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What would be the outcome if the American Diabetes Association recommendations of 2010 had been followed in our pratice in 1998–2006?

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Název: What would be the outcome if the American Diabetes Association recommendations of 2010 had been followed in our pratice in 1998–2006?
Autoři: N. Charnaux, Emmanuel Cosson, S. Chiheb, Paul Valensi, E. Hamo-Tchatchouang, Minh Tuan Nguyen, I. Banu
Přispěvatelé: ProdInra, Migration, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers CNAM (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Nord (Paris 13), IMAGE Ctr, Partenaires INRAE, Université Paris Cité (UPCité), Merck Lipha santeRegistered Trademark, Lyon, France
Zdroj: Diabetic Medicine. 28:567-574
Informace o vydavateli: Wiley, 2011.
Rok vydání: 2011
Témata: Adult, Blood Glucose, Male, [SDV]Life Sciences [q-bio], INTOLERANCE, oral glucose tolerance test, DIAGNOSIS, CLASSIFICATION, 03 medical and health sciences, 0302 clinical medicine, Outcome Assessment, Health Care, Humans, Mass Screening, HbA(1c), RISK, Glycated Hemoglobin, INSULIN-RESISTANCE, HEMOGLOBIN A1C, diabetes, STANDARDIZATION, Glucose Tolerance Test, Overweight, 3. Good health, [SDV] Life Sciences [q-bio], Diabetes Mellitus, Type 2, Practice Guidelines as Topic, intermediate hyperglycaemia, American Diabetes Association, Female, GLUCOSE-TOLERANCE, EXPERT COMMITTEE, RESISTANCE SYNDROME DESIR
Popis: Diabet. Med. 28, 567–574 (2011)AbstractAims In 2010, the American Diabetes Association has published recommendations on the population to be screened for dysglycaemia; the diagnostic criteria for intermediate hyperglycaemia and diabetes using oral glucose tolerance testing and HbA1c; and the patients eligible for treatment with metformin. We aimed to evaluate the consequences of screening with oral glucose tolerance test or HbA1c in an at‐risk population.Methods Among 1177 overweight or obese consecutive adults without known diabetes who were referred to our department for weight management, we selected 1157 individuals (83% female; 80% European) fulfilling the American Diabetes Association 2010 criteria for dysglycaemia screening.Results Mean age was 41.2 ± 13 years, BMI 37.0 ± 7.2 kg/m2, fasting plasma glucose 4.9 ± 0.8 mmol/l and HbA1c (turbidimetric immunoassay) 5.7 ± 0.7% (39 mmol/mol). Based on oral glucose tolerance test and HbA1c, respectively, 76 (6.6%) and 113 (9.8%) patients had diabetes, including 34 sharing both criteria; 307 (26.5%) and 478 (41.3%) had intermediate hyperglycaemia; and 130 (11.2%) and 255 (22.0%) would be treated with metformin. The sensitivity/specificity of HbA1c ≥ 6.5% (48 mmol/mol) for the diagnosis of diabetes according to the oral glucose tolerance test were 44.7/92.7%. Diabetes risk scores and UK Prospective Diabetes Study cardiovascular risk score were the highest in the 130 patients having both an abnormal oral glucose tolerance test and HbA1c ≥ 5.7%.Conclusions In a population at risk for diabetes, the HbA1c strategy could lead to diagnosing more cases of dysglycaemia and to treating more patients with metformin than the oral glucose tolerance test strategy. The consistency of either diagnostic criteria was low. The patients with the highest a priori risk of diabetes and cardiovascular disease were those fulfilling both oral glucose tolerance test and HbA1c criteria.
Druh dokumentu: Article
Jazyk: English
ISSN: 1464-5491
0742-3071
DOI: 10.1111/j.1464-5491.2010.03215.x
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/21480967
https://www.ncbi.nlm.nih.gov/pubmed/21480967
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1464-5491.2010.03215.x
Rights: Wiley Online Library User Agreement
Přístupové číslo: edsair.doi.dedup.....fab25b8f32d64c6d0b4f75fd75b966db
Databáze: OpenAIRE
Popis
Abstrakt:Diabet. Med. 28, 567–574 (2011)AbstractAims In 2010, the American Diabetes Association has published recommendations on the population to be screened for dysglycaemia; the diagnostic criteria for intermediate hyperglycaemia and diabetes using oral glucose tolerance testing and HbA1c; and the patients eligible for treatment with metformin. We aimed to evaluate the consequences of screening with oral glucose tolerance test or HbA1c in an at‐risk population.Methods Among 1177 overweight or obese consecutive adults without known diabetes who were referred to our department for weight management, we selected 1157 individuals (83% female; 80% European) fulfilling the American Diabetes Association 2010 criteria for dysglycaemia screening.Results Mean age was 41.2 ± 13 years, BMI 37.0 ± 7.2 kg/m2, fasting plasma glucose 4.9 ± 0.8 mmol/l and HbA1c (turbidimetric immunoassay) 5.7 ± 0.7% (39 mmol/mol). Based on oral glucose tolerance test and HbA1c, respectively, 76 (6.6%) and 113 (9.8%) patients had diabetes, including 34 sharing both criteria; 307 (26.5%) and 478 (41.3%) had intermediate hyperglycaemia; and 130 (11.2%) and 255 (22.0%) would be treated with metformin. The sensitivity/specificity of HbA1c ≥ 6.5% (48 mmol/mol) for the diagnosis of diabetes according to the oral glucose tolerance test were 44.7/92.7%. Diabetes risk scores and UK Prospective Diabetes Study cardiovascular risk score were the highest in the 130 patients having both an abnormal oral glucose tolerance test and HbA1c ≥ 5.7%.Conclusions In a population at risk for diabetes, the HbA1c strategy could lead to diagnosing more cases of dysglycaemia and to treating more patients with metformin than the oral glucose tolerance test strategy. The consistency of either diagnostic criteria was low. The patients with the highest a priori risk of diabetes and cardiovascular disease were those fulfilling both oral glucose tolerance test and HbA1c criteria.
ISSN:14645491
07423071
DOI:10.1111/j.1464-5491.2010.03215.x