Vitamin D Concentrations in Infancy and the Risk of Tuberculosis Disease in Childhood: A Prospective Birth Cohort in Cape Town, South Africa
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| Název: | Vitamin D Concentrations in Infancy and the Risk of Tuberculosis Disease in Childhood: A Prospective Birth Cohort in Cape Town, South Africa |
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| Autoři: | Maresa Botha, Lesley Workman, Liz Goddard, Mark P. Nicol, Jabulani Ncayiyana, Leonardo Martinez, Landon Myer, Tiffany Burd, Heather J. Zar |
| Zdroj: | Clin Infect Dis |
| Informace o vydavateli: | Oxford University Press (OUP), 2021. |
| Rok vydání: | 2021 |
| Témata: | Infant, Newborn, Infant, HIV Infections, Tuberculin, Vitamin D Deficiency, 3. Good health, Major Articles and Commentaries, South Africa, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Child, Preschool, Humans, Tuberculosis, Birth Cohort, Female, Prospective Studies, Vitamin D, Child |
| Popis: | Background Low vitamin D levels may increase the risk of tuberculosis disease; however, previous observational cohort studies showed variable results. We investigated the relationship between vitamin D levels in infancy and subsequent development of tuberculosis disease throughout childhood. Methods We enrolled pregnant women at 20–28 weeks’ gestation attending antenatal care in a periurban South African setting in the Drakenstein Child Health Study. Serum 25(OH)D concentrations were measured in newborn infants aged 6–10 weeks. Children were followed prospectively for tuberculosis infection and disease using annual tuberculin skin testing, radiographic examinations, and microbiological diagnosis with GeneXpert, culture, and smear testing. Univariable and multivariable Cox regression was performed and HRs with 95% CIs were calculated. Results Children were followed for tuberculosis disease for a median of 7.2 years (IQR, 6.2–7.9). Among 744 children ( Conclusions In a setting with hyperendemic rates of tuberculosis, vitamin D concentrations in infancy did not predict tuberculosis disease at any point in childhood. However, very low vitamin D levels were associated with tuberculin conversion in young children. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/ciab735 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/34436538 https://research-repository.uwa.edu.au/en/publications/vitamin-d-concentrations-in-infancy-and-the-risk-of-tuberculosis- https://www.ncbi.nlm.nih.gov/pubmed/34436538 |
| Rights: | CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....fede2c36c8327ba60044edbeb035a508 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Background Low vitamin D levels may increase the risk of tuberculosis disease; however, previous observational cohort studies showed variable results. We investigated the relationship between vitamin D levels in infancy and subsequent development of tuberculosis disease throughout childhood. Methods We enrolled pregnant women at 20–28 weeks’ gestation attending antenatal care in a periurban South African setting in the Drakenstein Child Health Study. Serum 25(OH)D concentrations were measured in newborn infants aged 6–10 weeks. Children were followed prospectively for tuberculosis infection and disease using annual tuberculin skin testing, radiographic examinations, and microbiological diagnosis with GeneXpert, culture, and smear testing. Univariable and multivariable Cox regression was performed and HRs with 95% CIs were calculated. Results Children were followed for tuberculosis disease for a median of 7.2 years (IQR, 6.2–7.9). Among 744 children ( Conclusions In a setting with hyperendemic rates of tuberculosis, vitamin D concentrations in infancy did not predict tuberculosis disease at any point in childhood. However, very low vitamin D levels were associated with tuberculin conversion in young children. |
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| ISSN: | 15376591 10584838 |
| DOI: | 10.1093/cid/ciab735 |