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Evaluation of a self-administered iPad®-based processing speed assessment for people with multiple sclerosis in a clinical routine setting

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Title: Evaluation of a self-administered iPad®-based processing speed assessment for people with multiple sclerosis in a clinical routine setting
Authors: Stefanie Hechenberger, Birgit Helmlinger, Christian Tinauer, Emanuel Jauk, Stefan Ropele, Bettina Heschl, Sebastian Wurth, Anna Damulina, Sebastian Eppinger, Rina Demjaha, Michael Khalil, Christian Enzinger, Daniela Pinter
Source: J Neurol
Publisher Information: Springer Science and Business Media LLC, 2024.
Publication Year: 2024
Subject Terms: Male, Adult, Original Communication, Multiple Sclerosis, Middle Aged, Neuropsychological Tests, Magnetic Resonance Imaging, 03 medical and health sciences, 0302 clinical medicine, Computers, Handheld, Humans, Feasibility Studies, Female, Cognitive Dysfunction, Multiple Sclerosis/diagnostic imaging [MeSH], Female [MeSH], Computers, Handheld [MeSH], Aged [MeSH], Cognitive Dysfunction/diagnosis [MeSH], Adult [MeSH], Humans [MeSH], Cognitive Dysfunction/etiology [MeSH], Middle Aged [MeSH], MRI, Cognitive assessment, Processing Speed [MeSH], Feasibility Studies [MeSH], iPad, Magnetic Resonance Imaging [MeSH], Multiple sclerosis, Male [MeSH], Cognitive Dysfunction/diagnostic imaging [MeSH], Processing speed, Cognition, Neuropsychological Tests [MeSH], Aged, Processing Speed
Description: Background Limited resources often hinder regular cognitive assessment of people with multiple sclerosis (pwMS) in standard clinical care. A self-administered iPad®-based cognitive screening-tool (Processing Speed Test; PST) might mitigate this problem. Objective To evaluate the PST in clinical routine. Methods We investigated the feasibility of the PST in both a quiet and a waiting room setting. We assessed the validity of the PST in comparison with the established Symbol Digit Modalities Test (SDMT). We explored associations between processing speed assessments and the Brief International Cognitive Assessment for MS (BICAMS), magnetic resonance imaging (MRI) parameters, and psychological factors. Additionally, we explored the ability of the PST to detect impairment in processing speed compared to the SDMT. Results The PST was feasible in the waiting room setting. PST and SDMT correlated comparably with the BICAMS, MRI parameters, and psychological variables. Of 172 pwMS, 50 (30.8%) showed cognitive impairment according to the BICAMS; respective values were 47 (27.3%) for the SDMT and 9 (5.2%) for the PST. Conclusions The PST performed in a waiting room setting correlates strongly with established cognitive tests. It thus may be used to assess processing speed in a resource-efficient manner and complement cognitive assessment in clinical routine. Despite comparable validity of the PST and SDMT, we identified more pwMS with impaired processing speed using normative data of the SDMT compared to the PST and advise caution, that the common cut-off score of – 1.5 SD from the current PST is not appropriate in Europe.
Document Type: Article
Other literature type
Language: English
ISSN: 1432-1459
0340-5354
DOI: 10.1007/s00415-024-12274-8
Access URL: https://pubmed.ncbi.nlm.nih.gov/38441609
https://repository.publisso.de/resource/frl:6495645
Rights: CC BY
Accession Number: edsair.doi.dedup.....fa3d395c794cb9b3927a0e21bf0d4ed2
Database: OpenAIRE
Description
Abstract:Background Limited resources often hinder regular cognitive assessment of people with multiple sclerosis (pwMS) in standard clinical care. A self-administered iPad®-based cognitive screening-tool (Processing Speed Test; PST) might mitigate this problem. Objective To evaluate the PST in clinical routine. Methods We investigated the feasibility of the PST in both a quiet and a waiting room setting. We assessed the validity of the PST in comparison with the established Symbol Digit Modalities Test (SDMT). We explored associations between processing speed assessments and the Brief International Cognitive Assessment for MS (BICAMS), magnetic resonance imaging (MRI) parameters, and psychological factors. Additionally, we explored the ability of the PST to detect impairment in processing speed compared to the SDMT. Results The PST was feasible in the waiting room setting. PST and SDMT correlated comparably with the BICAMS, MRI parameters, and psychological variables. Of 172 pwMS, 50 (30.8%) showed cognitive impairment according to the BICAMS; respective values were 47 (27.3%) for the SDMT and 9 (5.2%) for the PST. Conclusions The PST performed in a waiting room setting correlates strongly with established cognitive tests. It thus may be used to assess processing speed in a resource-efficient manner and complement cognitive assessment in clinical routine. Despite comparable validity of the PST and SDMT, we identified more pwMS with impaired processing speed using normative data of the SDMT compared to the PST and advise caution, that the common cut-off score of – 1.5 SD from the current PST is not appropriate in Europe.
ISSN:14321459
03405354
DOI:10.1007/s00415-024-12274-8