Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8
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| Název: | Household transmissibility and other characteristics of seasonal oseltamivir-resistant influenza A(H1N1) viruses, Germany, 2007-8 |
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| Autoři: | M an der Heiden, B Reinhardt, Silke Buda, S Brockmann, Brunhilde Schweiger, Susanne Duwe, Udo Buchholz |
| Zdroj: | Eurosurveillance. 15 |
| Informace o vydavateli: | European Centre for Disease Control and Prevention (ECDC), 2010. |
| Rok vydání: | 2010 |
| Témata: | Male, 0301 basic medicine, Human/epidemiology, Germany/epidemiology, Drug Resistance, 610 Medizin, Disease Outbreaks/statistics & numerical data, Antiviral Agents, Risk Assessment, Disease Outbreaks, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Influenza A Virus, H1N1 Subtype, Oseltamivir, Risk Factors, Germany, Drug Resistance, Viral, Influenza, Human, Influenza A Virus, Humans, H1N1 Subtype, Human/transmission, Viral, Oseltamivir/therapeutic use, Antiviral Agents/therapeutic use, ddc:610, 0303 health sciences, Incidence, Housing/statistics & numerical data, Influenza, 3. Good health, Housing, Female, Seasons, Human/drug therapy |
| Popis: | During the influenza season 2007-8, the proportion of seasonal influenza A(H1N1) viruses resistant to the neuraminidase inhibitor oseltamivir increased worldwide. We conducted an investigation to compare patients infected with oseltamivir-resistant (ose-R) and oseltamivir- susceptible (ose-S) influenza A(H1N1) viruses regarding risk factors for resistance and the capability to transmit in the household setting. Within a cohort of 396 laboratory confirmed influenza patients from sentinel physicians we conducted a nested case-control study among patients infected with A(H1N1). Thirty patients in the cohort were infected with influenza B, none with influenza A(H3N2) and 366 with A(H1N1). Of the 366 A(H1N1) viruses 52 (14%) were ose-R. Demographic characteristics, oseltamivir exposure, travel history and outcome were not significantly different between ose-S and ose-R patients. Among 133 households in the nested case-control study, secondary household attack rates in households with ose-R cases and households with ose-S cases were similar (23 versus 26%; p-value=0.54). Ose-R household status and occurrence of secondary cases were associated with an odds ratio of 0.85 (95% confidence interval 0.38-1.88). We conclude that seasonal ose-R influenza A(H1N1) viruses have transmitted well in the household setting. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1560-7917 |
| DOI: | 10.2807/ese.15.06.19483-en |
| DOI: | 10.25646/511 |
| Přístupová URL adresa: | https://www.eurosurveillance.org/deliver/fulltext/eurosurveillance/15/6/art19483-en.pdf?itemId=%2Fcontent%2F10.2807%2Fese.15.06.19483-en&mimeType=pdf&containerItemId=content/eurosurveillance https://pubmed.ncbi.nlm.nih.gov/20158979 https://edoc.rki.de/handle/176904/586 https://www.cabdirect.org/abstracts/20103074321.html https://www.eurosurveillance.org/content/10.2807/ese.15.06.19483-en https://www.cabdirect.org/cabdirect/abstract/20103074321 https://www.ncbi.nlm.nih.gov/pubmed/20158979 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....f9d210805861f657b2d5b495cb339740 |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | During the influenza season 2007-8, the proportion of seasonal influenza A(H1N1) viruses resistant to the neuraminidase inhibitor oseltamivir increased worldwide. We conducted an investigation to compare patients infected with oseltamivir-resistant (ose-R) and oseltamivir- susceptible (ose-S) influenza A(H1N1) viruses regarding risk factors for resistance and the capability to transmit in the household setting. Within a cohort of 396 laboratory confirmed influenza patients from sentinel physicians we conducted a nested case-control study among patients infected with A(H1N1). Thirty patients in the cohort were infected with influenza B, none with influenza A(H3N2) and 366 with A(H1N1). Of the 366 A(H1N1) viruses 52 (14%) were ose-R. Demographic characteristics, oseltamivir exposure, travel history and outcome were not significantly different between ose-S and ose-R patients. Among 133 households in the nested case-control study, secondary household attack rates in households with ose-R cases and households with ose-S cases were similar (23 versus 26%; p-value=0.54). Ose-R household status and occurrence of secondary cases were associated with an odds ratio of 0.85 (95% confidence interval 0.38-1.88). We conclude that seasonal ose-R influenza A(H1N1) viruses have transmitted well in the household setting. |
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| ISSN: | 15607917 |
| DOI: | 10.2807/ese.15.06.19483-en |