Optical coherence tomography in multiple sclerosis: A 3‐year prospective multicenter study: A 3-year prospective multicenter study
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| Názov: | Optical coherence tomography in multiple sclerosis: A 3‐year prospective multicenter study: A 3-year prospective multicenter study |
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| Autori: | Ursula Schmidt-Erfurth, Shiv Saidha, Patrick Vermersch, Sven Schippling, Bianca S Gerendas, Friedemann Paul, Gustavo Seifer, Ari J. Green, Axel Petzold, Peter A. Calabresi, Jaume Sastre-Garriga, Frederik Barkhof, Catherine Agoropoulou, Ying Zhang, Randy H. Kardon |
| Prispievatelia: | Institut Català de la Salut, [Paul F] NeuroCure Clinical Research Center and Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin, Germany. [Calabresi PA] Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland. [Barkhof F] Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands. Institutes of Neurology & Centre for Medical Image Computing, University College London, London, UK. [Green AJ] Department of Neurology, Multiple Sclerosis Center, University of California San Francisco, San Francisco, Califonia. [Kardon R] Iowa City VA Center for Prevention and Treatment of Visual Loss, Department of Veterans Affairs Hospital Iowa City, University of Iowa Hospital and Clinics, Iowa City, Iowa. Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, Iowa. [Sastre-Garriga J] Servei de Neurologia-Neuroimmunologia, Esclerosi Múltiple de Catalunya (CEMCAT), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Zdroj: | Ann Clin Transl Neurol Scientia Scientia. Dipòsit d'Informació Digital del Departament de Salut instname Annals of Clinical and Translational Neurology, Vol 8, Iss 12, Pp 2235-2251 (2021) Paul, F, Calabresi, P A, Barkhof, F, Green, A J, Kardon, R, Sastre-Garriga, J, Schippling, S, Vermersch, P, Saidha, S, Gerendas, B S, Schmidt-Erfurth, U, Agoropoulou, C, Zhang, Y, Seifer, G & Petzold, A 2021, 'Optical coherence tomography in multiple sclerosis : A 3-year prospective multicenter study', Annals of Clinical and Translational Neurology, vol. 8, no. 12, pp. 2235-2251. https://doi.org/10.1002/acn3.51473 Annals of Clinical and Translational Neurology, vol 8, iss 12 |
| Informácie o vydavateľovi: | Wiley, 2021. |
| Rok vydania: | 2021 |
| Predmety: | Male, Ulls - Tomografia, Esclerosi múltiple, Neurodegenerative, Relapsing-Remitting, Eye, 0302 clinical medicine, ANATOMÍA::órganos de los sentidos::ojo::retina, Prospective Studies, 10. No inequality, Tomography, Research Articles, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::imágenes ópticas::tomografía óptica::tomografía de coherencia óptica, screening and diagnosis, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Optical Imaging::Tomography, Optical::Tomography, Optical Coherence, Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen, Trastorns de la visió - Imatgeria, Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging, Brain, Middle Aged, 3. Good health, Detection, Neurological, Biomedical Imaging, Integrative Biomedicine [Topic 3], Female, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple::esclerosis múltiple recurrente-remitente, Function and Dysfunction of the Nervous System, Tomography, Optical Coherence, 4.2 Evaluation of markers and technologies, RC321-571, Adult, Multiple Sclerosis, Clinical Sciences, Neurosciences. Biological psychiatry. Neuropsychiatry, Autoimmune Disease, Retina, 03 medical and health sciences, Multiple Sclerosis, Relapsing-Remitting, Clinical Research, Humans, ANATOMY::Sense Organs::Eye::Retina, RC346-429, Eye Disease and Disorders of Vision, DISEASES::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis::Multiple Sclerosis, Relapsing-Remitting, Neurosciences, Brain Disorders, Optical Coherence, Neurology. Diseases of the nervous system, Atrophy |
