View in EDS

Coexistence of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: Case Report and Review of the Literature

Saved in:
Bibliographic Details
Title: Coexistence of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease: Case Report and Review of the Literature
Authors: Verde, Federico, Aiello, Edoardo Nicolò, Adobbati, Laura, Poletti, Barbara, Solca, Federica, Tiloca, Cinzia, Sangalli, Davide, Maranzano, Alessio, Muscio, Cristina, Ratti, Antonia, Zago, Stefano, Ticozzi, Nicola, Frisoni, Giovanni Battista, Silani, Vincenzo
Source: Journal of Alzheimer's Disease. 95:1383-1399
Publisher Information: SAGE Publications, 2023.
Publication Year: 2023
Subject Terms: Male, Frontotemporal Dementia / genetics, Amyotrophic Lateral Sclerosis / genetics, Alzheimer Disease / diagnosis, Frontotemporal Dementia / complications, Brain / diagnostic imaging, Amyotrophic lateral sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis, neurodegeneration, neuropsychology, 3. Good health, Amyotrophic Lateral Sclerosis / complications, 618.97, Cognitive Dysfunction / complications, Neuropsychology, Humans, Female, Neurodegeneration, Amyotrophic Lateral Sclerosis / diagnosis, Alzheimer Disease / diagnostic imaging, Frontotemporal Dementia / diagnostic imaging
Description: We describe a case of amyotrophic lateral sclerosis (ALS) associated with Alzheimer’s disease (AD) and review the literature about the coexistence of the two entities, highlighting the following: mean age at onset is 63.8 years, with slight female predominance; ALS tends to manifest after cognitive impairment and often begins in the bulbar region; average disease duration is 3 years; cognitive phenotype is mostly amnestic; the pattern of brain involvement is, in most cases, consistent with AD. Our case and the reviewed ones suggest that patients with ALS and dementia lacking unequivocal features of FTD should undergo additional examinations in order to recognize AD.
Document Type: Article
File Description: application/pdf
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-230562
Access URL: https://hdl.handle.net/2434/1032037
https://doi.org/10.3233/jad-230562
https://hdl.handle.net/10281/520836
https://doi.org/10.3233/JAD-230562
https://archive-ouverte.unige.ch/unige:177099
https://doi.org/10.3233/jad-230562
Accession Number: edsair.doi.dedup.....e8ff4268153eebd8505927d1e13450f3
Database: OpenAIRE
Description
Abstract:We describe a case of amyotrophic lateral sclerosis (ALS) associated with Alzheimer’s disease (AD) and review the literature about the coexistence of the two entities, highlighting the following: mean age at onset is 63.8 years, with slight female predominance; ALS tends to manifest after cognitive impairment and often begins in the bulbar region; average disease duration is 3 years; cognitive phenotype is mostly amnestic; the pattern of brain involvement is, in most cases, consistent with AD. Our case and the reviewed ones suggest that patients with ALS and dementia lacking unequivocal features of FTD should undergo additional examinations in order to recognize AD.
ISSN:18758908
13872877
DOI:10.3233/jad-230562