L. Borchini, F. Hammett, S. Touloumi, Giota Pantazis, Nikos Gioukari, Vicky Souliou, Tania Antoniadou, A. Protopapas, K. Kavatha, D. Grigoropoulou, S. Oikonomopoulo, C. Koulouris, N.G. Tzimopoulos, K. Koromilias, A. Argyraki, K. Lourida, P. Bakakos, P. Kalomenidis, I. Vlachakos, V. Barmparessou, Z. Balis, E. Zakynthinos, S. Sigala, I. Gianniou, N. Dima, E. Magkouta, S. Synolaki, E. Konstanta, S. Vlachou, M. Stathopoulou, P. Panagopoulos, P. Petrakis, V. Papazoglou, D. Tompaidou, E. Isaakidou, E. Poulakou, G. Rapti, V. Leontis, K. Nitsotolis, T. Athanasiou, K. Syrigos, K. Kyriakoulis, K. Trontzas, I. Arfara-Melanini, M. Kolonis, V. Kityo, Cissy Kiweewa, Francis Kimuli, Ivan Lukaakome, Joseph Nsereko, Christoher Lubega, Gloria Kibirige, Moses Nakahima, William Wangi, Deus Aguti, Evelyne Generous, Lilian Massa, Rosemary Nalaki, Margaret Magala, Felix Nabaggala, Phiona Kaweesi Kidega, Robert Faith, Oryem Daizy Florence, Apio Emmanuel, Ocung Beacham, Mugoonyi Paul Geoffrey, Amone Nakiboneka, Dridah Apiyo, Paska Kirenga, Bruce Atukunda, Angella Muttamba, Winters Remmy, Kyeyume Segawa, Ivan Pheona, Nsubuga Kigere, David Mbabazi, Queen Lailah Boersalino, Ledra Nyakoolo, Grace Fred, Aniongo Alupo, Alice Ebong, Doryn Monday, Edson Nalubwama, Ritah Norah Kainja, Milton Ambrose, Munu Kwehayo, Vanon Nalubega, Mary Grace Ongoli, Augustine Obbo, Stephen Sebudde, Nicholus Alaba, Jeniffer Magombe, Geoffrey Tino, Harriet Obonya, Emmanuel Lutaakome, Joseph Kitonsa, Jonathan Onyango, Martin Naboth, Tukamwesiga Naluyinda, Hadijah Nanyunja, Regina Irene, Muttiibwa Jane, Biira Wimfred, Kyobejja Leonard, Ssemazzi Deus, Tkiinomuhisha Babra, Namasaba Taire, Paul Nabankema, Evelyn Ogavu, Joseph Mugerwa, Oscar Okoth, Ivan Mwebaze, Raymond Mugabi, Timothy Makhoba, Anthony Arikiriza, Phiona Theresa, Nabuuma Nakayima, Hope Frank, Kisuule Ramgi, Patrícia Pereira, Kássia Osinusi, Anu Cao, Huyen Klekotka, Paul Price, Karen Nirula, Ajay Osei, Suzette Tipple, Craig Wills, Angela Peppercorn, Amanda Watson, Helen Gupta, Rajesh Alexander, Elizabeth Mogalian, Erik Lin, Leo Ding, Xiao Margolis, David Yan, Li Girardet, Jean-Luc Ma, Ji Hong, Zhi Zhu, Quing Seegobin, Seth Gibbs, Michael Latchman, Mickel Hasior, Katarzyna Bouquet, Jerome Wei, Jianxin Streicher, Katie Schmelzer, Albert Brooks, Dennis Butcher, Jonny Tonev, Dimitar Arbetter, Douglas Damstetter, Philippe Legenne, Philippe Stumpp, Michael Goncalves, Susana Ramanathan, Krishnan Chandra, Richa Baseler, Beth Teitelbaum, Marc Schechner, Adam Holley, H. Preston Jankelevich, Shirley Becker, Nancy Dolney, Suzanne Hissey, Debbie Simpson, Shelly Kim, Mi Ha Beeler, Joy Harmon, Liam Asomah, Mabel Jato, Yvonne Stottlemyer, April Tang, Olivia Vanderpuye, Sharon Yeon, Lindsey Buehn, Molly Eccard-Koons, Vanessa Frary, Sadie MacDonald, Leah Cash, Jennifer Hoopengardner, Lisa Linton, Jessica Schaffhauser, Marylu Nelson, Michaela Spinelli-Nadzam, Mary Proffitt, Calvin Lee, Christopher Engel, Theresa Fontaine, Laura Osborne, C.K. Hohn, Matt Galcik, Michael Thompson, DeeDee Kopka, Stacey Shelley, Denise M. Mendez, Gregg Brown, Shawn Albert, Sara Balde, Abby Baracz, Michelle Bielica, Mona Billouin-Frazier, Shere Choudary, Jay Dixon, Mary Eyler, Carolyn Frye, Leanne Gertz, Jensen Giebeig, Lisa Gulati, Neelam Hankinson, Liz Hogarty, Debi Huber, Lynda Krauss, Gary Lake, Eileen Manandhar, Meryan Rudzinski, Erin Sandrus, Jen Suders, Connie Natarajan, Ven Baseler, Michael Lynam, Danielle Imamichi, Tom McCormack, Ashley Paudel, Sharada Cook, Kyndal Haupt, Kendra Khan, Ayub Hazen, Allison Badralmaa, Yunden Smith, Kenneth Patel, Bhakti Kubernac, Amanda Kubernac, Robert Hoover, Marie L. Solomon, Courtney Rashid, Marium Murphy, Joseph Brown, Craig DuChateau, Nadine Ellis, Sadie Flosi, Adam Fox, Lisa Johnson, Les Nelson, Rich Stojanovic, Jelena Treagus, Amy Wenner, Christine Williams, Richard |
