Daytime sleepiness and BMI exhibit gender and age differences in patients with central disorders of hypersomnolence
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| Titel: | Daytime sleepiness and BMI exhibit gender and age differences in patients with central disorders of hypersomnolence |
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| Autoren: | Laura Ferrazzini, Markus Schmidt, Zhongxing Zhang, Ramin Khatami, Yves Dauvilliers, Lucie Barateau, Geert Mayer, Fabio Pizza, Giuseppe Plazzi, Jari K. Gool, Rolf Fronczek, Gert Jan Lammers, Rafael del Rio‐Villegas, Rosa Peraita‐Adrados, Markku Partinen, Sebastiaan Overeem, Karel Sonka, Joan Santamaria, Raphael Heinzer, Francesca Canellas, Antonio Martins da Silva, Birgit Högl, Christian Veauthier, Aleksandra Wierzbicka, Eva Feketeova, Jitka Buskova, Michel Lecendreux, Silvia Miano, Ulf Kallweit, Anna Heidbreder, Claudio L. A. Bassetti, Julia van der Meer |
| Weitere Verfasser: | Department of Neurosciences, Clinicum, HUS Neurocenter, University of Helsinki |
| Quelle: | J Sleep Res Docusalut Conselleria de Salut i Consum del Govern de les Illes Balears Journal of sleep research, vol. 34, no. 3, pp. e14365 |
| Verlagsinformationen: | Wiley, 2024. |
| Publikationsjahr: | 2024 |
| Schlagwörter: | excessive daytime sleepiness, hypersomnia, impulsive eating behaviour, obesity, sex, Sleep and Neurology, Neurosciences, Humans, Female, Male, Adult, Body Mass Index, Disorders of Excessive Somnolence/physiopathology, Disorders of Excessive Somnolence/epidemiology, Narcolepsy/physiopathology, Sex Factors, Middle Aged, Age Factors, Young Adult, Feeding Behavior, Adolescent, Body Weight, Neurology and psychiatry |
| Beschreibung: | SummaryThe aim of the present study was to examine gender and age‐specific effects on subjective daytime sleepiness (as measured by the Epworth Sleepiness Scale), body weight and eating behaviour in patients with central disorders of hypersomnolence. Based on the European Narcolepsy Network database, we compared 1035 patients with narcolepsy type I and 505 patients with other central disorders of hypersomnolence (“narcoleptic borderland”), including narcolepsy type II (N = 308) and idiopathic hypersomnia (N = 174), using logistic regression and general linear models. In the entire study population, the Epworth Sleepiness Scale was higher in women (N = 735, mean age = 30 years, mean Epworth Sleepiness Scale = 16.6 ± SD 3.9) than in men (N = 805, mean age = 32 years, mean Epworth Sleepiness Scale = 15.8 ± SD 4.4). In women with narcolepsy type I (N = 475), both Epworth Sleepiness Scale and body mass index increased in parallel with age. In women of the narcoleptic borderland (N = 260), the Epworth Sleepiness Scale markedly peaked in their early 30s, while body mass index only started to rise at that age. This rise in body mass index following the Epworth Sleepiness Scale peak cannot be explained by sleepiness‐induced uncontrolled eating, as self‐reported uncontrolled eating was negatively associated with the Epworth Sleepiness Scale in this group. We propose that the narcoleptic borderland harbours a unique cluster of women in their fertile years with an unexplored aetiology requiring further investigation towards tailored interventions. |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/pdf; application/zip |
| Sprache: | English |
| ISSN: | 1365-2869 0962-1105 |
| DOI: | 10.1111/jsr.14365 |
| DOI: | 10.48620/76440 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/39428908 https://hdl.handle.net/20.500.13003/21333 https://hdl.handle.net/20.500.13003/25102 https://hdl.handle.net/1887/4209531 http://hdl.handle.net/10138/587699 http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_74465E4F8D875 https://serval.unil.ch/notice/serval:BIB_74465E4F8D87 https://serval.unil.ch/resource/serval:BIB_74465E4F8D87.P001/REF.pdf https://hdl.handle.net/11585/1009083 https://doi.org/10.1111/jsr.14365 https://onlinelibrary.wiley.com/doi/10.1111/jsr.14365 |
| Rights: | CC BY NC CC BY |
| Dokumentencode: | edsair.doi.dedup.....e8c6ea30d829c01a509df101b9afb356 |
| Datenbank: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstract: | SummaryThe aim of the present study was to examine gender and age‐specific effects on subjective daytime sleepiness (as measured by the Epworth Sleepiness Scale), body weight and eating behaviour in patients with central disorders of hypersomnolence. Based on the European Narcolepsy Network database, we compared 1035 patients with narcolepsy type I and 505 patients with other central disorders of hypersomnolence (“narcoleptic borderland”), including narcolepsy type II (N = 308) and idiopathic hypersomnia (N = 174), using logistic regression and general linear models. In the entire study population, the Epworth Sleepiness Scale was higher in women (N = 735, mean age = 30 years, mean Epworth Sleepiness Scale = 16.6 ± SD 3.9) than in men (N = 805, mean age = 32 years, mean Epworth Sleepiness Scale = 15.8 ± SD 4.4). In women with narcolepsy type I (N = 475), both Epworth Sleepiness Scale and body mass index increased in parallel with age. In women of the narcoleptic borderland (N = 260), the Epworth Sleepiness Scale markedly peaked in their early 30s, while body mass index only started to rise at that age. This rise in body mass index following the Epworth Sleepiness Scale peak cannot be explained by sleepiness‐induced uncontrolled eating, as self‐reported uncontrolled eating was negatively associated with the Epworth Sleepiness Scale in this group. We propose that the narcoleptic borderland harbours a unique cluster of women in their fertile years with an unexplored aetiology requiring further investigation towards tailored interventions. |
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| ISSN: | 13652869 09621105 |
| DOI: | 10.1111/jsr.14365 |