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The contribution of morbidity and unemployment for the reduced labor market participation of individuals with neurofibromatosis 1 in Finland

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Titel: The contribution of morbidity and unemployment for the reduced labor market participation of individuals with neurofibromatosis 1 in Finland
Autoren: Roope A. Kallionpää, Edvard Johansson, Petri Böckerman, Juha Peltonen, Sirkku Peltonen
Weitere Verfasser: Department of Dermatology, Allergology and Venereology, Clinicum, HUS Inflammation Center
Quelle: Eur J Hum Genet
Verlagsinformationen: Springer Science and Business Media LLC, 2023.
Publikationsjahr: 2023
Schlagwörter: Risk, Persons with Disabilities, Neurofibromatosis 1, Economics, neurofibromatoosi, työmarkkinat, Type-1, hermoston taudit, Gene, sairauspoissaolot, Article, työmarkkina-asema, Cohort Studies, Life, Adults, sairaudet, Humans, Taloustiede, Mortality, Children, Finland, 692/699/67/2324, 631/67/2324, Unemployment/psychology [MeSH], Humans [MeSH], Neurofibromatosis 1/epidemiology [MeSH], Finland/epidemiology [MeSH], Cohort Studies [MeSH], 692/308/174, 631/208/2489, Disabled Persons/psychology [MeSH], Morbidity [MeSH], 692/700/3934, article, sairastavuus, 1. No poverty, Päätöksentekoa tukeva taloustiede ja talouden kilpailukyky (painoala), ta3142, työttömyys, 16. Peace & justice, General medicine, internal medicine and other clinical medicine, 3. Good health, neurodegeneratiiviset sairaudet, Genetics, developmental biology, physiology, Unemployment, 8. Economic growth, Policy-Relevant Economics and Competitiveness of Economy (focus area), Morbidity
Beschreibung: Neurofibromatosis 1 (NF1) is a multisystem disorder associated with, for example, a high risk for cancer, a variety of behavioral and cognitive deficits, low educational attainment and decreased income. We now examined the labor market participation of individuals with NF1. We analyzed the numbers of days of work, unemployment, and sickness allowance among 742 Finnish individuals with NF1 aged 20–59 years using nationwide register data from Statistics Finland and the Social Insurance Institution of Finland. The individuals with NF1 were compared with a control cohort of 8716 individuals matched with age, sex, and the area of residence. Individuals with NF1 had a significantly lower number of working days per year than the controls (rate ratio [RR] 0.93, 95% CI 0.91–0.95). Unemployment (RR 1.79, 95% CI 1.58–2.02), and sickness absence (RR 1.44, 95% CI 1.25–1.67) were more frequent in the NF1 than in the control group. The causes of sickness allowances were highly concordant with the previously reported morbidity profile of NF1 including neoplasms, cardiovascular disease, mental and behavioral diseases, and neurological diseases. In conclusion, NF1 significantly interferes with labor market participation via both unemployment and morbidity. Unemployment seems to cause more days of not working than sickness absence.
Publikationsart: Article
Other literature type
Dateibeschreibung: application/pdf; fulltext
Sprache: English
ISSN: 1476-5438
1018-4813
DOI: 10.1038/s41431-023-01426-5
DOI: 10.1038/s41431023014265
Zugangs-URL: https://pubmed.ncbi.nlm.nih.gov/37460655
http://juuli.fi/Record/0676175723
https://doi.org/10.1038/s41431023014265
http://urn.fi/URN:NBN:fi:jyu-202308244770
http://hdl.handle.net/10138/568382
https://repository.publisso.de/resource/frl:6504749
Rights: CC BY
Dokumentencode: edsair.doi.dedup.....f0e02a76676e89631ef20f9bd97cbb8d
Datenbank: OpenAIRE
Beschreibung
Abstract:Neurofibromatosis 1 (NF1) is a multisystem disorder associated with, for example, a high risk for cancer, a variety of behavioral and cognitive deficits, low educational attainment and decreased income. We now examined the labor market participation of individuals with NF1. We analyzed the numbers of days of work, unemployment, and sickness allowance among 742 Finnish individuals with NF1 aged 20–59 years using nationwide register data from Statistics Finland and the Social Insurance Institution of Finland. The individuals with NF1 were compared with a control cohort of 8716 individuals matched with age, sex, and the area of residence. Individuals with NF1 had a significantly lower number of working days per year than the controls (rate ratio [RR] 0.93, 95% CI 0.91–0.95). Unemployment (RR 1.79, 95% CI 1.58–2.02), and sickness absence (RR 1.44, 95% CI 1.25–1.67) were more frequent in the NF1 than in the control group. The causes of sickness allowances were highly concordant with the previously reported morbidity profile of NF1 including neoplasms, cardiovascular disease, mental and behavioral diseases, and neurological diseases. In conclusion, NF1 significantly interferes with labor market participation via both unemployment and morbidity. Unemployment seems to cause more days of not working than sickness absence.
ISSN:14765438
10184813
DOI:10.1038/s41431-023-01426-5