Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders
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| Název: | Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders |
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| Autoři: | Radonjić, Nevena V., Hess, Jonathan L., Rovira, Paula, Andreassen, Ole A., Buitelaar, Jan, Ching, Christopher R. K., Franke, Barbara, Hoogman, Martine, Jahanshad, Neda, McDonald, Carrie, Schmaal, Lianne, Sisodiya, Sanjay M., Stein, Dan J., van den Heuvel, Odile A., van Erp, Theo G. M., van Rooij, Daan, Veltman, Dick J., Thompson, Paul, Faraone, Stephen V., Universitat Autònoma de Barcelona |
| Přispěvatelé: | Universitat Autònoma de Barcelona, Institut Català de la Salut, [Radonjić NV] Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY, USA. [Hess JL] Departments of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA. [Rovira P] Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Andreassen O] NORMENT—Institute of Clinical Medicine, Division of Mental Health and Addiction, Oslo University Hospital, University of Oslo, Oslo, Norway. [Buitelaar JK] Radboudumc, Radboud University Medical Center, Nijmegen, The Netherlands. Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Cognitive Neuroscience, Radboud. [Ching CRK] Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina Del Rey, CA, USA, Vall d'Hebron Barcelona Hospital Campus |
| Zdroj: | Mol Psychiatry Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Scientia Scientia. Dipòsit d'Informació Digital del Departament de Salut instname Radonjić, N V, Hess, J L, Rovira, P, Andreassen, O, Buitelaar, J K, Ching, C R K, Franke, B, Hoogman, M, Jahanshad, N, McDonald, C, Schmaal, L, Sisodiya, S M, Stein, D J, van den Heuvel, O A, van Erp, T G M, van Rooij, D, Veltman, D J, Thompson, P & Faraone, S V 2021, 'Structural brain imaging studies offer clues about the effects of the shared genetic etiology among neuropsychiatric disorders', Molecular Psychiatry, vol. 26, no. 6, pp. 2101-2110. https://doi.org/10.1038/s41380-020-01002-z Molecular Psychiatry, 26, 6, pp. 2101-2110 Molecular Psychiatry, vol 26, iss 6 Molecular Psychiatry |
| Publication Status: | Preprint |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2019. |
| Rok vydání: | 2019 |
| Témata: | Autism Spectrum Disorder, Autism, Biological Psychology, Clinical sciences, Diseases, Medical and Health Sciences, Clinical and health psychology, 0302 clinical medicine, 130 000 Cognitive Neurology & Memory, Otros calificadores::Otros calificadores::Otros calificadores::/genética, Psychology, 2.1 Biological and endogenous factors, Aetiology, ANATOMÍA::sistema nervioso::sistema nervioso central::encéfalo, 10. No inequality, Psychiatry, Otros calificadores::Otros calificadores::Otros calificadores::/diagnóstico por imagen, Other subheadings::Other subheadings::Other subheadings::/diagnostic imaging, Brain, Biological Sciences, Psychiatry - Radboud University Medical Center, Serious Mental Illness, ANATOMY::Nervous System::Central Nervous System::Brain, 3. Good health, Mental Health, Mental health, Other subheadings::Other subheadings::Other subheadings::/genetics, Intellectual and Developmental Disabilities (IDD), Neuroimaging, Malalties mentals - Aspectes genètics, Article, 03 medical and health sciences, Clinical Research, Genetics, Humans, Depressive Disorder, Depressive Disorder, Major, Biomedical and Clinical Sciences, Radboudumc 7: Neurodevelopmental disorders DCMN: Donders Center for Medical Neuroscience, Prevention, Psychology and Cognitive Sciences, Neurosciences, Major, Cervell - Imatgeria, PSIQUIATRÍA Y PSICOLOGÍA::trastornos mentales, Brain Disorders, Attention Deficit Disorder with Hyperactivity, Schizophrenia, Biological psychology, PSYCHIATRY AND PSYCHOLOGY::Mental Disorders |
