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Sex matters in the association between cardiovascular health and incident dementia: evidence from real world data

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Názov: Sex matters in the association between cardiovascular health and incident dementia: evidence from real world data
Autori: Anna Ponjoan, Jordi Blanch, Ester Fages-Masmiquel, Ruth Martí-Lluch, Lia Alves-Cabratosa, María del Mar Garcia-Gil, Gina Domínguez-Armengol, Francesc Ribas-Aulinas, Lluís Zacarías-Pons, Rafel Ramos
Prispievatelia: [Ponjoan A, Martí-Lluch R] Grup de recerca Investigació en Salut Vascular (ISV-Girona), Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Girona, Spain. Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI), Salt (Girona), Spain. Xarxa d'Investigació en Cronicitat, Atenció Primària i Promoció de la Salut (RICAPPS), Girona, Spain. [Blanch J] Grup de recerca Investigació en Salut Vascular (ISV-Girona), Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Girona, Spain. [Fages-Masmiquel E] Atenció Primària, Gerència Territorial de Girona, Institut Català de la Salut (ICS), Girona, Spain. [Alves-Cabratosa L, Garcia-Gil MM] Grup de recerca Investigació en Salut Vascular (ISV-Girona), Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Girona, Spain. [Domínguez-Armengol G, Ribas-Aulinas F, Zacarías-Pons L] Grup de recerca Investigació en Salut Vascular (ISV-Girona), Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Girona, Spain. . Xarxa d'Investigació en Cronicitat, Atenció Primària i Promoció de la Salut (RICAPPS), Girona, Spain. [Ramos R] Grup de recerca Investigació en Salut Vascular (ISV-Girona), Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Girona, Spain. Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta (IDIBGI), Salt (Girona), Spain. Xarxa d'Investigació en Cronicitat, Atenció Primària i Promoció de la Salut (RICAPPS), Girona, Spain. Atenció Primària, Gerència Territorial de Girona, Institut Català de la Salut (ICS), Girona, Spain. Translab Research Group, Department of Medical Sciences, Universitat de Girona, Girona, Spain, Departament de Salut
Zdroj: Alzheimers Res Ther
Scientia
Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)
Informácie o vydavateľovi: Springer Science and Business Media LLC, 2024.
Rok vydania: 2024
Predmety: Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología, Male, European People, Alzheimer, Malaltia d' - Factors de risc, Neurosciences. Biological psychiatry. Neuropsychiatry, Persones grans, General practitioner, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares::enfermedades arteriales intracraneales::arterioesclerosis intracraneal::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia vascular, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Risk Factors, Electronic health records, Humans, RC346-429, DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer Disease, Primary health care, Heart disease risk factors, Retrospective Studies, Aged, Research, Dementia, Vascular, Diabetes, SALUD PÚBLICA::epidemiología y bioestadística::epidemiología::medidas de asociación, exposición, riesgo o desenlace::factores de riesgo, Middle Aged, ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::demencia::enfermedad de Alzheimer, DENOMINACIONES DE GRUPOS::personas::Grupos de Edad::adulto, 3. Good health, NAMED GROUPS::Persons::Age Groups::Adult::Middle Aged, Alzheimer, Malaltia d', Family practice, Female, Neurology. Diseases of the nervous system, Other subheadings::Other subheadings::Other subheadings::/epidemiology, PUBLIC HEALTH::Epidemiology and Biostatistics::Epidemiology::Measures of Association, Exposure, Risk or Outcome::Risk Factors, Demència senil, RC321-571, DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders::Intracranial Arterial Diseases::Intracranial Arteriosclerosis::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia, Vascular
Popis: Background Cardiovascular health has been associated with dementia onset, but little is known about the variation of such association by sex and age considering dementia subtypes. We assessed the role of sex and age in the association between cardiovascular risk and the onset of all-cause dementia, Alzheimer’s disease, and vascular dementia in people aged 50–74 years. Methods This is a retrospective cohort study covering 922.973 Catalans who attended the primary care services of the Catalan Health Institute (Spain). Data were obtained from the System for the Development of Research in Primary Care (SIDIAP database). Exposure was the cardiovascular risk (CVR) at baseline categorized into four levels of Framingham-REGICOR score (FRS): low (FRS Results A total of 51,454 incident cases of all-cause dementia were recorded over a mean follow-up of 12.7 years. The hazard ratios in the low-intermediate and high FRS groups were 1.12 (95% confidence interval: 1.08–1.15) and 1.55 (1.50–1.60) for all-cause dementia; 1.07 (1.03–1.11) and 1.17 (1.11–1.24) for Alzheimer’s disease; and 1.34 (1.21–1.50) and 1.90 (1.67–2.16) for vascular dementia. These associations were stronger in women and in midlife compared to later life in all dementia types. Women with a high Framingham-REGICOR score presented a similar risk of developing dementia — of any type — to women who had previous vascular disease, and at age 50–55, they showed three times higher risk of developing dementia risk compared to the lowest Framingham-REGICOR group. Conclusions We found a dose‒response association between the Framingham-REGICOR score and the onset of all dementia types. Poor cardiovascular health in midlife increased the onset of all dementia types later in life, especially in women.
Druh dokumentu: Article
Other literature type
Popis súboru: application/pdf
Jazyk: English
ISSN: 1758-9193
DOI: 10.1186/s13195-024-01406-x
Prístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38481343
http://hdl.handle.net/11351/12854
https://doaj.org/article/23e02cc1f0a2484abc48c1bac1cc4a8e
Rights: CC BY
URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Prístupové číslo: edsair.doi.dedup.....f9c5e2021a47298343e9d33124a19af4
Databáza: OpenAIRE
Popis
Abstrakt:Background Cardiovascular health has been associated with dementia onset, but little is known about the variation of such association by sex and age considering dementia subtypes. We assessed the role of sex and age in the association between cardiovascular risk and the onset of all-cause dementia, Alzheimer’s disease, and vascular dementia in people aged 50–74 years. Methods This is a retrospective cohort study covering 922.973 Catalans who attended the primary care services of the Catalan Health Institute (Spain). Data were obtained from the System for the Development of Research in Primary Care (SIDIAP database). Exposure was the cardiovascular risk (CVR) at baseline categorized into four levels of Framingham-REGICOR score (FRS): low (FRS Results A total of 51,454 incident cases of all-cause dementia were recorded over a mean follow-up of 12.7 years. The hazard ratios in the low-intermediate and high FRS groups were 1.12 (95% confidence interval: 1.08–1.15) and 1.55 (1.50–1.60) for all-cause dementia; 1.07 (1.03–1.11) and 1.17 (1.11–1.24) for Alzheimer’s disease; and 1.34 (1.21–1.50) and 1.90 (1.67–2.16) for vascular dementia. These associations were stronger in women and in midlife compared to later life in all dementia types. Women with a high Framingham-REGICOR score presented a similar risk of developing dementia — of any type — to women who had previous vascular disease, and at age 50–55, they showed three times higher risk of developing dementia risk compared to the lowest Framingham-REGICOR group. Conclusions We found a dose‒response association between the Framingham-REGICOR score and the onset of all dementia types. Poor cardiovascular health in midlife increased the onset of all dementia types later in life, especially in women.
ISSN:17589193
DOI:10.1186/s13195-024-01406-x