Magnetic resonance imaging findings at the first episode of acute optic neuritis
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| Názov: | Magnetic resonance imaging findings at the first episode of acute optic neuritis |
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| Autori: | Hanne Pernille Bro Skejoe, Friedemann Paul, Nasrin Asgari, Jakob Grauslund, Terry J. Smith, Søren Thue Lillevang, Brigitte Wildemann, Sven Jarius, Kerstin Soelberg |
| Zdroj: | Soelberg, K, Skejoe, H P B, Grauslund, J, Smith, T J, Lillevang, S T, Jarius, S, Wildemann, B, Paul, F & Asgari, N 2018, ' Magnetic resonance imaging findings at the first episode of acute optic neuritis ', Multiple Sclerosis and Related Disorders, vol. 20, pp. 30-36 . https://doi.org/10.1016/j.msard.2017.12.018 |
| Informácie o vydavateľovi: | Elsevier BV, 2018. |
| Rok vydania: | 2018 |
| Predmety: | Adult, Male, Optic Neuritis, Adolescent, Young Adult, 03 medical and health sciences, Spinal Cord/diagnostic imaging, 0302 clinical medicine, Brain Stem/diagnostic imaging, Optic Nerve/diagnostic imaging, Humans, Prospective Studies, Aged, Aquaporin 4, Optic Neuritis/blood, Optic Nerve, Aquaporin 4/immunology, Middle Aged, Magnetic Resonance Imaging, 3. Good health, Spinal Cord, Immunoglobulin G/blood, Immunoglobulin G, Acute Disease, Disease Progression, Female, Biomarkers/blood, Biomarkers, Brain Stem, Follow-Up Studies |
| Popis: | Optic neuritis (ON) is a focal demyelinating event, which may evolve into multiple sclerosis (MS).To study MRI characteristics in the acute phase of the first ON episode.A prospective population-based study was performed on 31 patients with a first episode of acute ON with a one year follow-up. MRI, clinical evaluation, and detection of aquaporin-4 (AQP4)-IgG and myelin oligodendrocyte glycoprotein (MOG)-IgG was undertaken. For lesion characterization on MRI the optic nerves were divided into three segments: intra-orbital (IO), canalicular (CAN) and chiasmal (CHI).Lesions of the optic nerve were observed in 80.6%(25/31), with IO location in 48%(12/25), CAN in 8% (2/25) and both IO and CAN in 44%(11/25). Patients who converted to MS had lesions located at IO in 77%(10/13), whereas the group with isolated ON had IO and CAN in 73% (8/11), p = 0.003. Brain lesions were observed in 84% (21/25) at onset of ON; 62%(13/25) progressed to MS with more frequent location in brainstem (p = 0.030) and lesions in periventricular areas (p = 0.015). Spinal cord lesions were detected only in patients who progressed to MS (p = 0.002). MOG-IgG was detected in one patient with an optic nerve lesion located at IO and CAN. Serum AQP4-IgG was detected in none. Follow-up MRI showed progression in optic nerve lesions in 55% (11/20) patients.Specific location of optic nerve and brain lesions and the presence of spinal cord lesions in the acute phase of the first ON episode facilitated an MS diagnosis. The extension of optic nerve lesions following ON suggests a long-term progressive degeneration as an important element of ON pathology. |
| Druh dokumentu: | Article |
| Popis súboru: | application/pdf |
| Jazyk: | English |
| ISSN: | 2211-0348 |
| DOI: | 10.1016/j.msard.2017.12.018 |
| Prístupová URL adresa: | https://findresearcher.sdu.dk:8443/ws/files/134398162/Magnetic_resonance_imaging_findings_at_the_first_episode_of_acute_optic_neuritis.pdf https://pubmed.ncbi.nlm.nih.gov/29291481 https://edoc.mdc-berlin.de/17004/ https://www.ncbi.nlm.nih.gov/pubmed/29291481 https://findresearcher.sdu.dk:8443/ws/files/134398162/Magnetic_resonance_imaging_findings_at_the_first_episode_of_acute_optic_neuritis.pdf http://findresearcher.sdu.dk/portal/files/134398162/Magnetic_resonance_imaging_findings_at_the_first_episode_of_acute_optic_neuritis.pdf https://pure-portal.regsj.dk/da/publications/magnetic-resonance-imaging-findings-at-the-first-episode-of-acute https://www.sciencedirect.com/science/article/abs/pii/S2211034817303577 https://portal.findresearcher.sdu.dk/da/publications/be9dae4b-495a-4ba1-ace3-495f4356811e https://doi.org/10.1016/j.msard.2017.12.018 |
| Rights: | Elsevier TDM CC BY NC ND |
| Prístupové číslo: | edsair.doi.dedup.....e7d6560e5017937fe9723651a3398b15 |
| Databáza: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | Optic neuritis (ON) is a focal demyelinating event, which may evolve into multiple sclerosis (MS).To study MRI characteristics in the acute phase of the first ON episode.A prospective population-based study was performed on 31 patients with a first episode of acute ON with a one year follow-up. MRI, clinical evaluation, and detection of aquaporin-4 (AQP4)-IgG and myelin oligodendrocyte glycoprotein (MOG)-IgG was undertaken. For lesion characterization on MRI the optic nerves were divided into three segments: intra-orbital (IO), canalicular (CAN) and chiasmal (CHI).Lesions of the optic nerve were observed in 80.6%(25/31), with IO location in 48%(12/25), CAN in 8% (2/25) and both IO and CAN in 44%(11/25). Patients who converted to MS had lesions located at IO in 77%(10/13), whereas the group with isolated ON had IO and CAN in 73% (8/11), p = 0.003. Brain lesions were observed in 84% (21/25) at onset of ON; 62%(13/25) progressed to MS with more frequent location in brainstem (p = 0.030) and lesions in periventricular areas (p = 0.015). Spinal cord lesions were detected only in patients who progressed to MS (p = 0.002). MOG-IgG was detected in one patient with an optic nerve lesion located at IO and CAN. Serum AQP4-IgG was detected in none. Follow-up MRI showed progression in optic nerve lesions in 55% (11/20) patients.Specific location of optic nerve and brain lesions and the presence of spinal cord lesions in the acute phase of the first ON episode facilitated an MS diagnosis. The extension of optic nerve lesions following ON suggests a long-term progressive degeneration as an important element of ON pathology. |
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| ISSN: | 22110348 |
| DOI: | 10.1016/j.msard.2017.12.018 |