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Predicting solvation free energies for neutral molecules in any solvent with openCOSMO-RS

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Názov: Predicting solvation free energies for neutral molecules in any solvent with openCOSMO-RS
Autori: Müller, Simon, Nevolianis, Thomas, Riplinger, Christoph, Leonhard, Kai, Smirnova, Irina
Zdroj: Fluid phase equilibria. 589
Informácie o vydavateľovi: 2025.
Rok vydania: 2025
Predmety: Solvation free energies, Activity coefficients, Phase equilibrium, Partition coefficients, COSMO-RS, openCOSMO-RS
Popis: In this study, we introduce openCOSMO-RS 24a, an improved version of the open-source COSMO-RS model parameterized using quantum chemical calculations from ORCA 6.0, leveraging a comprehensive dataset that includes solvation free energies, partition coefficients, and infinite dilution activity coefficients for various solutes and solvents mainly at 25 °C. This is the first version of the model also capable of predicting solvation free energies based on ORCA calculations. Additionally, we develop a Quantitative Structure-Property Relationships model to predict molar volumes of the solvents, an essential requirement for predicting solvation free energies and partition coefficients from structure alone. Our results show that openCOSMO-RS 24a achieves an average absolute deviation of 0.45 kcal mol1 for solvation free energies, 0.76 for the logarithm of the partition coefficients, and 0.51 for the logarithm of infinite dilution activity coefficients, demonstrating improvements over the previous openCOSMO-RS 22 parameterization and comparable results to COSMOtherm 24 BP-TZVP. The user interface was extended to be able to use it as solvation model directly from within ORCA 6.0 or from the command line to provide researchers with a robust tool for applications in chemical and materials science.
Druh dokumentu: Article
Jazyk: English
ISSN: 0378-3812
DOI: 10.15480/882.13678
Rights: CC BY
Prístupové číslo: edsair.dris...01170..1782f86b7ec60134d207fc9900bc4196
Databáza: OpenAIRE
Popis
Abstrakt:In this study, we introduce openCOSMO-RS 24a, an improved version of the open-source COSMO-RS model parameterized using quantum chemical calculations from ORCA 6.0, leveraging a comprehensive dataset that includes solvation free energies, partition coefficients, and infinite dilution activity coefficients for various solutes and solvents mainly at 25 °C. This is the first version of the model also capable of predicting solvation free energies based on ORCA calculations. Additionally, we develop a Quantitative Structure-Property Relationships model to predict molar volumes of the solvents, an essential requirement for predicting solvation free energies and partition coefficients from structure alone. Our results show that openCOSMO-RS 24a achieves an average absolute deviation of 0.45 kcal mol1 for solvation free energies, 0.76 for the logarithm of the partition coefficients, and 0.51 for the logarithm of infinite dilution activity coefficients, demonstrating improvements over the previous openCOSMO-RS 22 parameterization and comparable results to COSMOtherm 24 BP-TZVP. The user interface was extended to be able to use it as solvation model directly from within ORCA 6.0 or from the command line to provide researchers with a robust tool for applications in chemical and materials science.
ISSN:03783812
DOI:10.15480/882.13678