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Particulate matter at third trimester and respiratory infection in infants, modified by GSTM1

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Název: Particulate matter at third trimester and respiratory infection in infants, modified by GSTM1
Autoři: Song‐I Yang, Hyo‐Bin Kim, Hwan‐Cheol Kim, So‐Yeon Lee, Mi‐Jin Kang, Hyun‐Ju Cho, Jisun Yoon, Sungsu Jung, Eun Lee, Hyeon‐Jong Yang, Kangmo Ahn, Kyung Won Kim, Youn Ho Shin, Dong In Suh, Soo‐Jong Hong
Přispěvatelé: Song-I Yang, Hyo-Bin Kim, Hwan-Cheol Kim, So-Yeon Lee, Mi-Jin Kang, Hyun-Ju Cho, Jisun Yoon, Sungsu Jung, Eun Lee, Hyeon-Jong Yang, Kangmo Ahn, Kyung Won Kim, Youn Ho Shin, Dong In Suh, Soo-Jong Hong, Kim, Kyung Won
Zdroj: Pediatric Pulmonology. 55:245-253
Informace o vydavateli: Wiley, 2019.
Rok vydání: 2019
Témata: Adult, Male, prenatal, Pregnancy Trimester, Third, Nitrogen Dioxide, Air Pollutants / analysis, respiratory tract infections, Glutathione Transferase / genetics, Respiratory Tract Infections / genetics, 03 medical and health sciences, Ozone, 0302 clinical medicine, Genetic, Pregnancy, Nitrogen Dioxide / analysis, Third, 11. Sustainability, Humans, Polymorphism, Respiratory Tract Infections, Glutathione Transferase, particulate matter, third trimester, Air Pollutants, Polymorphism, Genetic, Prenatal Exposure Delayed Effects / epidemiology, Respiratory Tract Infections / epidemiology, Infant, Particulate Matter / analysis, Prenatal Exposure Delayed Effects / genetics, 3. Good health, Maternal Exposure, Prenatal Exposure Delayed Effects, Female, Particulate Matter, Pregnancy Trimester, Ozone / analysis, GSTM1
Popis: ObjectivesTo investigate the association between particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) exposure during each trimester of pregnancy and development of lower respiratory tract infections (LRTIs) during the first 3 years of life and whether GSTM1 gene polymorphisms modify these effects.MethodsThis study included 1,180 mother‐child pairs from the Cohort for Childhood Origin of Asthma and allergic diseases. The PM2.5 levels during pregnancy were estimated by residential address using land‐use regression models based on a national monitoring system. A diagnosis of LRTIs was based on a parental report of a physician's diagnosis. Real‐time polymerase chain reaction was used for GSTM1 genotyping.ResultsHigher PM2.5 exposure during the third trimester was associated with LRTIs at 1 year of age (aRR, 1.06; 95% CI, 1.00‐1.13). This result did not change after adjusting for PM2.5 exposures during the first and second trimesters (aRR, 1.06; 95% CI, 0.99‐1.13). This association was significant after adjusting for PM2.5 exposures during first year of age (aRR, 1.08; 95% CI, 1.02‐1.15) and exposures to NO2 and ozone at the third trimester (aRR, 1.07; 95% CI, 1.00‐1.16). In addition, PM2.5 exposure during the third trimester increased the risk of LRTIs at 1 year of age in cases with the GSTM1 null genotype (aRR, 1.26; 95% CI, 1.01‐1.57; P for interaction .20).ConclusionHigher PM2.5 exposure during the third trimester of pregnancy may increase the susceptibility to LRTIs at 1 year of age. This effect is modified by GSTM1 gene polymorphisms.
Druh dokumentu: Article
Jazyk: English
ISSN: 1099-0496
8755-6863
DOI: 10.1002/ppul.24575
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/31746563
https://www.ncbi.nlm.nih.gov/pubmed/31746563
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180589
http://www.ncbi.nlm.nih.gov/pubmed/31746563
https://pubmed.ncbi.nlm.nih.gov/31746563/
https://onlinelibrary.wiley.com/doi/abs/10.1002/ppul.24575
https://snucm.elsevierpure.com/en/publications/particulate-matter-at-third-trimester-and-respiratory-infection-i
Rights: Wiley Online Library User Agreement
CC BY NC ND
Přístupové číslo: edsair.doi.dedup.....fad7f952b1cc8d27c5514aa252a8759c
Databáze: OpenAIRE
Popis
Abstrakt:ObjectivesTo investigate the association between particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) exposure during each trimester of pregnancy and development of lower respiratory tract infections (LRTIs) during the first 3 years of life and whether GSTM1 gene polymorphisms modify these effects.MethodsThis study included 1,180 mother‐child pairs from the Cohort for Childhood Origin of Asthma and allergic diseases. The PM2.5 levels during pregnancy were estimated by residential address using land‐use regression models based on a national monitoring system. A diagnosis of LRTIs was based on a parental report of a physician's diagnosis. Real‐time polymerase chain reaction was used for GSTM1 genotyping.ResultsHigher PM2.5 exposure during the third trimester was associated with LRTIs at 1 year of age (aRR, 1.06; 95% CI, 1.00‐1.13). This result did not change after adjusting for PM2.5 exposures during the first and second trimesters (aRR, 1.06; 95% CI, 0.99‐1.13). This association was significant after adjusting for PM2.5 exposures during first year of age (aRR, 1.08; 95% CI, 1.02‐1.15) and exposures to NO2 and ozone at the third trimester (aRR, 1.07; 95% CI, 1.00‐1.16). In addition, PM2.5 exposure during the third trimester increased the risk of LRTIs at 1 year of age in cases with the GSTM1 null genotype (aRR, 1.26; 95% CI, 1.01‐1.57; P for interaction .20).ConclusionHigher PM2.5 exposure during the third trimester of pregnancy may increase the susceptibility to LRTIs at 1 year of age. This effect is modified by GSTM1 gene polymorphisms.
ISSN:10990496
87556863
DOI:10.1002/ppul.24575