Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion
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| Název: | Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion |
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| Autoři: | Bianca Cioni, Anniek Zaalberg, Judy R. van Beijnum, Monique H. M. Melis, Johan van Burgsteden, Mauro J. Muraro, Erik Hooijberg, Dennis Peters, Ingrid Hofland, Yoni Lubeck, Jeroen de Jong, Joyce Sanders, Judith Vivié, Henk G. van der Poel, Jan Paul de Boer, Arjan W. Griffioen, Wilbert Zwart, Andries M. Bergman |
| Přispěvatelé: | Hubrecht Institute with UMC |
| Zdroj: | Nat Commun Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020) Cioni, B, Zaalberg, A, van Beijnum, J R, Melis, M H M, van Burgsteden, J, Muraro, M J, Hooijberg, E, Peters, D, Hofland, I, Lubeck, Y, de Jong, J, Sanders, J, Vivié, J, van der Poel, H G, de Boer, J P, Griffioen, A W, Zwart, W & Bergman, A M 2020, 'Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion', Nature Communications, vol. 11, no. 1, 4498, pp. 4498. https://doi.org/10.1038/s41467-020-18313-y |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2020. |
| Rok vydání: | 2020 |
| Témata: | Male, 0301 basic medicine, Prostate/pathology, Triggering Receptor Expressed on Myeloid Cells-1/metabolism, Neoplasm Invasiveness/immunology, Tosyl Compounds/pharmacology, THP-1 Cells, Science, Biopsy, Receptors, Androgen/metabolism, Cell Movement/drug effects, Macrophages/immunology, SDG 3 – Goede gezondheid en welzijn, Prostatic Neoplasms/immunology, Article, Disease-Free Survival, 03 medical and health sciences, Robotic Surgical Procedures, SDG 3 - Good Health and Well-being, Cell Movement, Cell Line, Tumor, Nitriles, Journal Article, Humans, Anilides, Neoplasm Invasiveness, Aged, Prostatectomy, 0303 health sciences, Signal Transduction/immunology, Research Support, Non-U.S. Gov't, Macrophages, Prostate, Androgen Antagonists, Middle Aged, Blood Buffy Coat/cytology, Coculture Techniques, Neoadjuvant Therapy, Progression-Free Survival, Anilides/pharmacology, 3. Good health, Chemotherapy, Adjuvant, Case-Control Studies, Nitriles/pharmacology, Blood Buffy Coat, Single-Cell Analysis, Androgen Antagonists/pharmacology |
| Popis: | The androgen receptor (AR) is the master regulator of prostate cancer (PCa) development, and inhibition of AR signalling is the most effective PCa treatment. AR is expressed in PCa cells and also in the PCa-associated stroma, including infiltrating macrophages. Macrophages have a decisive function in PCa initiation and progression, but the role of AR in macrophages remains largely unexplored. Here, we show that AR signalling in the macrophage-like THP-1 cell line supports PCa cell line migration and invasion in culture via increased Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) signalling and expression of its downstream cytokines. Moreover, AR signalling in THP-1 and monocyte-derived macrophages upregulates IL-10 and markers of tissue residency. In conclusion, our data suggest that AR signalling in macrophages may support PCa invasiveness, and blocking this process may constitute one mechanism of anti-androgen therapy. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-18313-y |
| Přístupová URL adresa: | https://www.nature.com/articles/s41467-020-18313-y.pdf https://pubmed.ncbi.nlm.nih.gov/32908142 https://doaj.org/article/3be95a4024404f56acd7fe8a4155f96c https://www.narcis.nl/publication/RecordID/oai%3Apure.tue.nl%3Apublications%2Fe82c404f-a6c4-4f89-8619-d6170a4589c0 https://www.ncbi.nlm.nih.gov/pubmed/32908142 https://www.nature.com/articles/s41467-020-18313-y https://research.vumc.nl/en/publications/androgen-receptor-signalling-in-macrophages-promotes-trem-1-media https://pubmed.ncbi.nlm.nih.gov/32908142/ https://research.tue.nl/nl/publications/androgen-receptor-signalling-in-macrophages-promotes-trem-1-media https://research.vumc.nl/en/publications/442a9c5a-96f4-4acc-84bf-d17a819ef7a8 https://dspace.library.uu.nl/handle/1874/440661 https://hdl.handle.net/1887/3627624 |
| Rights: | CC BY taverne |
| Přístupové číslo: | edsair.doi.dedup.....eb7992137e6362d104fb4e2fda68436a |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | The androgen receptor (AR) is the master regulator of prostate cancer (PCa) development, and inhibition of AR signalling is the most effective PCa treatment. AR is expressed in PCa cells and also in the PCa-associated stroma, including infiltrating macrophages. Macrophages have a decisive function in PCa initiation and progression, but the role of AR in macrophages remains largely unexplored. Here, we show that AR signalling in the macrophage-like THP-1 cell line supports PCa cell line migration and invasion in culture via increased Triggering Receptor Expressed on Myeloid cells-1 (TREM-1) signalling and expression of its downstream cytokines. Moreover, AR signalling in THP-1 and monocyte-derived macrophages upregulates IL-10 and markers of tissue residency. In conclusion, our data suggest that AR signalling in macrophages may support PCa invasiveness, and blocking this process may constitute one mechanism of anti-androgen therapy. |
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| ISSN: | 20411723 |
| DOI: | 10.1038/s41467-020-18313-y |