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Assessing vaccine-induced immunity against pneumococcus, hepatitis A and B over a 9-year follow-up in pediatric liver transplant recipients: A nationwide retrospective study

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Název: Assessing vaccine-induced immunity against pneumococcus, hepatitis A and B over a 9-year follow-up in pediatric liver transplant recipients: A nationwide retrospective study
Autoři: Temisan Gold, Renato Gualtieri, Klara Posfay-Barbe, Barbara E. Wildhaber, Valérie McLin, Geraldine Blanchard-Rohner
Zdroj: American Journal of Transplantation. 24:1070-1079
Informace o vydavateli: Elsevier BV, 2024.
Rok vydání: 2024
Témata: Male, Hepatitis B virus, Hepatitis B / prevention & control, Pneumococcal Infections / prevention & control, Adolescent, Hepatitis A Vaccines / administration & dosage, Pneumococcal Infections, Hepatitis A / immunology, Hepatitis B Vaccines / administration & dosage, Hepatitis B Vaccines / immunology, Pneumococcal Infections / immunology, Humans, Hepatitis B Vaccines, Child, Liver transplant, Retrospective Studies, Pediatric, Hepatitis A / prevention & control, Hepatitis A Vaccines, Hepatitis A Vaccines / immunology, Vaccination, Infant, Invasive pneumococcal disease, Hepatitis A virus / immunology, Hepatitis A, Hepatitis B, Prognosis, Hepatitis B virus / immunology, Transplant Recipients, Hepatitis B / immunology, Liver Transplantation, Postoperative Complications / immunology, Streptococcus pneumoniae, Child, Preschool, Streptococcus pneumoniae / immunology, Female, Infection, Follow-Up Studies
Popis: Pediatric liver transplant recipients are particularly at risk of infections. The most cost-effective way to prevent infectious complications is through vaccination, which can potentially prevent infections due to hepatitis B (HBV) virus, hepatitis A virus (HAV), and invasive pneumococcal diseases. Here, we performed a retrospective analysis of HBV, HAV, and pneumococcal immunity in pediatric liver transplant recipients between January 1, 2009, and December 31, 2020, to collect data on immunization and vaccine serology. A total of 94% (58/62) patients had available vaccination records. At transplant, 90% (45/50) were seroprotected against HBV, 63% (19/30) against HAV, and 78% (18/23) had pneumococcal immunity, but immunity against these 3 pathogens remained suboptimal during the 9-year follow-up. A booster vaccine was administered to only 20% to 40% of patients. Children who had received >4 doses of HBV vaccine and > 2 doses of HAV vaccine pretransplant displayed a higher overall seroprotection over time post-solid organ transplant. Our findings suggest that a serology-based approach should be accompanied by a more systematic follow-up of vaccination, with special attention paid to patients with an incomplete vaccination status at time of transplant.
Druh dokumentu: Article
Popis souboru: application/pdf
Jazyk: English
ISSN: 1600-6135
DOI: 10.1016/j.ajt.2023.12.011
Přístupová URL adresa: https://pubmed.ncbi.nlm.nih.gov/38103788
https://archive-ouverte.unige.ch/unige:180595
https://doi.org/10.1016/j.ajt.2023.12.011
Rights: CC BY NC ND
Přístupové číslo: edsair.doi.dedup.....f16f80dd4b1804bd2ff933c84f222000
Databáze: OpenAIRE
Popis
Abstrakt:Pediatric liver transplant recipients are particularly at risk of infections. The most cost-effective way to prevent infectious complications is through vaccination, which can potentially prevent infections due to hepatitis B (HBV) virus, hepatitis A virus (HAV), and invasive pneumococcal diseases. Here, we performed a retrospective analysis of HBV, HAV, and pneumococcal immunity in pediatric liver transplant recipients between January 1, 2009, and December 31, 2020, to collect data on immunization and vaccine serology. A total of 94% (58/62) patients had available vaccination records. At transplant, 90% (45/50) were seroprotected against HBV, 63% (19/30) against HAV, and 78% (18/23) had pneumococcal immunity, but immunity against these 3 pathogens remained suboptimal during the 9-year follow-up. A booster vaccine was administered to only 20% to 40% of patients. Children who had received >4 doses of HBV vaccine and > 2 doses of HAV vaccine pretransplant displayed a higher overall seroprotection over time post-solid organ transplant. Our findings suggest that a serology-based approach should be accompanied by a more systematic follow-up of vaccination, with special attention paid to patients with an incomplete vaccination status at time of transplant.
ISSN:16006135
DOI:10.1016/j.ajt.2023.12.011