Per Anhalter ins Axon: Neuronale Mitochondrien transportieren mRNA
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| Název: | Per Anhalter ins Axon: Neuronale Mitochondrien transportieren mRNA |
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| Autoři: | Alina Rühmkorf, Angelika B. Harbauer |
| Zdroj: | BIOspektrum. 29:375-377 |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2023. |
| Rok vydání: | 2023 |
| Témata: | 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Wissenschaft Special, Life Sciences, general, Biochemistry, general, Human Genetics, Microbiology, Pharmacology/Toxicology, ddc |
| Popis: | Local translation of mRNAs supports the survival and identity of the axonal and dendritic neuronal sub-compartments. Interestingly, one of the largest categories of locally synthesized proteins are mitochondrial proteins. Recent advances have shown that axonal RNA transport is linked to the transport of several organelles. Here, we describe how mitochondrial hitch-hiking provides an elegant solution to transport mRNAs into the axon to sustain local mitochondrial homeostasis. |
| Druh dokumentu: | Article |
| Popis souboru: | application/pdf |
| Jazyk: | German |
| ISSN: | 1868-6249 0947-0867 |
| DOI: | 10.1007/s12268-023-1954-3 |
| Přístupová URL adresa: | https://mediatum.ub.tum.de/1761583 |
| Rights: | CC BY |
| Přístupové číslo: | edsair.doi.dedup.....eb7311e5883035e2d6bd4454469eb03d |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Local translation of mRNAs supports the survival and identity of the axonal and dendritic neuronal sub-compartments. Interestingly, one of the largest categories of locally synthesized proteins are mitochondrial proteins. Recent advances have shown that axonal RNA transport is linked to the transport of several organelles. Here, we describe how mitochondrial hitch-hiking provides an elegant solution to transport mRNAs into the axon to sustain local mitochondrial homeostasis. |
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| ISSN: | 18686249 09470867 |
| DOI: | 10.1007/s12268-023-1954-3 |