Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome — Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children
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| Názov: | Epidemiological and Clinical Profile of Pediatric Inflammatory Multisystem Syndrome — Temporally Associated with SARS-CoV-2 (PIMS-TS) in Indian Children |
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| Autori: | Dhanalakshmi, K, Venkataraman, Aishwarya, Balasubramanian, S, Madhusudan, Manoj, Amperayani, Sumanth, Putilibai, Sulochana, Sadasivam, Kalaimaran, Ramachandran, Bala, Ramanan, A V |
| Zdroj: | Indian Pediatr |
| Informácie o vydavateľovi: | Springer Science and Business Media LLC, 2020. |
| Rok vydania: | 2020 |
| Predmety: | Glucocorticoids/therapeutic use, Male, COVID-19/diagnosis, Adolescent, Fever, Humanized/therapeutic use, Platelet Aggregation Inhibitors/therapeutic use, Immunoglobulins, India, Blood Coagulation Disorders/etiology, Antibodies, Monoclonal, Humanized, Intensive Care Units, Pediatric, Patient Admission/statistics & numerical data, Antibodies, C-Reactive Protein/analysis, 03 medical and health sciences, Patient Admission, 0302 clinical medicine, Monoclonal, Humans, International Normalized Ratio, Preschool, Child, Glucocorticoids, Systemic Inflammatory Response Syndrome/diagnosis, Pediatric, Aspirin, SARS-CoV-2, COVID-19, Immunoglobulins, Intravenous, Infant, Blood Coagulation Disorders, 3. Good health, Fever/etiology, India/epidemiology, Intensive Care Units, C-Reactive Protein, Child, Preschool, Aspirin/therapeutic use, Prothrombin Time, Female, Intravenous/therapeutic use, Platelet Aggregation Inhibitors, Research Paper |
| Popis: | We describe the demographic, clinical and labo-ratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS).We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020.We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths.Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies. |
| Druh dokumentu: | Article Other literature type |
| Jazyk: | English |
| ISSN: | 0974-7559 0019-6061 |
| DOI: | 10.1007/s13312-020-2025-1 |
| Prístupová URL adresa: | https://link.springer.com/content/pdf/10.1007/s13312-020-2025-1.pdf https://pubmed.ncbi.nlm.nih.gov/32769230 https://europepmc.org/article/PMC/PMC7678572 https://link.springer.com/article/10.1007/s13312-020-2025-1 https://link.springer.com/content/pdf/10.1007/s13312-020-2025-1.pdf https://pubmed.ncbi.nlm.nih.gov/32769230/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678572 |
| Rights: | Springer Nature TDM |
| Prístupové číslo: | edsair.doi.dedup.....f098adf610a814dcf9605fa5094860db |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | We describe the demographic, clinical and labo-ratory findings along with the treatment and outcomes among children meeting the case definition of Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SARS-CoV-2 (PIMS-TS).We analyzed the clinical and laboratory findings of children who presented with PIMS-TS during an 8-week period from May 4, 2020 to July 8, 2020.We report 19 children with a median age of 6 year (IQR: 13 months-16 years), who met the case definition of PIMS-TS. All of them presented with fever. Multi organ involvement (79%), mucocutaneous involvement (74%), cardiovascular symptoms (63%) and gastrointestinal symptoms (42%) were the other features. Elevated levels of C-reactive protein was found in all of them and the majority of them had evidence of coagulopathy; intensive care admissions were needed in 12 (63%) and vasoactive medications were given to 6 (31.5%) children. There were no deaths.Children with PIMS-TS present with a wide range of signs and symptoms. Fewer children in this series had coronary artery abnormalities, and there was a low incidence of RT-PCR positivity with high presence of SARS-CoV-2 antibodies. |
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| ISSN: | 09747559 00196061 |
| DOI: | 10.1007/s13312-020-2025-1 |