Impact of morbid obesity and bariatric surgery on antioxidant/oxidant balance of the unstimulated and stimulated human saliva
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| Názov: | Impact of morbid obesity and bariatric surgery on antioxidant/oxidant balance of the unstimulated and stimulated human saliva |
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| Autori: | Marek Niczyporuk, Małgorzata Knaś, Anna Zalewska, Hady Razak Hady, Katarzyna Sawicka, Mateusz Maciejczyk, Małgorzata Żendzian-Piotrowska, Danuta Waszkiel, Jerzy Robert Ładny, Jan Matczuk |
| Zdroj: | Journal of Oral Pathology & Medicine. 45:455-464 |
| Informácie o vydavateľovi: | Wiley, 2015. |
| Rok vydania: | 2015 |
| Predmety: | Adult, Glycation End Products, Advanced, Male, 0301 basic medicine, Catalase - metabolism, morbid - surgery, Glucation and products, Enzyme activation, Bariatric surgery - methods, Bariatric Surgery, Bariatric surgery - adverses effects, Saliva - metabolism, Antioxidants, Salivary Glands, 03 medical and health sciences, Oxidants - metabolism, Malondialdehyde, advanced - analysis, Humans, Malondialdehyde - metabolism, Obesity, Middle aged, Saliva, Salivary glands - metabolism, Peroxidase, 2. Zero hunger, 0303 health sciences, Superoxide Dismutase, morbid - metabolism, Polyphenols, Middle Aged, Catalase, Oxidants, Secretory rate, Antioxidants - metabolism, Obesity, Morbid, 3. Good health, Enzyme Activation, Oxidative Stress, Uric acid - metabolism, Female, Superoxide dismutase - metabolism, Peroxidase - metabolism, Polyphenols - metabolism, Secretory Rate, Oxidative stress - physiology |
| Popis: | ObjectiveThere is no study evaluating the influence of morbid obesity and bariatric surgery on antioxidant/oxidant homeostasis of the unstimulated and stimulated human saliva.Materials and MethodsSalivary flow rate, total antioxidant status (TAS), total oxidant status (TOS), oxidative status index (OSI), the total amount of uric acid (UA), polyphenols (pPh), catalase (CAT), superoxide dismutase 2 (SOD2), specific activity of peroxidase (Px), as well as malondialdehyde (MDA), and advanced glycation end products (AGE) concentrations were determined in the unstimulated (UWS) and stimulated (SWS) whole saliva of patients with morbid obesity before and after bariatric surgery.ResultsIn both UWS and SWS, the total amount of TOS, OSI, SOD2, and MDA was statistically higher in patients with morbid obesity as compared to the healthy controls, as well as significantly lower in the patients treated surgically as compared to the obese patients. The median values of the total amount of TAS, CAT, UA, pPh, and specific activity of Px were significantly reduced in UWS and SWS in patients with morbid obesity as compared to the control group and also statistically elevated in patients after bariatric surgery as compared to the patients with morbid obesity.ConclusionsIn morbid obesity, reduced unstimulated and stimulated salivary flow can be observed. Bariatric surgery restored only unstimulated salivary flow to normal values. Disturbances in oxidant/antioxidant homeostasis may be observed in UWS and SWS of obese patients before and after treatment. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1600-0714 0904-2512 |
| DOI: | 10.1111/jop.12383 |
| Prístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/26608886 https://pubmed.ncbi.nlm.nih.gov/26608886/ https://onlinelibrary.wiley.com/doi/10.1111/jop.12383 https://www.ncbi.nlm.nih.gov/pubmed/26608886 http://europepmc.org/abstract/MED/26608886 |
| Rights: | Wiley Online Library User Agreement |
| Prístupové číslo: | edsair.doi.dedup.....ef66042c82a359f33d559ccc1cddb838 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | ObjectiveThere is no study evaluating the influence of morbid obesity and bariatric surgery on antioxidant/oxidant homeostasis of the unstimulated and stimulated human saliva.Materials and MethodsSalivary flow rate, total antioxidant status (TAS), total oxidant status (TOS), oxidative status index (OSI), the total amount of uric acid (UA), polyphenols (pPh), catalase (CAT), superoxide dismutase 2 (SOD2), specific activity of peroxidase (Px), as well as malondialdehyde (MDA), and advanced glycation end products (AGE) concentrations were determined in the unstimulated (UWS) and stimulated (SWS) whole saliva of patients with morbid obesity before and after bariatric surgery.ResultsIn both UWS and SWS, the total amount of TOS, OSI, SOD2, and MDA was statistically higher in patients with morbid obesity as compared to the healthy controls, as well as significantly lower in the patients treated surgically as compared to the obese patients. The median values of the total amount of TAS, CAT, UA, pPh, and specific activity of Px were significantly reduced in UWS and SWS in patients with morbid obesity as compared to the control group and also statistically elevated in patients after bariatric surgery as compared to the patients with morbid obesity.ConclusionsIn morbid obesity, reduced unstimulated and stimulated salivary flow can be observed. Bariatric surgery restored only unstimulated salivary flow to normal values. Disturbances in oxidant/antioxidant homeostasis may be observed in UWS and SWS of obese patients before and after treatment. |
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| ISSN: | 16000714 09042512 |
| DOI: | 10.1111/jop.12383 |