In vitro testing of explanted shunt valves in hydrocephalic patients with suspected valve malfunction
Uloženo v:
| Název: | In vitro testing of explanted shunt valves in hydrocephalic patients with suspected valve malfunction |
|---|---|
| Autoři: | Bettag, Christoph, von der Brelie, Christian, Freimann, Florian Baptist, Thomale, Ulrich-Wilhelm, Rohde, Veit, Fiss, Ingo, Department of Neurosurgery, Georg-August-Universität Göttingen, Göttingen, Germany, Pediatric Neurosurgery, Charité Universitätsmedizin Berlin, Berlin, Germany |
| Přispěvatelé: | Bettag, Christoph, von der Brelie, Christian, Freimann, Florian Baptist, Thomale, Ulrich-Wilhelm, Rohde, Veit, Fiss, Ingo, Department of Neurosurgery, Georg-August-Universität Göttingen, Göttingen, Germany, Pediatric Neurosurgery, Charité Universitätsmedizin Berlin, Berlin, Germany |
| Zdroj: | Neurosurg Rev 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCP204 /20200626/ |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2021. |
| Rok vydání: | 2021 |
| Témata: | Male, 2. Zero hunger, Prostheses and Implants, In Vitro Techniques, 610 Medical sciences, Medicine, Ventriculoperitoneal Shunt, Cerebrospinal Fluid Shunts, Shunt valve, Humans [MeSH], Software [MeSH], In Vitro Techniques [MeSH], Cerebrospinal Fluid Shunts [MeSH], Prostheses and Implants [MeSH], Original Article, Hydrocephalus, Male [MeSH], Ventriculoperitoneal Shunt [MeSH], Ventriculo peritoneal shunt, Hydrocephalus/surgery [MeSH], Shunt failure, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, ddc: 610, Humans, Software |
| Popis: | Diagnosis of symptomatic valve malfunction in hydrocephalic patients treated with VP-Shunt (VPS) might be difficult. Clinical symptoms such as headache or nausea are nonspecific, hence cerebrospinal fluid (CSF) over- or underdrainage can only be suspected but not proven. Knowledge concerning valve malfunction is still limited. We aim to provide data on the flow characteristics of explanted shunt valves in patients with suspected valve malfunction. An in vitro shunt laboratory setup was used to analyze the explanted valves under conditions similar to those in an implanted VPS. The differential pressure (DP) of the valve was adjusted stepwise to 20, 10, 6, and 4 cmH2O. The flow rate of the explanted and the regular flow rate of an identical reference valve were evaluated at the respective DPs. Twelve valves of different types (Codman CertasPlus valve n = 3, Miethke Shuntassistant valve n = 4, Codman Hakim programmable valve n = 3, DP component of Miethke proGAV 2.0 valve n = 2) from eight hydrocephalic patients (four male), in whom valve malfunction was assumed between 2016 and 2017, were replaced with a new valve. Four patients suffered from idiopathic normal pressure (iNPH), three patients from malresorptive and one patient from obstructive hydrocephalus. Post-hoc analysis revealed a significant difference (p |
| Druh dokumentu: | Article Conference object Other literature type |
| Jazyk: | English |
| ISSN: | 1437-2320 0344-5607 |
| DOI: | 10.1007/s10143-021-01564-8 |
| DOI: | 10.3205/20dgnc489 |
| Přístupová URL adresa: | https://link.springer.com/content/pdf/10.1007/s10143-021-01564-8.pdf https://pubmed.ncbi.nlm.nih.gov/34027574 https://pubmed.ncbi.nlm.nih.gov/34027574/ https://europepmc.org/article/MED/34027574 https://www.scilit.net/article/500648e54d9eb79c359581741017b874?action=show-references https://link.springer.com/article/10.1007/s10143-021-01564-8 https://www.ncbi.nlm.nih.gov/pubmed/34027574 https://link.springer.com/content/pdf/10.1007/s10143-021-01564-8.pdf https://resolver.sub.uni-goettingen.de/purl?gro-2/123255 https://repository.publisso.de/resource/frl:6448887 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Přístupové číslo: | edsair.doi.dedup.....f33f69a330c19f8a7801ab7a19c96876 |
| Databáze: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstrakt: | Diagnosis of symptomatic valve malfunction in hydrocephalic patients treated with VP-Shunt (VPS) might be difficult. Clinical symptoms such as headache or nausea are nonspecific, hence cerebrospinal fluid (CSF) over- or underdrainage can only be suspected but not proven. Knowledge concerning valve malfunction is still limited. We aim to provide data on the flow characteristics of explanted shunt valves in patients with suspected valve malfunction. An in vitro shunt laboratory setup was used to analyze the explanted valves under conditions similar to those in an implanted VPS. The differential pressure (DP) of the valve was adjusted stepwise to 20, 10, 6, and 4 cmH2O. The flow rate of the explanted and the regular flow rate of an identical reference valve were evaluated at the respective DPs. Twelve valves of different types (Codman CertasPlus valve n = 3, Miethke Shuntassistant valve n = 4, Codman Hakim programmable valve n = 3, DP component of Miethke proGAV 2.0 valve n = 2) from eight hydrocephalic patients (four male), in whom valve malfunction was assumed between 2016 and 2017, were replaced with a new valve. Four patients suffered from idiopathic normal pressure (iNPH), three patients from malresorptive and one patient from obstructive hydrocephalus. Post-hoc analysis revealed a significant difference (p |
|---|---|
| ISSN: | 14372320 03445607 |
| DOI: | 10.1007/s10143-021-01564-8 |