Controlled attenuation parameter value and the risk of hepatocellular carcinoma in chronic hepatitis B patients under antiviral therapy
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| Název: | Controlled attenuation parameter value and the risk of hepatocellular carcinoma in chronic hepatitis B patients under antiviral therapy |
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| Autoři: | Joo Hyun Oh, Hye Won Lee, Dong Hyun Sinn, Jun Yong Park, Beom Kyung Kim, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Wonseok Kang, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Yong-Han Paik |
| Přispěvatelé: | Joo Hyun Oh, Hye Won Lee, Dong Hyun Sinn, Jun Yong Park, Beom Kyung Kim, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Wonseok Kang, Geum-Youn Gwak, Moon Seok Choi, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Yong-Han Paik, Kim, Do Young |
| Zdroj: | Hepatology International. 15:892-900 |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2021. |
| Rok vydání: | 2021 |
| Témata: | Liver Cirrhosis, 0301 basic medicine, Hepatitis B virus, Hepatocellular* / drug therapy, Transient elastography, Carcinoma, Hepatocellular, Hepatocellular carcinoma, Antiviral Agents / therapeutic use, Liver Cirrhosis / drug therapy, Liver Neoplasms* / drug therapy, Chronic hepatitis B, Antiviral Agents, 03 medical and health sciences, Hepatitis B, Chronic, Risk Factors, Humans, Liver Neoplasms* / epidemiology, 0303 health sciences, Liver Neoplasms* / etiology, Carcinoma, Liver Neoplasms, Chronic* / complications, Hepatitis B, Hepatocellular* / etiology, 3. Good health, Hepatocellular* / epidemiology, Chronic* / drug therapy, Controlled attenuation parameter, Elasticity Imaging Techniques |
| Popis: | Controlled attenuation parameter (CAP) can evaluate hepatic steatosis in patients with chronic hepatitis B (CHB). However, prognostic implications of CAP value remain unclear. We evaluated the association between CAP and the risk of hepatocellular carcinoma (HCC) in patients with CHB under antiviral therapy and maintained virologic response.A total of 1823 CHB patients who were taking nucleos(t)ide analogue and showing suppressed hepatitis B virus replication were analyzed. The primary outcome was incident HCC during follow-up. Patients were grouped into those with and without advanced chronic liver disease (ACLD) (liver stiffness measurement cutoff: 10 kPa), and those with and without hepatic steatosis (CAP cutoff: 222 dB/m).During 6.4 years of follow-up, 127 patients (7.0%) newly developed HCC. Among patients with ACLD (n = 382), the cumulative HCC incidence rate was lower for those with CAP ≥ 222 (11.0% at 5 years) than those with CAP |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 1936-0541 1936-0533 |
| DOI: | 10.1007/s12072-021-10205-7 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/34260013 https://pubmed.ncbi.nlm.nih.gov/34260013/ https://link.springer.com/article/10.1007/s12072-021-10205-7 https://europepmc.org/article/MED/34260013 https://www.ncbi.nlm.nih.gov/pubmed/34260013 |
| Rights: | Springer TDM CC BY NC ND |
| Přístupové číslo: | edsair.doi.dedup.....ee7aa4b5995085366ba9a524d705f96f |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Controlled attenuation parameter (CAP) can evaluate hepatic steatosis in patients with chronic hepatitis B (CHB). However, prognostic implications of CAP value remain unclear. We evaluated the association between CAP and the risk of hepatocellular carcinoma (HCC) in patients with CHB under antiviral therapy and maintained virologic response.A total of 1823 CHB patients who were taking nucleos(t)ide analogue and showing suppressed hepatitis B virus replication were analyzed. The primary outcome was incident HCC during follow-up. Patients were grouped into those with and without advanced chronic liver disease (ACLD) (liver stiffness measurement cutoff: 10 kPa), and those with and without hepatic steatosis (CAP cutoff: 222 dB/m).During 6.4 years of follow-up, 127 patients (7.0%) newly developed HCC. Among patients with ACLD (n = 382), the cumulative HCC incidence rate was lower for those with CAP ≥ 222 (11.0% at 5 years) than those with CAP |
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| ISSN: | 19360541 19360533 |
| DOI: | 10.1007/s12072-021-10205-7 |