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Cardiac vagal activity changes moderated the association of cognitive and cerebral hemodynamic variations in the prefrontal cortex

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Title: Cardiac vagal activity changes moderated the association of cognitive and cerebral hemodynamic variations in the prefrontal cortex
Authors: Luqing Wei, Yuchun Chen, Xiuwen Chen, Chris Baeken, Guo-Rong Wu
Contributors: Neuroprotection & Neuromodulation, Clinical sciences, Brain, Body and Cognition, Psychiatry
Source: NeuroImage, Vol 297, Iss, Pp 120725-(2024)
Publisher Information: Elsevier BV, 2024.
Publication Year: 2024
Subject Terms: Male, Adult, Spectroscopy, Near-Infrared/methods, Adolescent, Functional Neuroimaging/methods, Cerebrovascular Circulation/physiology, Prefrontal Cortex, Neurosciences. Biological psychiatry. Neuropsychiatry, Hemodynamics/physiology, Executive function demands, Electrocardiography, Young Adult, Executive Function, 03 medical and health sciences, Cognition, 0302 clinical medicine, Memory, Heart Rate, Near-Infrared, Humans, Executive Function/physiology, 0501 psychology and cognitive sciences, Short-Term/physiology, Spectroscopy, Cognition/physiology, prefrontal cortex, Spectroscopy, Near-Infrared, Memory, Short-Term/physiology, 05 social sciences, Hemodynamics, Vagus Nerve, Neurovascular Coupling/physiology, Heart/innervation, Adaptation, Physiological, Healthy Volunteers, Memory, Short-Term, Prefrontal Cortex/physiology, Prefrontal Cortex/blood supply, Cerebrovascular Circulation, functional Near-Infrared Spectroscopy (fNIRS), young adult, Female, Vagus Nerve/physiology, Cardiac vagal activity, Heart Rate/physiology, RC321-571
Description: Phasic cardiac vagal activity (CVA), reflecting ongoing, moment-to-moment psychophysiological adaptations to environmental changes, can serve as a predictor of individual difference in executive function, particularly executive performance. However, the relationship between phasic CVA and executive function demands requires further validation because of previous inconsistent findings. Moreover, it remains unclear what types of phasic changes of CVA may be adaptive in response to heightened executive demands. This study used the standard N-back task to induce different levels of working memory (WM) load and combined functional Near-Infrared Spectroscopy (fNIRS) with a multipurpose polygraph to investigate the variations of CVA and its interactions with cognitive and prefrontal responses as executive demands increased in fifty-two healthy young subjects. Our results showed phasic decreases in CVA as WM load increased (t (51) = -3.758, p < 0.001, Cohen's d = 0.526). Furthermore, phasic changes of CVA elicited by increased executive demands moderated the association of cognitive and cerebral hemodynamic variations in the prefrontal cortex (B = 0.038, SE = 0.014, p < 0.05). Specifically, as executive demands increased, individuals with larger phasic CVA withdrawal showed a positive relationship between cognitive and hemodynamic variations in the prefrontal cortex (β = 0.281, p = 0.031). No such significant relationship was observed in individuals with smaller phasic CVA withdrawal. The current findings demonstrate a decrease in CVA with increasing executive demands and provide empirical support for the notion that a larger phasic CVA withdrawal can be considered adaptive in situations requiring high executive function demands.
Document Type: Article
Language: English
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2024.120725
Access URL: https://pubmed.ncbi.nlm.nih.gov/38977040
https://doaj.org/article/017cdff319ca4eefa5b6264ce4de3bbf
https://research.tue.nl/en/publications/b33fdd5d-7e1a-48f8-85c0-99c458ed27bb
https://doi.org/10.1016/j.neuroimage.2024.120725
https://biblio.vub.ac.be/vubir/cardiac-vagal-activity-changes-moderated-the-association-of-cognitive-and-cerebral-hemodynamic-variations-in-the-prefrontal-cortex(2200b031-8bde-463e-a508-8f9bdbc00a98).html
Rights: CC BY NC
Accession Number: edsair.doi.dedup.....fb3d6f959156008a1eb6813b2f8c7862
Database: OpenAIRE
Description
Abstract:Phasic cardiac vagal activity (CVA), reflecting ongoing, moment-to-moment psychophysiological adaptations to environmental changes, can serve as a predictor of individual difference in executive function, particularly executive performance. However, the relationship between phasic CVA and executive function demands requires further validation because of previous inconsistent findings. Moreover, it remains unclear what types of phasic changes of CVA may be adaptive in response to heightened executive demands. This study used the standard N-back task to induce different levels of working memory (WM) load and combined functional Near-Infrared Spectroscopy (fNIRS) with a multipurpose polygraph to investigate the variations of CVA and its interactions with cognitive and prefrontal responses as executive demands increased in fifty-two healthy young subjects. Our results showed phasic decreases in CVA as WM load increased (t (51) = -3.758, p < 0.001, Cohen's d = 0.526). Furthermore, phasic changes of CVA elicited by increased executive demands moderated the association of cognitive and cerebral hemodynamic variations in the prefrontal cortex (B = 0.038, SE = 0.014, p < 0.05). Specifically, as executive demands increased, individuals with larger phasic CVA withdrawal showed a positive relationship between cognitive and hemodynamic variations in the prefrontal cortex (β = 0.281, p = 0.031). No such significant relationship was observed in individuals with smaller phasic CVA withdrawal. The current findings demonstrate a decrease in CVA with increasing executive demands and provide empirical support for the notion that a larger phasic CVA withdrawal can be considered adaptive in situations requiring high executive function demands.
ISSN:10538119
DOI:10.1016/j.neuroimage.2024.120725