A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise
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| Title: | A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise |
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| Authors: | Aditi Methi, Md Rezaul Islam, Lalit Kaurani, M Sadman Sakib, Dennis M. Krüger, Tonatiuh Pena, Susanne Burkhardt, David Liebetanz, André Fischer |
| Contributors: | Methi, Aditi, Islam, Md Rezaul, Kaurani, Lalit, Sakib, M Sadman, Krüger, Dennis M., Pena, Tonatiuh, Burkhardt, Susanne, Liebetanz, David, Fischer, André |
| Source: | Mol Neurobiol Molecular neurobiology 61(8), 5628-5645 (2024). doi:10.1007/s12035-023-03869-9 |
| Publisher Information: | Springer Science and Business Media LLC, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | Male, Volition, Neurogenesis, genetics [Transcriptome], Cognitive decline, metabolism [Hippocampus], Hippocampus, Article, Learning and memory, Single-cell RNAseq, Mice, physiology [Physical Conditioning, Animal], ddc:570, Physical Conditioning, Animal, Animals, Gene-expression, Dementia, Mice, Inbred C57BL [MeSH], Volition [MeSH], Environmental enrichment, Transcriptome/genetics [MeSH], Neurons/metabolism [MeSH], Animals [MeSH], Mice [MeSH], Male [MeSH], Physical Conditioning, Animal/physiology [MeSH], Single-Cell Analysis [MeSH], Signal Transduction [MeSH], Gene Expression Profiling [MeSH], Neurogenesis [MeSH], Aerobic exercise, Hippocampus/metabolism [MeSH], Neurons, Gene Expression Profiling, Mice, Inbred C57BL, metabolism [Neurons], Single-Cell Analysis, Transcriptome, Signal Transduction |
| Description: | Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for learning and memory. Previous research has demonstrated that exercise-mediated improvement of learning and memory in humans and rodents correlates with increased adult neurogenesis and processes related to enhanced synaptic plasticity. Nevertheless, the underlying molecular mechanisms are not fully understood. With the aim to further elucidate these mechanisms, we provide a comprehensive dataset of the mouse hippocampal transcriptome at the single-cell level after 4 weeks of voluntary wheel-running. Our analysis provides a number of interesting observations. For example, the results suggest that exercise affects adult neurogenesis by accelerating the maturation of a subpopulation of Prdm16-expressing neurons. Moreover, we uncover the existence of an intricate crosstalk among multiple vital signaling pathways such as NF-κB, Wnt/β-catenin, Notch, and retinoic acid (RA) pathways altered upon exercise in a specific cluster of excitatory neurons within the Cornu Ammonis (CA) region of the hippocampus. In conclusion, our study provides an important resource dataset and sheds further light on the molecular changes induced by exercise in the hippocampus. These findings have implications for developing targeted interventions aimed at optimizing cognitive health and preventing age-related cognitive decline. |
| Document Type: | Article Other literature type |
| Language: | English |
| ISSN: | 1559-1182 0893-7648 |
| DOI: | 10.1007/s12035-023-03869-9 |
| Access URL: | https://pubmed.ncbi.nlm.nih.gov/38217668 https://pub.dzne.de/record/270707 https://resolver.sub.uni-goettingen.de/purl?gro-2/140238 https://mbexc.uni-goettingen.de/literature/publications/900 https://sfb1286.uni-goettingen.de/literature/publications/251 https://repository.publisso.de/resource/frl:6492799 |
| Rights: | CC BY |
| Accession Number: | edsair.doi.dedup.....f06fb6b4340b6e5fa5af037c0d185c97 |
| Database: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for learning and memory. Previous research has demonstrated that exercise-mediated improvement of learning and memory in humans and rodents correlates with increased adult neurogenesis and processes related to enhanced synaptic plasticity. Nevertheless, the underlying molecular mechanisms are not fully understood. With the aim to further elucidate these mechanisms, we provide a comprehensive dataset of the mouse hippocampal transcriptome at the single-cell level after 4 weeks of voluntary wheel-running. Our analysis provides a number of interesting observations. For example, the results suggest that exercise affects adult neurogenesis by accelerating the maturation of a subpopulation of Prdm16-expressing neurons. Moreover, we uncover the existence of an intricate crosstalk among multiple vital signaling pathways such as NF-κB, Wnt/β-catenin, Notch, and retinoic acid (RA) pathways altered upon exercise in a specific cluster of excitatory neurons within the Cornu Ammonis (CA) region of the hippocampus. In conclusion, our study provides an important resource dataset and sheds further light on the molecular changes induced by exercise in the hippocampus. These findings have implications for developing targeted interventions aimed at optimizing cognitive health and preventing age-related cognitive decline. |
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| ISSN: | 15591182 08937648 |
| DOI: | 10.1007/s12035-023-03869-9 |