High-throughput proteomics uncovers exercise training and type 2 diabetes–induced changes in human white adipose tissue
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| Názov: | High-throughput proteomics uncovers exercise training and type 2 diabetes–induced changes in human white adipose tissue |
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| Autori: | Jeppe Kjærgaard Larsen, Rikke Kruse, Navid Sahebekhtiari, Roger Moreno-Justicia, Gerard Gomez Jorba, Maria H. Petersen, Martin E. de Almeida, Niels Ørtenblad, Atul S. Deshmukh, Kurt Højlund |
| Zdroj: | Sci Adv Larsen, J K, Kruse, R, Sahebekhtiari, N, Moreno-Justicia, R, Jorba, G G, Petersen, M H, de Almeida, M E, Ørtenblad, N, Deshmukh, A S & Højlund, K 2023, ' High-throughput proteomics uncovers exercise training and type 2 diabetes-induced changes in human white adipose tissue ', Science Advances, vol. 9, no. 48, eadi7548 . https://doi.org/10.1126/sciadv.adi7548 |
| Informácie o vydavateľovi: | American Association for the Advancement of Science (AAAS), 2023. |
| Rok vydania: | 2023 |
| Predmety: | 2. Zero hunger, Adipose Tissue/metabolism, Proteomics, Adipose Tissue, White, Ferritins/metabolism, White/metabolism, Diabetes Mellitus, Type 2, Adipose Tissue, Obesity/metabolism, Ferritins, Diabetes Mellitus, Humans, Biomedicine and Life Sciences, Obesity, Insulin Resistance, Insulin Resistance/physiology, Exercise, Type 2 |
| Popis: | White adipose tissue (WAT) is important for metabolic homeostasis. We established the differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and patients with type 2 diabetes (T2D) and the response to 8 weeks of high-intensity interval training (HIIT). Using a high-throughput and reproducible mass spectrometry–based proteomics pipeline, we identified 3773 proteins and found that most regulated proteins displayed progression in markers of dysfunctional WAT from lean to obese to T2D individuals and were highly associated with clinical measures such as insulin sensitivity and HbA1c. We propose that these distinct markers could serve as potential clinical biomarkers. HIIT induced only minor changes in the WAT proteome. This included an increase in WAT ferritin levels independent of obesity and T2D, and WAT ferritin levels were strongly correlated with individual insulin sensitivity. Together, we report a proteomic signature of WAT related to obesity and T2D and highlight an unrecognized role of human WAT iron metabolism in exercise training adaptations. |
| Druh dokumentu: | Article Other literature type |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.adi7548 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/38019916 https://curis.ku.dk/ws/files/378809990/sciadv.adi7548.pdf https://portal.findresearcher.sdu.dk/da/publications/6d1004ad-90a7-486a-87f8-5bcc14e74c38 https://doi.org/10.1126/sciadv.adi7548 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
| Prístupové číslo: | edsair.doi.dedup.....f5c6650ebfa8c10ade038cffbb6e06da |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | White adipose tissue (WAT) is important for metabolic homeostasis. We established the differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and patients with type 2 diabetes (T2D) and the response to 8 weeks of high-intensity interval training (HIIT). Using a high-throughput and reproducible mass spectrometry–based proteomics pipeline, we identified 3773 proteins and found that most regulated proteins displayed progression in markers of dysfunctional WAT from lean to obese to T2D individuals and were highly associated with clinical measures such as insulin sensitivity and HbA1c. We propose that these distinct markers could serve as potential clinical biomarkers. HIIT induced only minor changes in the WAT proteome. This included an increase in WAT ferritin levels independent of obesity and T2D, and WAT ferritin levels were strongly correlated with individual insulin sensitivity. Together, we report a proteomic signature of WAT related to obesity and T2D and highlight an unrecognized role of human WAT iron metabolism in exercise training adaptations. |
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| ISSN: | 23752548 |
| DOI: | 10.1126/sciadv.adi7548 |