Spray-dried nanocrystal-loaded polymer microparticles for long-term release local therapies: an opportunity for poorly soluble drugs
Gespeichert in:
| Titel: | Spray-dried nanocrystal-loaded polymer microparticles for long-term release local therapies: an opportunity for poorly soluble drugs |
|---|---|
| Autoren: | Rodriguez-Nogales, Carlos, Meeus, Joke, Thonus, Gaby, Corveleyn, Sam, Allémann, Eric, Jordan, Olivier |
| Quelle: | Drug Deliv Drug Delivery, Vol 30, Iss 1 (2023) |
| Verlagsinformationen: | Informa UK Limited, 2023. |
| Publikationsjahr: | 2023 |
| Schlagwörter: | microparticles, Polymers, Spray-drying, PLGA, Solvents / chemistry, RM1-950, Microparticles, Nanocrystals, Drug Delivery Systems, nanocrystals, Pharmaceutical Preparations, Drug Delivery Systems / methods, Polymers / chemistry, Osteoarthritis, Solvents, Nanoparticles, Nanoparticles / chemistry, spray-drying, Therapeutics. Pharmacology, Particle Size, Research Article |
| Beschreibung: | Nano- and micro-technologies can salvage drugs with very low solubility that were doomed to pre-clinical and clinical failure. A unique design approach to develop drug nanocrystals (NCs) loaded in extended release polymeric microparticles (MPs) for local treatments is presented here through the case of a potential osteoarthritis (OA) drug candidate for intra-articular (IA) administration. Optimizing a low-shear wet milling process allowed the production of NCs that can be subsequently freeze-dried (FD) and redispersed in a hydrophobic polymer-organic solvent solution to form spray-dried MPs. Results demonstrated a successful development of a ready-to-upscale formulation containing PLGA MPs with high drug NC encapsulation rates that showed a continuous and controlled drug release profile over four months. The screenings and procedures described allowed for identifying and overcoming common difficulties and challenges raised along the drug reduction to nano-size and spray-drying process. Above all, the technical knowledge acquired is intended for formulation scientists aiming to improve the therapeutic perspectives of poorly soluble drugs. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1521-0464 1071-7544 |
| DOI: | 10.1080/10717544.2023.2284683 |
| DOI: | 10.6084/m9.figshare.24628264 |
| DOI: | 10.6084/m9.figshare.24628264.v1 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/37994039 https://doaj.org/article/fe6ab5d8e06947deb553cce8fc7d39e1 |
| Rights: | CC BY NC CC BY URL: http://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (http://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
| Dokumentencode: | edsair.doi.dedup.....f957646c83c67d15795d971a6560218a |
| Datenbank: | OpenAIRE |
Full Text 
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstract: | Nano- and micro-technologies can salvage drugs with very low solubility that were doomed to pre-clinical and clinical failure. A unique design approach to develop drug nanocrystals (NCs) loaded in extended release polymeric microparticles (MPs) for local treatments is presented here through the case of a potential osteoarthritis (OA) drug candidate for intra-articular (IA) administration. Optimizing a low-shear wet milling process allowed the production of NCs that can be subsequently freeze-dried (FD) and redispersed in a hydrophobic polymer-organic solvent solution to form spray-dried MPs. Results demonstrated a successful development of a ready-to-upscale formulation containing PLGA MPs with high drug NC encapsulation rates that showed a continuous and controlled drug release profile over four months. The screenings and procedures described allowed for identifying and overcoming common difficulties and challenges raised along the drug reduction to nano-size and spray-drying process. Above all, the technical knowledge acquired is intended for formulation scientists aiming to improve the therapeutic perspectives of poorly soluble drugs. |
|---|---|
| ISSN: | 15210464 10717544 |
| DOI: | 10.1080/10717544.2023.2284683 |