Ureter Myogenesis: Putting Teashirt into Context
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| Titel: | Ureter Myogenesis: Putting Teashirt into Context |
|---|---|
| Autoren: | C. M., Lye, Fasano, L., Woolf, A. S. |
| Weitere Verfasser: | CONTENSIN, Magali |
| Quelle: | Lye, C M, Fasano, L & Woolf, A S 2010, 'Ureter myogenesis: Putting teashirt into context', Journal of the American Society of Nephrology, vol. 21, no. 1, pp. 24-30. https://doi.org/10.1681/ASN.2008111206 |
| Verlagsinformationen: | Ovid Technologies (Wolters Kluwer Health), 2010. |
| Publikationsjahr: | 2010 |
| Schlagwörter: | 0301 basic medicine, Smooth/*physiology, Knockout, Hydronephrosis, Muscle Development, Mice, 03 medical and health sciences, Ureteral Obstruction/physiopathology, Drosophila Proteins/physiology, Animals, Drosophila Proteins, Humans, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Muscle Development/*physiology, Mice, Knockout, 0303 health sciences, Transcription Factors/genetics/physiology, Ureter/*physiology, Animal, Hydronephrosis/physiopathology, Muscle, Smooth, Repressor Proteins, Disease Models, Animal, Knockou, Disease Models, Muscle, Drosophila, Ureter, Repressor Proteins/physiology, Transcription Factors, Ureteral Obstruction |
| Beschreibung: | After the basic shape of the mammalian ureter is established, its epithelia mature and a coat of smooth muscle cells differentiate around nascent urothelia. The ureter actively propels tubular fluid from the renal pelvis to the bladder, and this peristalsis, which starts in the fetal period, requires coordinated smooth muscle contraction. Teashirt-3 (Tshz3) is expressed in smooth muscle cell precursors that form the wall of the forming mammalian ureter. The Teashirt gene family was first identified in Drosophila where Teashirt (Tsh) protein acts as a transcription factor directing embryonic anterior-posterior patterning and leg and eye development. In fly embryonic renal tubules, Tsh is expressed in mesodermally derived stellate cells intercalating between principal cells, and a paralogue, tiptop, is expressed in forming tubules. Teashirt is a component of several gene networks in flies and it is notable that similar networks control mammalian renal tract development. Null mutation of Tshz3 in mice leads to failure of functional muscularization in the top of the ureter and this is followed by congenital hydronephrosis. A signaling pathway can be envisaged, starting with sonic hedgehog secreted by the nascent ureteric urothelium and ending with ureteric smooth muscle cell differentiation, with Tshz3 downstream of bone morphogenetic protein 4 and upstream of myocardin and smooth muscle cell contractile protein synthesis. The phenotype of Tshz3 mutant mice resembles that of human congenital pelviureteric junction obstruction, and we suggest these individuals may have mutations of genes encoding molecules in the differentiation pathway mediated by Tshz3. |
| Publikationsart: | Article |
| Sprache: | English |
| ISSN: | 1046-6673 |
| DOI: | 10.1681/asn.2008111206 |
| Zugangs-URL: | https://jasn.asnjournals.org/content/21/1/24.full.pdf https://pubmed.ncbi.nlm.nih.gov/19926888 https://hal.science/hal-00506100v1 https://doi.org/10.1681/asn.2008111206 https://research.manchester.ac.uk/en/publications/3ec8429e-3063-4d3a-a63c-b0969a5760ef https://doi.org/10.1681/ASN.2008111206 https://pubmed.ncbi.nlm.nih.gov/19926888/ https://europepmc.org/article/MED/19926888 https://www.ncbi.nlm.nih.gov/pubmed/19926888 https://jasn.asnjournals.org/content/21/1/24.short https://jasn.asnjournals.org/lookup/doi/10.1681/ASN.2008111206 https://www.research.manchester.ac.uk/portal/en/publications/ureter-myogenesis-putting-teashirt-into-context(3ec8429e-3063-4d3a-a63c-b0969a5760ef).html http://jasn.asnjournals.org/cgi/reprint/21/1/24 https://research.manchester.ac.uk/en/publications/3ec8429e-3063-4d3a-a63c-b0969a5760ef https://doi.org/10.1681/ASN.2008111206 |
| Dokumentencode: | edsair.doi.dedup.....ee9fdaa6aa9f4505f44c41c1fb89cf0c |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | After the basic shape of the mammalian ureter is established, its epithelia mature and a coat of smooth muscle cells differentiate around nascent urothelia. The ureter actively propels tubular fluid from the renal pelvis to the bladder, and this peristalsis, which starts in the fetal period, requires coordinated smooth muscle contraction. Teashirt-3 (Tshz3) is expressed in smooth muscle cell precursors that form the wall of the forming mammalian ureter. The Teashirt gene family was first identified in Drosophila where Teashirt (Tsh) protein acts as a transcription factor directing embryonic anterior-posterior patterning and leg and eye development. In fly embryonic renal tubules, Tsh is expressed in mesodermally derived stellate cells intercalating between principal cells, and a paralogue, tiptop, is expressed in forming tubules. Teashirt is a component of several gene networks in flies and it is notable that similar networks control mammalian renal tract development. Null mutation of Tshz3 in mice leads to failure of functional muscularization in the top of the ureter and this is followed by congenital hydronephrosis. A signaling pathway can be envisaged, starting with sonic hedgehog secreted by the nascent ureteric urothelium and ending with ureteric smooth muscle cell differentiation, with Tshz3 downstream of bone morphogenetic protein 4 and upstream of myocardin and smooth muscle cell contractile protein synthesis. The phenotype of Tshz3 mutant mice resembles that of human congenital pelviureteric junction obstruction, and we suggest these individuals may have mutations of genes encoding molecules in the differentiation pathway mediated by Tshz3. |
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| ISSN: | 10466673 |
| DOI: | 10.1681/asn.2008111206 |