Diagnostic Performance of Cerebrospinal Fluid Neurofilament Light Chain and Soluble Amyloid-β Protein Precursor β in the Subcortical Small Vessel Type of Dementia
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| Název: | Diagnostic Performance of Cerebrospinal Fluid Neurofilament Light Chain and Soluble Amyloid-β Protein Precursor β in the Subcortical Small Vessel Type of Dementia |
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| Autoři: | Axelsson Andrén, Elin, Kettunen, Petronella, Bjerke, Maria, Rolstad, Sindre, Zetterberg, Henrik, Blennow, Kaj, Wallin, Anders, Svensson, Johan |
| Přispěvatelé: | Neuroprotection & Neuromodulation, Clinical Biology, Clinical sciences, FORMER_Neuroprotection & Neuromodulation |
| Zdroj: | J Alzheimers Dis Journal of Alzheimer's disease Journal of Alzheimer's Disease |
| Informace o vydavateli: | SAGE Publications, 2023. |
| Rok vydání: | 2023 |
| Témata: | Alzheimer Disease/diagnosis, intermediate filaments, Amyloid beta-Peptides, Intermediate Filaments, tau Proteins/cerebrospinal fluid, tau Proteins, Amyloid beta-Peptides/cerebrospinal fluid, 3. Good health, Amyloid beta-Protein Precursor, Amyloid beta-Protein Precursor/cerebrospinal fluid, Dementia/diagnosis, Neurofilament Proteins/cerebrospinal fluid, Alzheimer Disease, Neurofilament Proteins, Humans, Biomarkers/cerebrospinal fluid, Dementia, Human medicine, Mixed Dementias, Biomarkers, Research Article |
| Popis: | Background: The subcortical small vessel type of dementia (SSVD) is a common subtype of vascular dementia, but there is a lack of disease-specific cerebrospinal fluid (CSF) biomarkers. Objective: We investigated whether CSF concentrations of neurofilament light chain (NFL), soluble amyloid-β protein precursor α (sAβPPα), sAβPPβ, and CSF/serum albumin ratio could separate SSVD from healthy controls, Alzheimer’s disease (AD), and mixed dementia (combined AD and SSVD). Methods: This was a mono-center study of patients with SSVD (n = 38), AD (n = 121), mixed dementia (n = 62), and controls (n = 96). The CSF biomarkers were measured using immunoassays, and their independent contribution to the separation between groups were evaluated using the Wald test. Then, the area under the receiver operating characteristics curve (AUROC) and 95% confidence intervals (CIs) were calculated. Results: Elevated neurofilament light chain (NFL) and decreased sAβPPβ independently separated SSVD from controls, and sAβPPβ also distinguished SSVD from AD and mixed dementia. The combination of NFL and sAβPPβ discriminated SSVD from controls with high accuracy (AUROC 0.903, 95% CI: 0.834–0.972). Additionally, sAβPPβ combined with the core AD biomarkers (amyloid-β42, total tau, and phosphorylated tau181) had a high ability to separate SSVD from AD (AUROC 0.886, 95% CI: 0.830–0.942) and mixed dementia (AUROC 0.903, 95% CI: 0.838–0.968). Conclusions: The high accuracy of NFL and sAβPPβ to separate SSVD from controls supports that SSVD is a specific diagnostic entity. Moreover, SSVD was distinguished from AD and mixed dementia using sAβPPβ in combination with the core AD biomarkers. |
| Druh dokumentu: | Article Other literature type |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-230680 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/37980667 https://hdl.handle.net/10067/2038880151162165141 https://repository.uantwerpen.be/docstore/d:irua:22335 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY 4.0) License (http://creativecommons.org/licenses/by/4.0/) |
| Přístupové číslo: | edsair.doi.dedup.....f1c20e624be1e68de6fed7507c50714e |
| Databáze: | OpenAIRE |
Nájsť tento článok vo Web of Science | Abstrakt: | Background: The subcortical small vessel type of dementia (SSVD) is a common subtype of vascular dementia, but there is a lack of disease-specific cerebrospinal fluid (CSF) biomarkers. Objective: We investigated whether CSF concentrations of neurofilament light chain (NFL), soluble amyloid-β protein precursor α (sAβPPα), sAβPPβ, and CSF/serum albumin ratio could separate SSVD from healthy controls, Alzheimer’s disease (AD), and mixed dementia (combined AD and SSVD). Methods: This was a mono-center study of patients with SSVD (n = 38), AD (n = 121), mixed dementia (n = 62), and controls (n = 96). The CSF biomarkers were measured using immunoassays, and their independent contribution to the separation between groups were evaluated using the Wald test. Then, the area under the receiver operating characteristics curve (AUROC) and 95% confidence intervals (CIs) were calculated. Results: Elevated neurofilament light chain (NFL) and decreased sAβPPβ independently separated SSVD from controls, and sAβPPβ also distinguished SSVD from AD and mixed dementia. The combination of NFL and sAβPPβ discriminated SSVD from controls with high accuracy (AUROC 0.903, 95% CI: 0.834–0.972). Additionally, sAβPPβ combined with the core AD biomarkers (amyloid-β42, total tau, and phosphorylated tau181) had a high ability to separate SSVD from AD (AUROC 0.886, 95% CI: 0.830–0.942) and mixed dementia (AUROC 0.903, 95% CI: 0.838–0.968). Conclusions: The high accuracy of NFL and sAβPPβ to separate SSVD from controls supports that SSVD is a specific diagnostic entity. Moreover, SSVD was distinguished from AD and mixed dementia using sAβPPβ in combination with the core AD biomarkers. |
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| ISSN: | 18758908 13872877 |
| DOI: | 10.3233/jad-230680 |