Effect of sulfite on cognitive function in normal and sulfite oxidase deficient rats
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| Název: | Effect of sulfite on cognitive function in normal and sulfite oxidase deficient rats |
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| Autoři: | Savcioglu, F., Hacioglu, G., Yargiçoglu, P., Agar, A., Küçükatay, Vural. |
| Zdroj: | Neurotoxicology and Teratology. 27:47-54 |
| Informace o vydavateli: | Elsevier BV, 2005. |
| Rok vydání: | 2005 |
| Témata: | cognition, Male, 0301 basic medicine, Time Factors, hippocampus, avoidance behavior, alpha tocopherol, Hippocampus, Antioxidants, Random Allocation, sulfite, Cognition, oxidative stress, Vitamin E, rat, Drug Interactions, Oxidoreductases Acting on Sulfur Group Donors, 0303 health sciences, Behavior, Animal, article, lipid peroxidation, Food additives, enzyme activity, 3. Good health, priority journal, Liver, motor performance, enzyme deficiency, nerve cell, thiobarbituric acid reactive substance, animal experiment, Motor Activity, Thiobarbituric Acid Reactive Substances, animal tissue, learning disorder, 03 medical and health sciences, sulfite oxidase, male, Animals, Antioxidants/pharmacology, Avoidance Learning/drug effects, Behavior, Animal/drug effects, Cognition/*drug effects, Cysteine/*analogs & derivatives/blood, Hippocampus/drug effects/metabolism, Liver/drug effects/metabolism, Motor Activity/drug effects, Oxidoreductases Acting on Sulfur Group Donors/*deficiency/metabolism, Rats, Sulfites/*toxicity, Thiobarbituric Acid Reactive Substances/*metabolism, Vitamin E/pharmacology, Avoidance Learning, Sulfites, controlled study, Cysteine, Behavior, nonhuman, Animal, toxicity, Oxidative stress, Sulfite, Rat, protein determination |
| Popis: | Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring active avoidance learning in normal and SOX-deficient rats. For this purpose, male albino rats used in this study were divided into eight groups such as control group (C), sulfite group (25 mg/kg) (S), vitamin E group (50 mg/kg) (E), sulfite (25 mg/kg)+vitamin E group (50 mg/kg) (SE), SOX-deficient group (D), deficient+vitamin E group (50 mg/kg) (DE), deficient+sulfite group (25 mg/kg) (DS) and deficient+sulfite (25 mg/kg)+vitamin E group (50 mg/kg) (DSE). Sulfite-induced impairment of active avoidance learning in SOX-deficient rats but not in normal rats. Sulfite had no effect on hippocampus TBARS levels in SOX normal groups. In SOX-deficient rats, TBARS levels were found to be significantly increased with sulfite exposure. Vitamin E reversed the observed detrimental effects of sulfite in the SOX-deficient rats on their hippocampal TBARS but not on their active avoidance learning. In conclusion, sulfite has neurotoxic effects in sulfite oxidase deficient rats, but this effect may not depend on oxidative stress. |
| Druh dokumentu: | Article |
| Jazyk: | English |
| ISSN: | 0892-0362 |
| DOI: | 10.1016/j.ntt.2004.10.002 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/15681120 http://europepmc.org/abstract/MED/15681120 https://www.sciencedirect.com/science/article/pii/S0892036204001436 http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4980 |
| Rights: | Elsevier TDM |
| Přístupové číslo: | edsair.doi.dedup.....eda36c40a0fb6d0ee768eabc5e2d34bc |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring active avoidance learning in normal and SOX-deficient rats. For this purpose, male albino rats used in this study were divided into eight groups such as control group (C), sulfite group (25 mg/kg) (S), vitamin E group (50 mg/kg) (E), sulfite (25 mg/kg)+vitamin E group (50 mg/kg) (SE), SOX-deficient group (D), deficient+vitamin E group (50 mg/kg) (DE), deficient+sulfite group (25 mg/kg) (DS) and deficient+sulfite (25 mg/kg)+vitamin E group (50 mg/kg) (DSE). Sulfite-induced impairment of active avoidance learning in SOX-deficient rats but not in normal rats. Sulfite had no effect on hippocampus TBARS levels in SOX normal groups. In SOX-deficient rats, TBARS levels were found to be significantly increased with sulfite exposure. Vitamin E reversed the observed detrimental effects of sulfite in the SOX-deficient rats on their hippocampal TBARS but not on their active avoidance learning. In conclusion, sulfite has neurotoxic effects in sulfite oxidase deficient rats, but this effect may not depend on oxidative stress. |
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| ISSN: | 08920362 |
| DOI: | 10.1016/j.ntt.2004.10.002 |