Adverse outcome pathways: a concise introduction for toxicologists
Saved in:
| Title: | Adverse outcome pathways: a concise introduction for toxicologists |
|---|---|
| Authors: | Mathieu Vinken, Dries Knapen, Lucia Vergauwen, Jan G. Hengstler, Michelle Angrish, Maurice Whelan |
| Contributors: | Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Liver Connexin and Pannexin Research Group, Faculty of Medicine and Pharmacy, FORMER_In Vitro Toxicology and Dermato-Cosmetology |
| Source: | Archives of Toxicology |
| Publisher Information: | Springer Science and Business Media LLC, 2017. |
| Publication Year: | 2017 |
| Subject Terms: | 0301 basic medicine, 0303 health sciences, Adverse Outcome Pathways, Aromatase Inhibitors, risk assessment, Proteins, Toxicology, Ecotoxicology, Risk Assessment, adverse outcome pathway, ecotoxicology, Ecotoxicology/methods, 3. Good health, 03 medical and health sciences, Skin/drug effects, Proteins/metabolism, Animals, Humans, Aromatase Inhibitors/adverse effects, 10. No inequality, Skin |
| Description: | Adverse outcome pathways (AOPs) are designed to provide a clear-cut mechanistic representation of critical toxicological effects that propagate over different layers of biological organization from the initial interaction of a chemical with a molecular target to an adverse outcome at the individual or population level. Adverse outcome pathways are currently gaining momentum, especially in view of their many potential applications as pragmatic tools in the fields of human toxicology, ecotoxicology, and risk assessment. A number of guidance documents, issued by the Organization for Economic Cooperation and Development, as well as landmark papers, outlining best practices to develop, assess and use AOPs, have been published in the last few years. The present paper provides a synopsis of the main principles related to the AOP framework for the toxicologist less familiar with this area, followed by two case studies relevant for human toxicology and ecotoxicology. |
| Document Type: | Article |
| Language: | English |
| ISSN: | 1432-0738 0340-5761 |
| DOI: | 10.1007/s00204-017-2020-z |
| Access URL: | https://europepmc.org/articles/pmc5805086?pdf=render https://pubmed.ncbi.nlm.nih.gov/28660287 https://researchportal.vub.be/en/publications/adverse-outcome-pathways-a-concise-introduction-for-toxicologists https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805086/ https://link.springer.com/article/10.1007%2Fs00204-017-2020-z https://europepmc.org/articles/PMC5805086 https://pubmed.ncbi.nlm.nih.gov/28660287/ https://rd.springer.com/article/10.1007/s00204-017-2020-z https://biblio.vub.ac.be/vubir/adverse-outcome-pathways-a-concise-introduction-for-toxicologists(faf1d8e5-5617-4059-b243-91cfdcbf3905).html |
| Rights: | Springer TDM |
| Accession Number: | edsair.doi.dedup.....f6ef586c9ab6a655d0977ef31e9e1f33 |
| Database: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstract: | Adverse outcome pathways (AOPs) are designed to provide a clear-cut mechanistic representation of critical toxicological effects that propagate over different layers of biological organization from the initial interaction of a chemical with a molecular target to an adverse outcome at the individual or population level. Adverse outcome pathways are currently gaining momentum, especially in view of their many potential applications as pragmatic tools in the fields of human toxicology, ecotoxicology, and risk assessment. A number of guidance documents, issued by the Organization for Economic Cooperation and Development, as well as landmark papers, outlining best practices to develop, assess and use AOPs, have been published in the last few years. The present paper provides a synopsis of the main principles related to the AOP framework for the toxicologist less familiar with this area, followed by two case studies relevant for human toxicology and ecotoxicology. |
|---|---|
| ISSN: | 14320738 03405761 |
| DOI: | 10.1007/s00204-017-2020-z |