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Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain

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Názov: Effects of adolescent social isolation on the expression of brain-derived neurotrophic factors in the forebrain
Autori: Meng, Qingxuan, Li, Nanxin, Han, Xiao, Shao, Feng, Wang, Weiwen, Shao, F (reprint author), Peking Univ, Dept Psychol, 5 Yiheyuan Rd, Beijing 100871, Peoples R China.
Zdroj: European Journal of Pharmacology. 650:229-232
Informácie o vydavateľovi: Elsevier BV, 2011.
Rok vydania: 2011
Predmety: Male, Adolescent, Hippocampus, Frontal cortex, Rats, Sprague-Dawley, 03 medical and health sciences, Prosencephalon, 0302 clinical medicine, Animals, Humans, Interpersonal Relations, 0501 psychology and cognitive sciences, 10. No inequality, Social isolation, Behavior, Animal, Brain-Derived Neurotrophic Factor, 05 social sciences, Pain Perception, Physiological Psychology/biological Psychology, Rats, 3. Good health, BDNF, Gene Expression Regulation, Social Isolation, Female
Popis: Adolescence is a critical period for the development of neural plasticity. Social isolation is an important animal model for various neurodevelopmental disorders. Brain derived neurotrophic factor (BDNF) mediates many important brain functions such as neural plasticity, and aberrations in its expression have been implicated in many brain disorders. However, to date there have been few reports of effects of adolescent social isolation on BDNF expression in adult animals. In the present study, we subjected weaning Sprague Dawley rats to a four-week early adolescence social isolation procedure followed by four-week standard housing until adulthood for molecular assays. BDNF protein levels in several key forebrain regions relevant to brain development were investigated using immunohistochemistry, including frontal and cingulate cortex as well as hippocampus. Our results show that adolescent social isolation significantly increased BDNF protein expression in the medial prefrontal cortex and all three sub-fields of the hippocampus, including CA1, CA2/3 and dentate gyrus. This study advances the use of adolescent social isolation as an animal model for studying neurobiological underpinnings of various neurodevelopmental disorders.
Druh dokumentu: Article
Jazyk: English
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2010.09.061
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/20946893
https://pubmed.ncbi.nlm.nih.gov/20946893/
https://core.ac.uk/display/155435714
http://www.ncbi.nlm.nih.gov/pubmed/20946893
https://europepmc.org/abstract/MED/20946893
https://www.sciencedirect.com/science/article/pii/S0014299910009829
Rights: Elsevier TDM
Prístupové číslo: edsair.doi.dedup.....fa2925a2a2a454c941d4fcb596544149
Databáza: OpenAIRE
Popis
Abstrakt:Adolescence is a critical period for the development of neural plasticity. Social isolation is an important animal model for various neurodevelopmental disorders. Brain derived neurotrophic factor (BDNF) mediates many important brain functions such as neural plasticity, and aberrations in its expression have been implicated in many brain disorders. However, to date there have been few reports of effects of adolescent social isolation on BDNF expression in adult animals. In the present study, we subjected weaning Sprague Dawley rats to a four-week early adolescence social isolation procedure followed by four-week standard housing until adulthood for molecular assays. BDNF protein levels in several key forebrain regions relevant to brain development were investigated using immunohistochemistry, including frontal and cingulate cortex as well as hippocampus. Our results show that adolescent social isolation significantly increased BDNF protein expression in the medial prefrontal cortex and all three sub-fields of the hippocampus, including CA1, CA2/3 and dentate gyrus. This study advances the use of adolescent social isolation as an animal model for studying neurobiological underpinnings of various neurodevelopmental disorders.
ISSN:00142999
DOI:10.1016/j.ejphar.2010.09.061