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Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative

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Název: Effect of weight loss on knee joint synovitis over 48 months and mediation by subcutaneous fat around the knee: data from the Osteoarthritis Initiative
Autoři: Maximilian T. Löffler, Chotigar Ngarmsrikam, Paula Giesler, Gabby B. Joseph, Zehra Akkaya, John A. Lynch, Nancy E. Lane, Michael Nevitt, Charles E. McCulloch, Thomas M. Link
Zdroj: BMC Musculoskelet Disord
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-11 (2024)
BMC Musculoskeletal Disorders, vol 25, iss 1
Informace o vydavateli: Springer Science and Business Media LLC, 2024.
Rok vydání: 2024
Témata: Aging, Weight loss, Knee Joint, Clinical Sciences, Subcutaneous Fat, Clinical sciences, Diseases of the musculoskeletal system, Hoffa's fat pad, Female [MeSH], Aged [MeSH], Knee Joint/diagnostic imaging [MeSH], Osteoarthritis, Knee/complications [MeSH], Humans [MeSH], Inflammation [MeSH], Weight Loss [MeSH], Mediation analysis, Obesity/diagnostic imaging [MeSH], Synovitis/diagnostic imaging [MeSH], Obesity/complications [MeSH], Synovitis, Effusion, Osteoarthritis, Knee/diagnostic imaging [MeSH], Overweight/complications [MeSH], Subcutaneous Fat/diagnostic imaging [MeSH], Research, Osteoarthritis, Magnetic Resonance Imaging/methods [MeSH], 03 medical and health sciences, 0302 clinical medicine, Clinical Research, Health Sciences, Weight Loss, Humans, Knee, Obesity, Metabolic and endocrine, Nutrition, Cancer, Aged, Inflammation, 2. Zero hunger, Allied health and rehabilitation science, Biomedical and Clinical Sciences, Arthritis, Osteoarthritis, Knee, Overweight, Magnetic Resonance Imaging, ddc, 3. Good health, Orthopedics, RC925-935, Biomedical Imaging, Female, Sports science and exercise
Popis: Background Obesity influences the development of osteoarthritis via low-grade inflammation. Progression of local inflammation (= synovitis) increased with weight gain in overweight and obese women compared to stable weight. Synovitis could be associated with subcutaneous fat (SCF) around the knee. Purpose of the study was to investigate the effect of weight loss on synovitis progression and to assess whether SCF around the knee mediates the relationship between weight loss and synovitis progression. Methods We included 234 overweight and obese participants (body mass index [BMI] ≥ 25 kg/m2) from the Osteoarthritis Initiative (OAI) with > 10% weight loss (n = 117) or stable overweight (n = 117) over 48 months matched for age and sex. In magnetic resonance imaging (MRI) at baseline and 48 months, effusion-synovitis and Hoffa-synovitis using the MRI Osteoarthritis Knee Score (MOAKS) and average joint-adjacent SCF (ajSCF) were assessed. Odds-ratios (ORs) for synovitis progression over 48 months (≥ 1 score increase) were calculated in logistic regression models adjusting for age, sex, baseline BMI, Physical Activity Scale for the Elderly (PASE), and baseline SCF measurements. Mediation of the effect of weight loss on synovitis progression by local SCF change was assessed. Results Odds for effusion-synovitis progression decreased with weight loss and ajSCF decrease (odds ratio [OR] = 0.61 and 0.56 per standard deviation [SD] change, 95% confidence interval [CI] 0.44, 0.83 and 0.40, 0.79, p = 0.002 and 0.001, respectively), whereas odds for Hoffa-synovitis progression increased with weight loss and ajSCF decrease (OR = 1.47 and 1.48, CI 1.05, 2.04 and 1.02, 2.13, p = 0.024 and 0.038, respectively). AjSCF decrease mediated 39% of the effect of weight loss on effusion-synovitis progression. Conclusions Effusion-synovitis progression was slowed by weight loss and decrease in local subcutaneous fat. Hoffa-synovitis characterized by fluid in the infrapatellar fat pad increased at the same time, suggesting a decreasing fat pad rather than active synovitis. Decrease in local subcutaneous fat partially mediated the systemic effect of weight loss on synovitis.
Druh dokumentu: Article
Other literature type
Popis souboru: application/pdf; pdf
Jazyk: English
ISSN: 1471-2474
DOI: 10.1186/s12891-024-07397-y
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38627635
https://doaj.org/article/128d7f85bef643e2babcec9a4adfb6b9
https://repository.publisso.de/resource/frl:6500045
https://escholarship.org/content/qt8k8262kq/qt8k8262kq.pdf
https://escholarship.org/uc/item/8k8262kq
https://mediatum.ub.tum.de/1770492
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Přístupové číslo: edsair.doi.dedup.....fc973d8d747b172ce59dbbdd997eb656
Databáze: OpenAIRE
Popis
Abstrakt:Background Obesity influences the development of osteoarthritis via low-grade inflammation. Progression of local inflammation (= synovitis) increased with weight gain in overweight and obese women compared to stable weight. Synovitis could be associated with subcutaneous fat (SCF) around the knee. Purpose of the study was to investigate the effect of weight loss on synovitis progression and to assess whether SCF around the knee mediates the relationship between weight loss and synovitis progression. Methods We included 234 overweight and obese participants (body mass index [BMI] ≥ 25 kg/m2) from the Osteoarthritis Initiative (OAI) with > 10% weight loss (n = 117) or stable overweight (n = 117) over 48 months matched for age and sex. In magnetic resonance imaging (MRI) at baseline and 48 months, effusion-synovitis and Hoffa-synovitis using the MRI Osteoarthritis Knee Score (MOAKS) and average joint-adjacent SCF (ajSCF) were assessed. Odds-ratios (ORs) for synovitis progression over 48 months (≥ 1 score increase) were calculated in logistic regression models adjusting for age, sex, baseline BMI, Physical Activity Scale for the Elderly (PASE), and baseline SCF measurements. Mediation of the effect of weight loss on synovitis progression by local SCF change was assessed. Results Odds for effusion-synovitis progression decreased with weight loss and ajSCF decrease (odds ratio [OR] = 0.61 and 0.56 per standard deviation [SD] change, 95% confidence interval [CI] 0.44, 0.83 and 0.40, 0.79, p = 0.002 and 0.001, respectively), whereas odds for Hoffa-synovitis progression increased with weight loss and ajSCF decrease (OR = 1.47 and 1.48, CI 1.05, 2.04 and 1.02, 2.13, p = 0.024 and 0.038, respectively). AjSCF decrease mediated 39% of the effect of weight loss on effusion-synovitis progression. Conclusions Effusion-synovitis progression was slowed by weight loss and decrease in local subcutaneous fat. Hoffa-synovitis characterized by fluid in the infrapatellar fat pad increased at the same time, suggesting a decreasing fat pad rather than active synovitis. Decrease in local subcutaneous fat partially mediated the systemic effect of weight loss on synovitis.
ISSN:14712474
DOI:10.1186/s12891-024-07397-y