The role of lipid emulsions containing omega-3 fatty acids for medical and surgical critical care patients
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| Název: | The role of lipid emulsions containing omega-3 fatty acids for medical and surgical critical care patients |
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| Autoři: | Stoppe, Christian, Martindale, Robert G., Klek, Stanislaw, Calder, Philip, Wischmeyer, Paul E., Patel, Jayshil J. |
| Zdroj: | Crit Care |
| Informace o vydavateli: | Springer Science and Business Media LLC, 2024. |
| Rok vydání: | 2024 |
| Témata: | 0301 basic medicine, Fat Emulsions, Intravenous, Parenteral Nutrition, 0303 health sciences, Critical Care, Brief Report, Critical Illness, 03 medical and health sciences, Fish Oils, Fatty Acids, Omega-3, Humans, Parenteral Nutrition/standards [MeSH], Consensus, Humans [MeSH], Guidelines, Critical illness, Fat Emulsions, Intravenous/therapeutic use [MeSH], Parenteral nutrition, Critical Care/methods [MeSH], Parenteral Nutrition/methods [MeSH], Fat Emulsions, Intravenous/administration, Fatty Acids, Omega-3/therapeutic use [MeSH], Critical Illness/therapy [MeSH], Acute Care Surgery [MeSH], Fish Oils/therapeutic use [MeSH], Lipids, Fish Oils/administration, Fatty Acids, Omega-3/administration, Omega 3, Acute Care Surgery |
| Popis: | In critical illness the regulation of inflammation and oxidative stress can improve patient outcomes, and thus omega-3 polyunsaturated fatty acids (PUFAs) have been used as part of parenteral nutrition (PN) owing to their potential anti-inflammatory effects. The international lipids in PN Summit, encompassed discussions and the production of consensus guidelines concerning PN intravenous lipid emulsion (ILE) use in critical care. The Lipid Summit participants agreed that the inclusion of fish oil in ILEs is associated with meaningful clinical benefits without signals of harm, based on a strong biological rationale and current clinical evidence. Decisions concerning ILE choice should be made based on current evidence, thus addressing clinical requirements for guidance, particularly as further definitive evidence seems unlikely to occur. In addition, a future of individualized ICU care is envisioned, yielding better clinical outcomes. This approach will require the greater use of intelligent study designs incorporating the use of biomarkers of omega-3 derivatives, inflammatory-resolving processes, and/or muscle protein breakdown. |
| Druh dokumentu: | Article Other literature type |
| Popis souboru: | text |
| Jazyk: | English |
| ISSN: | 1364-8535 |
| DOI: | 10.1186/s13054-024-05053-4 |
| Přístupová URL adresa: | https://pubmed.ncbi.nlm.nih.gov/39135117 https://repository.publisso.de/resource/frl:6505982 |
| Rights: | CC BY URL: http://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (http://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (http://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| Přístupové číslo: | edsair.doi.dedup.....e7c57ab1ee1d54b74dc27cb5c09933e1 |
| Databáze: | OpenAIRE |
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Nájsť tento článok vo Web of Science | Abstrakt: | In critical illness the regulation of inflammation and oxidative stress can improve patient outcomes, and thus omega-3 polyunsaturated fatty acids (PUFAs) have been used as part of parenteral nutrition (PN) owing to their potential anti-inflammatory effects. The international lipids in PN Summit, encompassed discussions and the production of consensus guidelines concerning PN intravenous lipid emulsion (ILE) use in critical care. The Lipid Summit participants agreed that the inclusion of fish oil in ILEs is associated with meaningful clinical benefits without signals of harm, based on a strong biological rationale and current clinical evidence. Decisions concerning ILE choice should be made based on current evidence, thus addressing clinical requirements for guidance, particularly as further definitive evidence seems unlikely to occur. In addition, a future of individualized ICU care is envisioned, yielding better clinical outcomes. This approach will require the greater use of intelligent study designs incorporating the use of biomarkers of omega-3 derivatives, inflammatory-resolving processes, and/or muscle protein breakdown. |
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| ISSN: | 13648535 |
| DOI: | 10.1186/s13054-024-05053-4 |