Low Catalytic Redox Activity of α-N-Pyridylthiosemicarbazone Iron Complexes Suggests an Indirect ROS Generation Mechanism in Their Biological Activity
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| Název: | Low Catalytic Redox Activity of α-N-Pyridylthiosemicarbazone Iron Complexes Suggests an Indirect ROS Generation Mechanism in Their Biological Activity |
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| Autoři: | Vinjamuri, Bharath, Kowol, Christian R, Faller, Peter |
| Zdroj: | Inorganic Chemistry. 64(40):20340-20347 |
| Informace o vydavateli: | AMER CHEMICAL SOC, 2025. |
| Rok vydání: | 2025 |
| Témata: | 104004 Chemische Biologie, Molecular Structure, Iron/chemistry, Reactive Oxygen Species/metabolism, Thiosemicarbazones/chemistry, 104004 Chemical biology, Humans, Ascorbic Acid/chemistry, Coordination Complexes/chemistry, 104003 Anorganische Chemie, Oxidation-Reduction, Catalysis, 104003 Inorganic chemistry |
| Popis: | α-N-Pyridylthiosemicarbazones (PTSC) are anticancer agents that can induce oxidative stress in cells, likely through interactions with metal ions. Redox-active Cu and Fe bind strongly to PTSC, forming complexes Cu-PTSC and Fe-PTSC2. These complexes have been proposed to directly catalyze the formation of reactive oxygen species (ROS) and deplete key cellular reductants, thereby exerting oxidative stress. Alternatively, oxidative stress could also arise indirectly through interactions with other cellular targets. Evaluating catalytic rates could help distinguish direct from indirect mechanisms, as ROS production should outpace antioxidant defenses. In this respect, the catalytic activity of the Fe complexes of two PTSCs, Triapine (3AP) and Dp44mT, with the two most abundant reducing agents, ascorbate and glutathione, was evaluated under aerobic conditions. Fe-3AP2 and Fe-Dp44mT2 showed very low catalytic activity in depleting GSH/ascorbate and producing ROS ( |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/acs.inorgchem.5c03520 |
| Přístupová URL adresa: | https://ucrisportal.univie.ac.at/de/publications/5cc12454-44cd-4375-846e-b4476c95e948 |
| Přístupové číslo: | edsair.dris...00911..67623e416ef95c4c5b99d9f8771cc575 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | α-N-Pyridylthiosemicarbazones (PTSC) are anticancer agents that can induce oxidative stress in cells, likely through interactions with metal ions. Redox-active Cu and Fe bind strongly to PTSC, forming complexes Cu-PTSC and Fe-PTSC2. These complexes have been proposed to directly catalyze the formation of reactive oxygen species (ROS) and deplete key cellular reductants, thereby exerting oxidative stress. Alternatively, oxidative stress could also arise indirectly through interactions with other cellular targets. Evaluating catalytic rates could help distinguish direct from indirect mechanisms, as ROS production should outpace antioxidant defenses. In this respect, the catalytic activity of the Fe complexes of two PTSCs, Triapine (3AP) and Dp44mT, with the two most abundant reducing agents, ascorbate and glutathione, was evaluated under aerobic conditions. Fe-3AP2 and Fe-Dp44mT2 showed very low catalytic activity in depleting GSH/ascorbate and producing ROS ( |
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| ISSN: | 1520510X 00201669 |
| DOI: | 10.1021/acs.inorgchem.5c03520 |