Neurodevelopmental effects of omega-3 fatty acids and its combination with Methylphenidate in iPSC models of ADHD
Gespeichert in:
| Titel: | Neurodevelopmental effects of omega-3 fatty acids and its combination with Methylphenidate in iPSC models of ADHD |
|---|---|
| Autoren: | Walter, Natalie M, Yde Ohki, Cristine M, Ruhstaller, Sina, Del Campana, Letizia, Salazar Campos, José Maria, Smigielski, Lukasz, Rubio, Belén, Walitza, Susanne, Grünblatt, Edna |
| Weitere Verfasser: | University of Zurich, Grünblatt, Edna |
| Quelle: | Journal of Psychiatric Research, 184 |
| Verlagsinformationen: | Elsevier BV, 2025. |
| Publikationsjahr: | 2025 |
| Schlagwörter: | Neural stem cells, 11558 Neuroscience Center Zurich, 610 Medicine & health, Wnt signaling, 2738 Psychiatry and Mental Health, Induced pluripotent stem cells, Attention-deficit/hyperactivity disorder, 11554 Zurich Center for Integrative Human Physiology (ZIHP), Growth rates, Polyunsaturated fatty acids, 10058 Child and Adolescent Psychiatry, Attention, 2803 Biological Psychiatry, deficit/hyperactivity disorder |
| Beschreibung: | Attention-Deficit/Hyperactivity Disorder (ADHD) has been linked to altered neurodevelopmental processes, including proliferation and differentiation of neural stem cells (NSC). We aimed to investigate the role of Wnt signaling, a pathway critical for brain development, in ADHD and to determine if modulation of this pathway using ω-3/6 polyunsaturated fatty acids (PUFAs) may provide a beneficial treatment approach. Given the symptom heterogeneity in ADHD and the limited response to conventional therapies for some patients, we examined the effects of ω-3/6 PUFA treatment combined with Methylphenidate (MPH) on neurodevelopmental mechanisms using induced pluripotent stem cell (iPSC)-derived NSCs, comparing controls to ADHD patients. Our results show that ω-3/6 PUFAs differentially regulate Wnt activity in NSCs depending on the patient's condition and the composition of the treatments. These findings highlight the potential of ω-3 PUFA treatment as personalized support for neurodevelopmental processes in ADHD. They also emphasize the importance of investigating ADHD subgroups, including those unresponsive to stimulant treatments, as they may exhibit distinct phenotypes. Journal of Psychiatric Research, 184 ISSN:0022-3956 ISSN:1879-1379 |
| Publikationsart: | Article Other literature type |
| Dateibeschreibung: | application/application/pdf; Walter_et_al_2025_Neurodevelopmental_effects_of_omega_3_fatty_acids_and_its_combination.pdf - application/pdf |
| Sprache: | English |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2025.02.035 |
| DOI: | 10.5167/uzh-276126 |
| DOI: | 10.3929/ethz-b-000726171 |
| Zugangs-URL: | https://pubmed.ncbi.nlm.nih.gov/40043588 http://hdl.handle.net/20.500.11850/726171 https://www.zora.uzh.ch/id/eprint/276126/ https://doi.org/10.5167/uzh-276126 |
| Rights: | CC BY |
| Dokumentencode: | edsair.doi.dedup.....e7fb07db373c50a8f55c1c53d9eb0a16 |
| Datenbank: | OpenAIRE |
Full Text Finder 
Nájsť tento článok vo Web of Science | Abstract: | Attention-Deficit/Hyperactivity Disorder (ADHD) has been linked to altered neurodevelopmental processes, including proliferation and differentiation of neural stem cells (NSC). We aimed to investigate the role of Wnt signaling, a pathway critical for brain development, in ADHD and to determine if modulation of this pathway using ω-3/6 polyunsaturated fatty acids (PUFAs) may provide a beneficial treatment approach. Given the symptom heterogeneity in ADHD and the limited response to conventional therapies for some patients, we examined the effects of ω-3/6 PUFA treatment combined with Methylphenidate (MPH) on neurodevelopmental mechanisms using induced pluripotent stem cell (iPSC)-derived NSCs, comparing controls to ADHD patients. Our results show that ω-3/6 PUFAs differentially regulate Wnt activity in NSCs depending on the patient's condition and the composition of the treatments. These findings highlight the potential of ω-3 PUFA treatment as personalized support for neurodevelopmental processes in ADHD. They also emphasize the importance of investigating ADHD subgroups, including those unresponsive to stimulant treatments, as they may exhibit distinct phenotypes.<br />Journal of Psychiatric Research, 184<br />ISSN:0022-3956<br />ISSN:1879-1379 |
|---|---|
| ISSN: | 00223956 |
| DOI: | 10.1016/j.jpsychires.2025.02.035 |