| Publisher Information: |
2024. |
| Publication Year: |
2024 |
| Description: |
Background: Serial measurement of virological and immunological biomarkers in patients admitted to hospital with COVID-19 can give valuable insight into the pathogenic roles of viral replication and immune dysregulation. We aimed to characterise biomarker trajectories and their associations with clinical outcomes. Methods: In this international, prospective cohort study, patients admitted to hospital with COVID-19 and enrolled in the Therapeutics for Inpatients with COVID-19 platform trial within the Accelerating COVID-19 Therapeutic Interventions and Vaccines programme between Aug 5, 2020 and Sept 30, 2021 were included. Participants were included from 108 sites in Denmark, Greece, Poland, Singapore, Spain, Switzerland, Uganda, the UK, and the USA, and randomised to placebo or one of four neutralising monoclonal antibodies: bamlanivimab (Aug 5 to Oct 13, 2020), sotrovimab (Dec 16, 2020, to March 1, 2021), amubarvimab-romlusevimab (Dec 16, 2020, to March 1, 2021), and tixagevimab-cilgavimab (Feb 10 to Sept 30, 2021). This trial included an analysis of 2149 participants with plasma nucleocapsid antigen, anti-nucleocapsid antibody, C-reactive protein (CRP), IL-6, and D-dimer measured at baseline and day 1, day 3, and day 5 of enrolment. Day-90 follow-up status was available for 1790 participants. Biomarker trajectories were evaluated for associations with baseline characteristics, a 7-day pulmonary ordinal outcome, 90-day mortality, and 90-day rate of sustained recovery. Findings: The study included 2149 participants. Participant median age was 57 years (IQR 46–68), 1246 (58·0%) of 2149 participants were male and 903 (42·0%) were female; 1792 (83·4%) had at least one comorbidity, and 1764 (82·1%) were unvaccinated. Mortality to day 90 was 172 (8·0%) of 2149 and 189 (8·8%) participants had sustained recovery. A pattern of less favourable trajectories of low anti-nucleocapsid antibody, high plasma nucleocapsid antigen, and high inflammatory markers over the first 5 days was observed for high-risk baseline clinical characteristics or factors related to SARS-CoV-2 infection. For example, participants with chronic kidney disease demonstrated plasma nucleocapsid antigen 424% higher (95% CI 319–559), CRP 174% higher (150–202), IL-6 173% higher (144–208), D-dimer 149% higher (134–165), and anti-nucleocapsid antibody 39% lower (60–18) to day 5 than those without chronic kidney disease. Participants in the highest quartile for plasma nucleocapsid antigen, CRP, and IL-6 at baseline and day 5 had worse clinical outcomes, including 90-day all-cause mortality (plasma nucleocapsid antigen hazard ratio (HR) 4·50 (95% CI 3·29–6·15), CRP HR 3·37 (2·30–4·94), and IL-6 HR 5·67 (4·12–7·80). This risk persisted for plasma nucleocapsid antigen and CRP after adjustment for baseline biomarker values and other baseline factors. Interpretation: Patients admitted to hospital with less favourable 5-day biomarker trajectories had worse prognosis, suggesting that persistent viral burden might drive inflammation in the pathogenesis of COVID-19, identifying patients that might benefit from escalation of antiviral or anti-inflammatory treatment. Funding: US National Institutes of Health. © 2024 The Author(s) |
| Document Type: |
Article |
| Language: |
English |
| Access URL: |
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3483811 |
| Accession Number: |
edsair.od......2127..af633a0c319afccd63281ab73a8fd30a |
| Database: |
OpenAIRE |
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