| Popis: | ObjectiveTo evaluate changes over 3 years in the thickness of inner retinal layers including the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (mGCIPL), in individuals with relapsing‐remitting multiple sclerosis (RRMS) versus healthy controls; to determine whether optical coherence tomography (OCT) is sufficiently sensitive and reproducible to detect small degrees of neuroaxonal loss over time that correlate with changes in brain volume and disability progression as measured by the Expanded Disability Status Scale (EDSS).MethodsIndividuals with RRMS from 28 centers (n = 333) were matched with 64 healthy participants. OCT scans were performed on Heidelberg Spectralis machines (at baseline; 1 month; 6 months; 6‐monthly thereafter).ResultsOCT measurements were highly reproducible between baseline and 1 month (intraclass correlation coefficient >0.98). Significant inner retinal layer thinning was observed in individuals with multiple sclerosis (MS) compared with controls regardless of previous MS‐associated optic neuritis––group differences (95% CI) over 3 years: pRNFL: −1.86 (−2.54, −1.17) µm; mGCIPL: −2.03 (−2.78, −1.28) µm (both p 5 years (pRNFL: p p p InterpretationOCT has potential to estimate rates of neurodegeneration in the retina and brain. The effect size for OCT, smaller than for magnetic resonance imaging based on Heidelberg Spectralis data acquired in this study, was increased in early disease. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 2328-9503 |
| DOI: | 10.1002/acn3.51473 |
| Prístupová URL adresa: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/acn3.51473 https://pubmed.ncbi.nlm.nih.gov/34792863 https://hdl.handle.net/11351/7726 https://doaj.org/article/6cc487a878c54b178e7350a7d1571272 https://discovery.ucl.ac.uk/id/eprint/10138873/ https://research.vumc.nl/en/publications/optical-coherence-tomography-in-multiple-sclerosis-a-3-year-prosp https://www.ncbi.nlm.nih.gov/pubmed/34792863 http://edoc.mdc-berlin.de/21092/1/21092oa.pdf https://research.vumc.nl/en/publications/da2266e7-1805-439f-97dc-caf0d6c4be76 https://pure.amsterdamumc.nl/en/publications/2aa6f24a-e3a1-4983-b8eb-208718d26062 https://doi.org/10.1002/acn3.51473 https://discovery-pp.ucl.ac.uk/id/eprint/10138873/ https://escholarship.org/uc/item/5mv0p6xs https://escholarship.org/content/qt5mv0p6xs/qt5mv0p6xs.pdf |
| Rights: | CC BY NC ND URL: http://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
| Prístupové číslo: | edsair.doi.dedup.....fe8717e52b24a06c2e5d4a76ff173be7 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | ObjectiveTo evaluate changes over 3 years in the thickness of inner retinal layers including the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (mGCIPL), in individuals with relapsing‐remitting multiple sclerosis (RRMS) versus healthy controls; to determine whether optical coherence tomography (OCT) is sufficiently sensitive and reproducible to detect small degrees of neuroaxonal loss over time that correlate with changes in brain volume and disability progression as measured by the Expanded Disability Status Scale (EDSS).MethodsIndividuals with RRMS from 28 centers (n = 333) were matched with 64 healthy participants. OCT scans were performed on Heidelberg Spectralis machines (at baseline; 1 month; 6 months; 6‐monthly thereafter).ResultsOCT measurements were highly reproducible between baseline and 1 month (intraclass correlation coefficient >0.98). Significant inner retinal layer thinning was observed in individuals with multiple sclerosis (MS) compared with controls regardless of previous MS‐associated optic neuritis––group differences (95% CI) over 3 years: pRNFL: −1.86 (−2.54, −1.17) µm; mGCIPL: −2.03 (−2.78, −1.28) µm (both p 5 years (pRNFL: p p p InterpretationOCT has potential to estimate rates of neurodegeneration in the retina and brain. The effect size for OCT, smaller than for magnetic resonance imaging based on Heidelberg Spectralis data acquired in this study, was increased in early disease. |
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| ISSN: | 23289503 |
| DOI: | 10.1002/acn3.51473 |