| Popis: | Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, we acquired standardized mean differences (SMDs) in regional brain volume and cortical thickness between cases and controls. We had data on 41 brain regions for: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), epilepsy, major depressive disorder (MDD), obsessive compulsive disorder (OCD), and schizophrenia (SCZ). These data had been derived from 24,360 patients and 37,425 controls. The SMDs were significantly correlated between SCZ and BD, OCD, MDD, and ASD. MDD was positively correlated with BD and OCD. BD was positively correlated with OCD and negatively correlated with ADHD. These pairwise correlations among disorders were correlated with the corresponding pairwise correlations among disorders derived from genomewide association studies (r = 0.494). Our results show substantial similarities in sMRI phenotypes among neuropsychiatric disorders and suggest that these similarities are accounted for, in part, by corresponding similarities in common genetic variant architectures. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/s41380-020-01002-z |
| DOI: | 10.1101/809582 |
| Přístupová URL adresa: | https://www.nature.com/articles/s41380-020-01002-z.pdf https://europepmc.org/articles/pmc8440178?pdf=render https://pubmed.ncbi.nlm.nih.gov/33456050 https://ddd.uab.cat/record/249654 https://hdl.handle.net/11351/6875 https://minerva-access.unimelb.edu.au/bitstream/11343/274233/1/s41380-020-01002-z.pdf https://research.vumc.nl/en/publications/structural-brain-imaging-studies-offer-clues-about-the-effects-of https://pubmed.ncbi.nlm.nih.gov/33456050/ https://www.narcis.nl/publication/RecordID/oai%3Apure.atira.dk%3Apublications%2Fd703dc9c-cd63-4654-9ef0-330f8f1c9f2d https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8440178 https://www.nature.com/articles/s41380-020-01002-z.pdf https://www.biorxiv.org/content/biorxiv/early/2019/10/17/809582.full.pdf https://www.biorxiv.org/content/10.1101/809582v3 https://research.vumc.nl/en/publications/d703dc9c-cd63-4654-9ef0-330f8f1c9f2d https://pure.amsterdamumc.nl/en/publications/4a2ac594-206b-4048-b9f6-6382774d059b https://doi.org/10.1038/s41380-020-01002-z https://hdl.handle.net/2066/237842 https://repository.ubn.ru.nl//bitstream/handle/2066/237842/237842.pdf https://discovery-pp.ucl.ac.uk/id/eprint/10119928/ https://escholarship.org/uc/item/3f88f82v https://escholarship.org/content/qt3f88f82v/qt3f88f82v.pdf |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . |
| Přístupové číslo: | edsair.doi.dedup.....eec60bb55243ba812bcecc7d1cfdfff2 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Genomewide association studies have found significant genetic correlations among many neuropsychiatric disorders. In contrast, we know much less about the degree to which structural brain alterations are similar among disorders and, if so, the degree to which such similarities have a genetic etiology. From the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, we acquired standardized mean differences (SMDs) in regional brain volume and cortical thickness between cases and controls. We had data on 41 brain regions for: attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BD), epilepsy, major depressive disorder (MDD), obsessive compulsive disorder (OCD), and schizophrenia (SCZ). These data had been derived from 24,360 patients and 37,425 controls. The SMDs were significantly correlated between SCZ and BD, OCD, MDD, and ASD. MDD was positively correlated with BD and OCD. BD was positively correlated with OCD and negatively correlated with ADHD. These pairwise correlations among disorders were correlated with the corresponding pairwise correlations among disorders derived from genomewide association studies (r = 0.494). Our results show substantial similarities in sMRI phenotypes among neuropsychiatric disorders and suggest that these similarities are accounted for, in part, by corresponding similarities in common genetic variant architectures. |
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| ISSN: | 14765578 13594184 |
| DOI: | 10.1038/s41380-020-01002-z |