The contribution of morbidity and unemployment for the reduced labor market participation of individuals with neurofibromatosis 1 in Finland
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| Název: | The contribution of morbidity and unemployment for the reduced labor market participation of individuals with neurofibromatosis 1 in Finland |
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| Autoři: | Roope A. Kallionpää, Edvard Johansson, Petri Böckerman, Juha Peltonen, Sirkku Peltonen |
| Přispěvatelé: | Department of Dermatology, Allergology and Venereology, Clinicum, HUS Inflammation Center |
| Zdroj: | Eur J Hum Genet |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2023. |
| Rok vydání: | 2023 |
| Témata: | Risk, Persons with Disabilities, Neurofibromatosis 1, Economics, neurofibromatoosi, työmarkkinat, Type-1, hermoston taudit, Gene, sairauspoissaolot, Article, työmarkkina-asema, Cohort Studies, Life, Adults, sairaudet, Humans, Taloustiede, Mortality, Children, Finland, 692/699/67/2324, 631/67/2324, Unemployment/psychology [MeSH], Humans [MeSH], Neurofibromatosis 1/epidemiology [MeSH], Finland/epidemiology [MeSH], Cohort Studies [MeSH], 692/308/174, 631/208/2489, Disabled Persons/psychology [MeSH], Morbidity [MeSH], 692/700/3934, article, sairastavuus, 1. No poverty, Päätöksentekoa tukeva taloustiede ja talouden kilpailukyky (painoala), ta3142, työttömyys, 16. Peace & justice, General medicine, internal medicine and other clinical medicine, 3. Good health, neurodegeneratiiviset sairaudet, Genetics, developmental biology, physiology, Unemployment, 8. Economic growth, Policy-Relevant Economics and Competitiveness of Economy (focus area), Morbidity |
| Popis: | Neurofibromatosis 1 (NF1) is a multisystem disorder associated with, for example, a high risk for cancer, a variety of behavioral and cognitive deficits, low educational attainment and decreased income. We now examined the labor market participation of individuals with NF1. We analyzed the numbers of days of work, unemployment, and sickness allowance among 742 Finnish individuals with NF1 aged 20–59 years using nationwide register data from Statistics Finland and the Social Insurance Institution of Finland. The individuals with NF1 were compared with a control cohort of 8716 individuals matched with age, sex, and the area of residence. Individuals with NF1 had a significantly lower number of working days per year than the controls (rate ratio [RR] 0.93, 95% CI 0.91–0.95). Unemployment (RR 1.79, 95% CI 1.58–2.02), and sickness absence (RR 1.44, 95% CI 1.25–1.67) were more frequent in the NF1 than in the control group. The causes of sickness allowances were highly concordant with the previously reported morbidity profile of NF1 including neoplasms, cardiovascular disease, mental and behavioral diseases, and neurological diseases. In conclusion, NF1 significantly interferes with labor market participation via both unemployment and morbidity. Unemployment seems to cause more days of not working than sickness absence. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf; fulltext |
| Jazyk: | English |
| ISSN: | 1476-5438 1018-4813 |
| DOI: | 10.1038/s41431-023-01426-5 |
| DOI: | 10.1038/s41431023014265 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/37460655 http://juuli.fi/Record/0676175723 https://doi.org/10.1038/s41431023014265 http://urn.fi/URN:NBN:fi:jyu-202308244770 http://hdl.handle.net/10138/568382 https://repository.publisso.de/resource/frl:6504749 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....f0e02a76676e89631ef20f9bd97cbb8d |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Neurofibromatosis 1 (NF1) is a multisystem disorder associated with, for example, a high risk for cancer, a variety of behavioral and cognitive deficits, low educational attainment and decreased income. We now examined the labor market participation of individuals with NF1. We analyzed the numbers of days of work, unemployment, and sickness allowance among 742 Finnish individuals with NF1 aged 20–59 years using nationwide register data from Statistics Finland and the Social Insurance Institution of Finland. The individuals with NF1 were compared with a control cohort of 8716 individuals matched with age, sex, and the area of residence. Individuals with NF1 had a significantly lower number of working days per year than the controls (rate ratio [RR] 0.93, 95% CI 0.91–0.95). Unemployment (RR 1.79, 95% CI 1.58–2.02), and sickness absence (RR 1.44, 95% CI 1.25–1.67) were more frequent in the NF1 than in the control group. The causes of sickness allowances were highly concordant with the previously reported morbidity profile of NF1 including neoplasms, cardiovascular disease, mental and behavioral diseases, and neurological diseases. In conclusion, NF1 significantly interferes with labor market participation via both unemployment and morbidity. Unemployment seems to cause more days of not working than sickness absence. |
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| ISSN: | 14765438 10184813 |
| DOI: | 10.1038/s41431-023-01426-5 |