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Exploring Bidirectional Causality between Obstructive Sleep Apnea and Chronic Kidney Disease via Mendelian Randomization

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Názov: Exploring Bidirectional Causality between Obstructive Sleep Apnea and Chronic Kidney Disease via Mendelian Randomization
Autori: Xiaoning Liu, Mengna Liu, Bijuan Zhong, Xinxin He, Yalai Xu, Zheng Zhou, Pei Qin
Zdroj: Nat Sci Sleep
Nature and Science of Sleep, Vol Volume 17, Iss Issue 1, Pp 1205-1215 (2025)
Informácie o vydavateľovi: Informa UK Limited, 2025.
Rok vydania: 2025
Predmety: Mendelian randomization, Psychiatry, Neurophysiology and neuropsychology, Chronic kidney disease, Bidirectional, QP351-495, RC435-571, Obstructive sleep apnea, Renal function, Original Research
Popis: PURPOSE: It remains unclear about the causal association between obstructive sleep apnea (OSA) and chronic kidney disease (CKD) and renal function. This study aimed to explore the bidirectional causal relationship between OSA and CKD and renal function. METHODS: We used a 2-sample bidirectional Mendelian randomization (MR) method to evaluate the causal relationship between OSA and estimated glomerular filtration rate from creatinine (eGFRcrea), eGFR from cystatin C (eGFRcys), urine albumin to creatinine ratio (UACR), blood urea nitrogen (BUN), and chronic kidney disease (CKD). Inverse variance weighted (IVW), MR-Egger, weighted median, MR-Egger, and pleiotropy residual sum and outlier test (MR-PRESSO) were used to calculate the β or odds ratio [OR] and their 95% CIs. RESULTS: Genetically predicted OSA was found to be associated with BUN (β=0.040, 95% CI: 0.013–0.067, p = 0.003), but not associated with CKD (OR = 1.075, 95% CI: 0.916–1.263, p = 0.375), eGFRcrea (β=0.007, 95% CI: −0.004–0.017, p = 0.203), eGFRcys (β=−0.012, 95% CI: −0.026–0.002, p = 0.102), or UACR (β=−0.025, 95% CI: −0.058–0.007, p = 0.122). In the reverse analysis, genetically predicted eGFRcys (OR, 0.687; 95% CI, 0.497–0.950, p = 0.023) and BUN (OR, 1.686; 95% CI, 1.299–2.073, p = 0.008) was associated with an increased risk of OSA. The Cochrane’s Q test reveals significant heterogeneity between various single nucleotide polymorphisms. MR-Egger indicated no evidence of genetic pleiotropy. Results were robust using other MR methods in sensitivity analyses. CONCLUSION: Through the two-sample MR analysis, we identified kidney function may have a causal relationship with OSA, but a causal relationship between OSA and CKD and kidney function remains uncertain. More studies are required to better understand the relationship between OSA and CKD and kidney function.
Druh dokumentu: Article
Other literature type
Jazyk: English
ISSN: 1179-1608
DOI: 10.2147/nss.s503387
Prístupová URL adresa: https://doaj.org/article/a86cd032dddd4e10a74411efc4e75131
Rights: CC BY NC
URL: http://creativecommons.org/licenses/by-nc/4.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at http://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (http://www.dovepress.com/terms.php).
Prístupové číslo: edsair.doi.dedup.....fa07a0dc1005cdc01da9f8ab30f748b5
Databáza: OpenAIRE
Popis
Abstrakt:PURPOSE: It remains unclear about the causal association between obstructive sleep apnea (OSA) and chronic kidney disease (CKD) and renal function. This study aimed to explore the bidirectional causal relationship between OSA and CKD and renal function. METHODS: We used a 2-sample bidirectional Mendelian randomization (MR) method to evaluate the causal relationship between OSA and estimated glomerular filtration rate from creatinine (eGFRcrea), eGFR from cystatin C (eGFRcys), urine albumin to creatinine ratio (UACR), blood urea nitrogen (BUN), and chronic kidney disease (CKD). Inverse variance weighted (IVW), MR-Egger, weighted median, MR-Egger, and pleiotropy residual sum and outlier test (MR-PRESSO) were used to calculate the β or odds ratio [OR] and their 95% CIs. RESULTS: Genetically predicted OSA was found to be associated with BUN (β=0.040, 95% CI: 0.013–0.067, p = 0.003), but not associated with CKD (OR = 1.075, 95% CI: 0.916–1.263, p = 0.375), eGFRcrea (β=0.007, 95% CI: −0.004–0.017, p = 0.203), eGFRcys (β=−0.012, 95% CI: −0.026–0.002, p = 0.102), or UACR (β=−0.025, 95% CI: −0.058–0.007, p = 0.122). In the reverse analysis, genetically predicted eGFRcys (OR, 0.687; 95% CI, 0.497–0.950, p = 0.023) and BUN (OR, 1.686; 95% CI, 1.299–2.073, p = 0.008) was associated with an increased risk of OSA. The Cochrane’s Q test reveals significant heterogeneity between various single nucleotide polymorphisms. MR-Egger indicated no evidence of genetic pleiotropy. Results were robust using other MR methods in sensitivity analyses. CONCLUSION: Through the two-sample MR analysis, we identified kidney function may have a causal relationship with OSA, but a causal relationship between OSA and CKD and kidney function remains uncertain. More studies are required to better understand the relationship between OSA and CKD and kidney function.
ISSN:11791608
DOI:10.2147/nss.s503387