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Predictors of non‐transplantable recurrence in hepatocellular carcinoma patients treated with frontline liver resection

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Title: Predictors of non‐transplantable recurrence in hepatocellular carcinoma patients treated with frontline liver resection
Authors: Pelizzaro, Filippo, Trevisani, Franco, Simeon, Vittorio, Vitale, Alessandro, Cillo, Umberto, Piscaglia, Fabio, Missale, Gabriele, Sangiovanni, Angelo, Foschi, Francesco G., Cabibbo, Giuseppe, Caturelli, Eugenio, Marco di, Maria, Azzaroli, Francesco, Brunetto, Maurizia R., Raimondo, Giovanni, Vidili, Gianpaolo, Guarino, Maria, Gasbarrini, Antonio, Campani, Claudia, Svegliati‐Baroni, Gianluca, Giannini, Edoardo G., Mega, Andrea, Masotto, Alberto, Rapaccini, Gian Ludovico, Magalotti, Donatella, Sacco, Rodolfo, Nardone, Gerardo, Farinati, Fabio, Saitta, Carlo, Franze' Maria Stella
Source: Liver International. 43:2762-2775
Publisher Information: Wiley, 2023.
Publication Year: 2023
Subject Terms: Settore MED/12 - Gastroenterologia, Settore MED/09 - Medicina Interna, recurrence, Carcinoma, Hepatocellular, hepatectomy, liver cancer, liver transplantation, recurrence, tumour size, liver transplantation, Settore MED/06 - Oncologia Medica, Liver Neoplasms, Liver Transplantation, 3. Good health, liver cancer, tumour size, Settore MED/18 - Chirurgia Generale, hepatectomy, Humans, Hepatectomy, alpha-Fetoproteins, Neoplasm Recurrence, Local, Retrospective Studies
Description: Background and AimsHepatocellular carcinoma (HCC) recurrence is common in patients treated with liver resection (LR). In this study, we aimed to evaluate the incidence and preoperative predictors of non‐transplantable recurrence in patients with single HCC ≤5 cm treated with frontline LR.MethodsFrom the Italian Liver Cancer (ITA.LI.CA) database, 512 patients receiving frontline LR for single HCC ≤5 cm were retrieved. Incidence and predictors of recurrence beyond Milan criteria (MC) and up‐to‐seven criteria were compared between patients with HCC ResultsDuring a median follow‐up of 4.2 years, the overall recurrence rate was 55.9%. In the ≥4 cm group, a significantly higher proportion of patients recurred beyond MC at first recurrence (28.9% vs. 14.1%; p p n = 354), microvascular invasion and microsatellite lesions were identified as additional independent risk factors for non‐transplantable recurrence.ConclusionsDespite the high recurrence rate, LR for single HCC ≤5 cm offers excellent long‐term survival. Non‐transplantable recurrence is predicted by HCC size and AFP levels, among pre‐operatively available variables. High‐risk patients could be considered for frontline LT or listed for transplantation even before recurrence.
Document Type: Article
File Description: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document
Language: English
ISSN: 1478-3231
1478-3223
DOI: 10.1111/liv.15719
Access URL: https://pubmed.ncbi.nlm.nih.gov/37753540
https://hdl.handle.net/11588/981545
https://hdl.handle.net/10447/619415
https://hdl.handle.net/11570/3287290
https://onlinelibrary.wiley.com/doi/10.1111/liv.15719
https://doi.org/10.1111/liv.15719
https://onlinelibrary.wiley.com/doi/10.1111/liv.15719
https://doi.org/10.1111/liv.15719
https://hdl.handle.net/11585/957028
https://hdl.handle.net/2158/1350058
https://doi.org/10.1111/liv.15719
Rights: CC BY
Accession Number: edsair.doi.dedup.....f71650a5fb67701fa540e333d9bbf057
Database: OpenAIRE
Description
Abstract:Background and AimsHepatocellular carcinoma (HCC) recurrence is common in patients treated with liver resection (LR). In this study, we aimed to evaluate the incidence and preoperative predictors of non‐transplantable recurrence in patients with single HCC ≤5 cm treated with frontline LR.MethodsFrom the Italian Liver Cancer (ITA.LI.CA) database, 512 patients receiving frontline LR for single HCC ≤5 cm were retrieved. Incidence and predictors of recurrence beyond Milan criteria (MC) and up‐to‐seven criteria were compared between patients with HCC ResultsDuring a median follow‐up of 4.2 years, the overall recurrence rate was 55.9%. In the ≥4 cm group, a significantly higher proportion of patients recurred beyond MC at first recurrence (28.9% vs. 14.1%; p p n = 354), microvascular invasion and microsatellite lesions were identified as additional independent risk factors for non‐transplantable recurrence.ConclusionsDespite the high recurrence rate, LR for single HCC ≤5 cm offers excellent long‐term survival. Non‐transplantable recurrence is predicted by HCC size and AFP levels, among pre‐operatively available variables. High‐risk patients could be considered for frontline LT or listed for transplantation even before recurrence.
ISSN:14783231
14783223
DOI:10.1111/liv.15719