Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights
Saved in:
| Title: | Targeting IspD for Anti-infective and Herbicide Development: Exploring Its Role, Mechanism, and Structural Insights |
|---|---|
| Authors: | Daan Willocx, Eleonora Diamanti, Anna K. H. Hirsch |
| Source: | J Med Chem |
| Publisher Information: | American Chemical Society (ACS), 2025. |
| Publication Year: | 2025 |
| Subject Terms: | Antimicrobial resistance, MEP pathway, IspD, anti-infectives, Enzyme Inhibitors/chemistry [MeSH], Herbicides/metabolism [MeSH], Enzyme Inhibitors/pharmacology [MeSH], Herbicides/chemical synthesis [MeSH], Perspective, Anti-Infective Agents/pharmacology [MeSH], Humans [MeSH], Herbicides/chemistry [MeSH], Anti-Infective Agents/chemistry [MeSH], Herbicides/pharmacology [MeSH], Anti-Infective Agents, Herbicides, Humans, Drug Resistance, Microbial, Enzyme Inhibitors |
| Description: | Antimicrobial resistance (AMR) and herbicide resistance pose threats to society, necessitating novel anti-infectives and herbicides exploiting untapped modes of action like inhibition of IspD, the third enzyme in the MEP pathway. The MEP pathway is essential for a wide variety of human pathogens, including Pseudomonas aeruginosa, Mycobacterium tuberculosis, and Plasmodium falciparum, as well as plants. Within the current perspective, we focused our attention on the third enzyme in this pathway, IspD, offering a comprehensive summary of the reported modes of inhibition and common trends, with the goal to inspire future research dedicated to this underexplored target. In addition, we included an overview of the history, catalytic mechanism, and structure of the enzyme to facilitate access to this attractive target. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/acs.jmedchem.4c01146 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/39749898 https://repository.publisso.de/resource/frl:6507038 https://hdl.handle.net/11585/1002835 https://doi.org/10.1021/acs.jmedchem.4c01146 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (http://creativecommons.org/licenses/by/4.0/). |
| Accession Number: | edsair.doi.dedup.....f3eddd86b615bfa13f24609ac22b78bd |
| Database: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstract: | Antimicrobial resistance (AMR) and herbicide resistance pose threats to society, necessitating novel anti-infectives and herbicides exploiting untapped modes of action like inhibition of IspD, the third enzyme in the MEP pathway. The MEP pathway is essential for a wide variety of human pathogens, including Pseudomonas aeruginosa, Mycobacterium tuberculosis, and Plasmodium falciparum, as well as plants. Within the current perspective, we focused our attention on the third enzyme in this pathway, IspD, offering a comprehensive summary of the reported modes of inhibition and common trends, with the goal to inspire future research dedicated to this underexplored target. In addition, we included an overview of the history, catalytic mechanism, and structure of the enzyme to facilitate access to this attractive target. |
|---|---|
| ISSN: | 15204804 00222623 |
| DOI: | 10.1021/acs.jmedchem.4c01146 |