Sensory acquisition functions of the cerebellum in verbal working memory
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| Title: | Sensory acquisition functions of the cerebellum in verbal working memory |
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| Authors: | Dominic T. Cheng, Yu Liang, John E. Desmond, Jutta Peterburs |
| Source: | Brain Struct Funct |
| Publisher Information: | Springer Science and Business Media LLC, 2021. |
| Publication Year: | 2021 |
| Subject Terms: | Adult, Male, 0301 basic medicine, Brain Mapping, Eye Movements, Middle Aged, Magnetic Resonance Imaging, Functional Laterality, 03 medical and health sciences, Memory, Short-Term, 0302 clinical medicine, Female [MeSH], Memory, Short-Term/physiology [MeSH], Photic Stimulation/methods [MeSH], Adult [MeSH], Humans [MeSH], Eye tracking, Middle Aged [MeSH], Working memory, Original Article, Male [MeSH], Eye Movements/physiology [MeSH], Cerebellum/physiology [MeSH], Brain Mapping/methods [MeSH], Magnetic Resonance Imaging/methods [MeSH], Cerebellum, Functional Laterality/physiology [MeSH], Cognition, Sensory acquisition, Humans, Female, 10. No inequality, Photic Stimulation |
| Description: | Several fMRI studies have shown that the superior cerebellum exhibits load-dependent activations during encoding of letters in a Sternberg verbal working memory (VWM) task. It has been hypothesized that the cerebellum regulates the acquisition of sensory data across all modalities, and thus, that VWM load activations may reflect high- vs low-load differences in sensory acquisition demands. Therefore, increased difficulty in sensory data acquisition should elicit greater activation in the cerebellum. The present fMRI study manipulated sensory acquisition in VWM by presenting visually degraded and non-degraded stimuli with high and low memory loads, thereby identifying load-dependent regions of interest in the cerebellum, and then testing if these regions showed greater activation for degraded stimuli. Results yielded partial support for the sensory acquisition hypothesis in a load-dependent region of the vermis, which showed significantly greater activation for degraded relative to non-degraded stimuli. Because eye movements did not differ for these stimulus types, and degradation-related activations were present after co-varying eye movements, this activation appears to be related to perceptual rather than oculomotor demands. In contrast to the vermis, load-sensitive regions of the cerebellar hemispheres did not show increased activation for degraded stimuli. These findings point to an overall function of association-based prediction that may underlie general cerebellar function, with perceptual prediction of stimuli from partial representations occurring in the vermis, and articulatory prediction occurring in the hemispheres. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1863-2661 1863-2653 |
| DOI: | 10.1007/s00429-020-02212-5 |
| Access URL: | https://link.springer.com/content/pdf/10.1007/s00429-020-02212-5.pdf https://pubmed.ncbi.nlm.nih.gov/33481104 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981326/ https://jhu.pure.elsevier.com/en/publications/sensory-acquisition-functions-of-the-cerebellum-in-verbal-working https://pubmed.ncbi.nlm.nih.gov/33481104/ https://europepmc.org/article/MED/33481104 https://link.springer.com/content/pdf/10.1007/s00429-020-02212-5.pdf https://link.springer.com/article/10.1007/s00429-020-02212-5 https://repository.publisso.de/resource/frl:6450018 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....f8352ba2fc81f69b2f88ea9071111b48 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Several fMRI studies have shown that the superior cerebellum exhibits load-dependent activations during encoding of letters in a Sternberg verbal working memory (VWM) task. It has been hypothesized that the cerebellum regulates the acquisition of sensory data across all modalities, and thus, that VWM load activations may reflect high- vs low-load differences in sensory acquisition demands. Therefore, increased difficulty in sensory data acquisition should elicit greater activation in the cerebellum. The present fMRI study manipulated sensory acquisition in VWM by presenting visually degraded and non-degraded stimuli with high and low memory loads, thereby identifying load-dependent regions of interest in the cerebellum, and then testing if these regions showed greater activation for degraded stimuli. Results yielded partial support for the sensory acquisition hypothesis in a load-dependent region of the vermis, which showed significantly greater activation for degraded relative to non-degraded stimuli. Because eye movements did not differ for these stimulus types, and degradation-related activations were present after co-varying eye movements, this activation appears to be related to perceptual rather than oculomotor demands. In contrast to the vermis, load-sensitive regions of the cerebellar hemispheres did not show increased activation for degraded stimuli. These findings point to an overall function of association-based prediction that may underlie general cerebellar function, with perceptual prediction of stimuli from partial representations occurring in the vermis, and articulatory prediction occurring in the hemispheres. |
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| ISSN: | 18632661 18632653 |
| DOI: | 10.1007/s00429-020-02212-5 |