Clinical phenotype modulates brain’s myelin and iron content in temporal lobe epilepsy
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| Titel: | Clinical phenotype modulates brain’s myelin and iron content in temporal lobe epilepsy |
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| Autoren: | Antoine Lutti, Bogdan Draganski, Andrea O. Rossetti, Roland Wiest, Elisabeth Roggenhofer, Margitta Seeck, Evdokia Toumpouli, Ferath Kherif, Jan Novy |
| Quelle: | Brain Struct Funct Brain Structure & Function Brain structure & function, vol. 227, no. 3, pp. 901-911 Roggenhofer, Elisabeth; Toumpouli, Evdokia; Seeck, Margitta; Wiest, Roland; Lutti, Antoine; Kherif, Ferath; Novy, Jan; Rossetti, Andrea O; Draganski, Bogdan (2022). Clinical phenotype modulates brain's myelin and iron content in temporal lobe epilepsy. Brain structure & function, 227(3), pp. 901-911. Springer 10.1007/s00429-021-02428-z <http://dx.doi.org/10.1007/s00429-021-02428-z> MPG.PuRe ORCID Microsoft Academic Graph Bern Open Repository and Information System (BORIS) Datacite |
| Verlagsinformationen: | Springer Science and Business Media LLC, 2021. |
| Publikationsjahr: | 2021 |
| Schlagwörter: | 0301 basic medicine, Pathology, Relaxometry, Histology, Neurology, qMRI, Brain plasticity, Brain/pathology [MeSH], Brain/diagnostic imaging [MeSH], Humans [MeSH], Iron [MeSH], Cross-Sectional Studies [MeSH], Mesial temporal lobe, Microstructural tissue property, Myelin Sheath [MeSH], Voxel-based quantification, Epilepsy, Temporal Lobe/pathology [MeSH], Original Article, Temporal lobe epilepsy, Hippocampus/pathology [MeSH], Quantitative magnetic resonance imaging, Magnetic Resonance Imaging/methods [MeSH], Phenotype [MeSH], Hippocampus/diagnostic imaging [MeSH], Epilepsy, Temporal Lobe/diagnostic imaging [MeSH], Iron, Hippocampus, 610 Medicine & health, Grey matter, Temporal lobe, Epilepsy, 03 medical and health sciences, 0302 clinical medicine, Neuroplasticity, Humans, Myelin Sheath, General Neuroscience, Brain, Magnetic resonance imaging, Magnetic Resonance Imaging, Cross-Sectional Studies, Phenotype, Epilepsy, Temporal Lobe, Anatomy, Brain/diagnostic imaging, Brain/pathology, Epilepsy, Temporal Lobe/diagnostic imaging, Epilepsy, Temporal Lobe/pathology, Hippocampus/diagnostic imaging, Hippocampus/pathology, Magnetic Resonance Imaging/methods |
| Beschreibung: | Temporal lobe epilepsy (TLE) is associated with brain pathology extending beyond temporal lobe structures. We sought to look for informative patterns of brain tissue properties in TLE that go beyond the established morphometry differences. We hypothesised that volume differences, particularly in hippocampus, will be paralleled by changes in brain microstructure. The cross-sectional study included TLE patients (n = 25) from a primary care center and sex-/age-matched healthy controls (n = 55). We acquired quantitative relaxometry-based magnetic resonance imaging (MRI) data yielding whole-brain maps of grey matter volume, magnetization transfer (MT) saturation, and effective transverse relaxation rate R2* indicative for brain tissue myelin and iron content. For statistical analysis, we used the computational anatomy framework of voxel-based morphometry and voxel-based quantification. There was a positive correlation between seizure activity and MT saturation measures in the ipsilateral hippocampus, paralleled by volume differences bilaterally. Disease duration correlated positively with iron content in the mesial temporal lobe, while seizure freedom was associated with a decrease of iron in the very same region. Our findings demonstrate the link between TLE clinical phenotype and brain anatomy beyond morphometry differences to show the impact of disease burden on specific tissue properties. We provide direct evidence for the differential effect of clinical phenotype characteristics on processes involving tissue myelin and iron in mesial temporal lobe structures. This study offers a proof-of-concept for the investigation of novel imaging biomarkers in focal epilepsy. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf |
| Sprache: | English |
| ISSN: | 1863-2661 1863-2653 |
| DOI: | 10.1007/s00429-021-02428-z |
| DOI: | 10.48350/162101 |
| Zugangs-URL: | https://link.springer.com/content/pdf/10.1007/s00429-021-02428-z.pdf https://pubmed.ncbi.nlm.nih.gov/34817680 https://www.ncbi.nlm.nih.gov/pubmed/34817680 https://pubmed.ncbi.nlm.nih.gov/34817680/ https://link.springer.com/content/pdf/10.1007/s00429-021-02428-z.pdf https://link.springer.com/article/10.1007/s00429-021-02428-z http://hdl.handle.net/21.11116/0000-0009-9B0E-A http://hdl.handle.net/21.11116/0000-0009-9B10-6 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_F3CBCCE0919E8 https://serval.unil.ch/notice/serval:BIB_F3CBCCE0919E https://serval.unil.ch/resource/serval:BIB_F3CBCCE0919E.P001/REF.pdf https://boris.unibe.ch/162101/ https://repository.publisso.de/resource/frl:6449992 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Dokumentencode: | edsair.doi.dedup.....f09453af6e0823b8571c88d3749f520f |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Temporal lobe epilepsy (TLE) is associated with brain pathology extending beyond temporal lobe structures. We sought to look for informative patterns of brain tissue properties in TLE that go beyond the established morphometry differences. We hypothesised that volume differences, particularly in hippocampus, will be paralleled by changes in brain microstructure. The cross-sectional study included TLE patients (n = 25) from a primary care center and sex-/age-matched healthy controls (n = 55). We acquired quantitative relaxometry-based magnetic resonance imaging (MRI) data yielding whole-brain maps of grey matter volume, magnetization transfer (MT) saturation, and effective transverse relaxation rate R2* indicative for brain tissue myelin and iron content. For statistical analysis, we used the computational anatomy framework of voxel-based morphometry and voxel-based quantification. There was a positive correlation between seizure activity and MT saturation measures in the ipsilateral hippocampus, paralleled by volume differences bilaterally. Disease duration correlated positively with iron content in the mesial temporal lobe, while seizure freedom was associated with a decrease of iron in the very same region. Our findings demonstrate the link between TLE clinical phenotype and brain anatomy beyond morphometry differences to show the impact of disease burden on specific tissue properties. We provide direct evidence for the differential effect of clinical phenotype characteristics on processes involving tissue myelin and iron in mesial temporal lobe structures. This study offers a proof-of-concept for the investigation of novel imaging biomarkers in focal epilepsy. |
|---|---|
| ISSN: | 18632661 18632653 |
| DOI: | 10.1007/s00429-021-02428-z |