The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants
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| Název: | The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants |
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| Autoři: | Ortgies, Tjark, Rullmann, Michael, Ziegelhöfer, Dorothée, Bläser, Annett, Thome, Ulrich H. |
| Zdroj: | BMC Pediatr BMC Pediatrics, Vol 21, Iss 1, Pp 1-13 (2021) |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2021. |
| Rok vydání: | 2021 |
| Témata: | 2. Zero hunger, Research, Developmental Disabilities, Neurodevelopment, Early-onset-Sepsis, Infant, Newborn, Infant, Infant, Newborn [MeSH], Female [MeSH], Developmental Disabilities/epidemiology [MeSH], Humans [MeSH], Cohort Studies [MeSH], Chorioamnionitis/diagnosis [MeSH], Preterm, Infant [MeSH], Sepsis/diagnosis [MeSH], Chorioamnionitis/epidemiology [MeSH], Developmental Disabilities/diagnosis [MeSH], Infant, Very Low Birth Weight [MeSH], VLBW, Child [MeSH], Pregnancy [MeSH], Developmental Disabilities/etiology [MeSH], Pediatrics, RJ1-570, 3. Good health, Cohort Studies, 03 medical and health sciences, Chorioamnionitis, 0302 clinical medicine, Pregnancy, Sepsis, Humans, Infant, Very Low Birth Weight, Female, Child, 10. No inequality |
| Popis: | Aims The study investigated a putative association between early-onset-sepsis (EOS) and poor neurodevelopmental outcomes at 2 years corrected age in very low birth weight infants. Methods This was a single-center cohort study on infants weighing less than 1500 g with a gestational age below 35 weeks at birth born between 2008 and 2011. Neurodevelopmental outcomes were assessed at follow-up with the Bayley Scales of Infant Development-II. EOS was defined as either culture-proven EOS or clinical EOS using blood culture, CrP levels, and clinical symptoms and treatment. Neurodevelopmental impairment (NDI) was defined as one or more of the following: Mental Developmental Index (MDI) and/or Psychomotor Developmental Index (PDI) scores lower than 70; presence of cerebral palsy. Results Of 405 eligible newborns in the study period 166 were included. Two had culture-proven and 29 clinical EOS. Median MDI scores in patients with EOS were 96 (IQR: 86–106) and in the control group 94 (84–106, p = 0.77). PDI scores in patients with EOS were 96 (86–106) and in the control group 99,5 (92–103, p = 0.03). Of infected patients 7/31 (24%) showed NDI as defined, whereas only 11/135 (8%) showed NDI in the control group (OR 3.3, p = 0.03). Multiple regression analyses identified chorioamnionitis and poor CRIB-Scores as individual risk factors for MDI or PDI values Conclusion In our study, EOS among VLBW-infants significantly impaired the neurodevelopment at 2 years corrected age. As shown in previous reports infection continues to be a problem and strategies for a reduction need further improvement. |
| Druh dokumentu: | Article Conference object Other literature type |
| Jazyk: | English |
| ISSN: | 1471-2431 |
| DOI: | 10.1186/s12887-021-02738-5 |
| Přístupová URL adresa: | https://bmcpediatr.biomedcentral.com/track/pdf/10.1186/s12887-021-02738-5 https://pubmed.ncbi.nlm.nih.gov/34172028 https://doaj.org/article/f014daa1c53843ca801a3ecb977b01e4 https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887-021-02738-5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229301 https://www.mendeley.com/catalogue/4298ac27-3e9f-35eb-b62a-23f08f4b1d0f/ https://link.springer.com/content/pdf/10.1186/s12887-021-02738-5.pdf https://pubmed.ncbi.nlm.nih.gov/34172028/ http://www.ncbi.nlm.nih.gov/pubmed/34172028 https://repository.publisso.de/resource/frl:6462419 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....f1d195e44d5184913ddff2f1fc608d85 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Aims The study investigated a putative association between early-onset-sepsis (EOS) and poor neurodevelopmental outcomes at 2 years corrected age in very low birth weight infants. Methods This was a single-center cohort study on infants weighing less than 1500 g with a gestational age below 35 weeks at birth born between 2008 and 2011. Neurodevelopmental outcomes were assessed at follow-up with the Bayley Scales of Infant Development-II. EOS was defined as either culture-proven EOS or clinical EOS using blood culture, CrP levels, and clinical symptoms and treatment. Neurodevelopmental impairment (NDI) was defined as one or more of the following: Mental Developmental Index (MDI) and/or Psychomotor Developmental Index (PDI) scores lower than 70; presence of cerebral palsy. Results Of 405 eligible newborns in the study period 166 were included. Two had culture-proven and 29 clinical EOS. Median MDI scores in patients with EOS were 96 (IQR: 86–106) and in the control group 94 (84–106, p = 0.77). PDI scores in patients with EOS were 96 (86–106) and in the control group 99,5 (92–103, p = 0.03). Of infected patients 7/31 (24%) showed NDI as defined, whereas only 11/135 (8%) showed NDI in the control group (OR 3.3, p = 0.03). Multiple regression analyses identified chorioamnionitis and poor CRIB-Scores as individual risk factors for MDI or PDI values Conclusion In our study, EOS among VLBW-infants significantly impaired the neurodevelopment at 2 years corrected age. As shown in previous reports infection continues to be a problem and strategies for a reduction need further improvement. |
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| ISSN: | 14712431 |
| DOI: | 10.1186/s12887-021-02738-5 |