Infrared Evanescent Wave Planar Fiber Sensor for the Detection of Lysine in Pharmaceuticals
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| Název: | Infrared Evanescent Wave Planar Fiber Sensor for the Detection of Lysine in Pharmaceuticals |
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| Autoři: | Yang, Jianqing, Zhao, Yongkun, Wu, Zeyan, Guo, Haitao, Xu, Yantao, Yang, Minghong, Lian, Zhenggang, Zhang, Xianghua, Xu, Yinsheng |
| Přispěvatelé: | Jonchère, Laurent |
| Zdroj: | Journal of Lightwave Technology. 43:6932-6938 |
| Informace o vydavateli: | Institute of Electrical and Electronics Engineers (IEEE), 2025. |
| Rok vydání: | 2025 |
| Témata: | Composite material, Optical fiber, Bending, Biochemistry, Absorption, Engineering, Sensitivity, Optical fibers, Fiber, Optoelectronics, [CHIM.MATE] Chemical Sciences/Material chemistry, Electronic engineering, Computer graphics (images), Lysine, Physics, Optical fiber sensors, Drugs, Optics, Fiber optic sensor, Acoustics, Computer science, Materials science, Wave energy conversion, Amino acid, Optical surface waves, Chemistry, Optical fiber testing, Evanescent wave, Planar, Glass, Infrared |
| Popis: | Lysine, an essential amino acid that cannot be synthesized by the human body, is often supplemented through medication intake to maintain health and prevent diseases, highlighting the critical importance of detecting lysine-containing drugs. In this work, we proposed a novel method for lysine detection utilizing an infrared optical fiber sensor. A curved planar optical fiber sensor (H = 117 μm, L = 26 mm, R = 0.7 mm) was fabricated through hot-press moulding, thermal drawing, and bending processes. This sensor exhibits a sensitivity of 0.04 (a.u./(mg·mL−1)) and a detection limit of 2.25 mg/mL for lysine solutions. Analysis of commercially available drugs demonstrates that this infrared optical fiber sensor achieves high accuracy in both qualitative and quantitative drug analysis, making it suitable for extensive application in quality control and random inspections during pharmaceutical production processes. |
| Druh dokumentu: | Article |
| ISSN: | 1558-2213 0733-8724 |
| DOI: | 10.1109/jlt.2025.3563953 |
| Přístupová URL adresa: | https://hal.science/hal-05229959v1 https://doi.org/10.1109/jlt.2025.3563953 |
| Rights: | IEEE Copyright |
| Přístupové číslo: | edsair.doi.dedup.....edcbe5a862b8f7717ed8185a9607ff95 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Lysine, an essential amino acid that cannot be synthesized by the human body, is often supplemented through medication intake to maintain health and prevent diseases, highlighting the critical importance of detecting lysine-containing drugs. In this work, we proposed a novel method for lysine detection utilizing an infrared optical fiber sensor. A curved planar optical fiber sensor (H = 117 μm, L = 26 mm, R = 0.7 mm) was fabricated through hot-press moulding, thermal drawing, and bending processes. This sensor exhibits a sensitivity of 0.04 (a.u./(mg·mL−1)) and a detection limit of 2.25 mg/mL for lysine solutions. Analysis of commercially available drugs demonstrates that this infrared optical fiber sensor achieves high accuracy in both qualitative and quantitative drug analysis, making it suitable for extensive application in quality control and random inspections during pharmaceutical production processes. |
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| ISSN: | 15582213 07338724 |
| DOI: | 10.1109/jlt.2025.3563953 |