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Applicability of scoring systems predicting outcome of transarterial chemoembolization for hepatocellular carcinoma

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Title: Applicability of scoring systems predicting outcome of transarterial chemoembolization for hepatocellular carcinoma
Authors: Thomas Longerich, De Hua Chang, Karl Heinz Weiss, Isabelle Mohr, Uta Merle, S.D. Sprengel, Jan Pfeiffenberger, Arianeb Mehrabi, Marie Vogeler, Miriam Klauss, Andreas Teufel, Markus Mieth, Christoph Springfeld
Source: J Cancer Res Clin Oncol
Publisher Information: Springer Science and Business Media LLC, 2020.
Publication Year: 2020
Subject Terms: Adult, Male, Carcinoma, Hepatocellular, Original Article – Clinical Oncology, Severity of Illness Index, Carboplatin, Cohort Studies, 03 medical and health sciences, Ethiodized Oil, 0302 clinical medicine, Predictive Value of Tests, Germany, Humans, Chemoembolization, Therapeutic, Aged, Retrospective Studies, Aged, 80 and over, 2. Zero hunger, Carcinoma, Hepatocellular/mortality [MeSH], TACE, Aged, 80 and over [MeSH], Liver Neoplasms/mortality [MeSH], Aged [MeSH], Ethiodized Oil/administration, Liver Neoplasms/therapy [MeSH], Chemoembolization, Therapeutic/methods [MeSH], Carcinoma, Hepatocellular/therapy [MeSH], Germany/epidemiology [MeSH], Cohort Studies [MeSH], Male [MeSH], Liver cancer, Doxorubicin/administration, Chemoembolization, Therapeutic/statistics, Carboplatin/administration, Female [MeSH], Liver Neoplasms/diagnosis [MeSH], Adult [MeSH], Humans [MeSH], Severity of Illness Index [MeSH], Treatment Outcome [MeSH], Carcinoma, Hepatocellular/diagnosis [MeSH], Predictive Value of Tests [MeSH], Retrospective Studies [MeSH], Middle Aged [MeSH], Stage migration, Survival Rate [MeSH], Liver Transplantation/statistics, Embolization, Liver Transplantation/methods [MeSH], Liver Neoplasms, Middle Aged, Liver Transplantation, 3. Good health, Survival Rate, Doxorubicin, Female
Description: Purpose Several scoring systems have been proposed to predict the outcome of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). However, the application of these scores to a bridging to transplant setting is poorly validated. Evaluation of the applicability of prognostic scores for patients undergoing TACE in palliative intention vs. bridging therapy to liver transplantation (LT) is necessary. Methods Between 2008 and 2017, 148 patients with HCC received 492 completed TACE procedures (158 for bridging to transplant; 334 TACE procedures in palliative treatment intention at our center and were analyzed retrospectively. Scores (ART, CLIP, ALBI, APRI, SNACOR, HAP, STATE score, Child–Pugh, MELD, Okuda and BCLC) were calculated and evaluated for prediction of overall survival. ROC analysis was performed to assess prediction of 3-year survival and treatment discontinuation. Results In patients receiving TACE in palliative intention most scores predicted OS in univariate analysis but only mSNACOR score (p = 0.006), State score (p p p = 0.002). Conclusions Clinical usability of suggested scoring systems for TACE might be limited depending on the individual patient cohorts and the indication. Especially in patients receiving TACE as bridging to LT none of the scores showed sufficiently applicability. In our study Child–Pugh score, STATE score and mSNACOR score showed the best performance assessing OS in patients with TACE as palliative therapy.
Document Type: Article
Other literature type
Language: English
ISSN: 1432-1335
0171-5216
DOI: 10.1007/s00432-020-03135-8
Access URL: https://link.springer.com/content/pdf/10.1007/s00432-020-03135-8.pdf
https://pubmed.ncbi.nlm.nih.gov/32107625
https://link.springer.com/content/pdf/10.1007/s00432-020-03135-8.pdf
https://pubmed.ncbi.nlm.nih.gov/32107625/
https://www.ncbi.nlm.nih.gov/pubmed/32107625
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085483
https://link.springer.com/article/10.1007/s00432-020-03135-8
https://www.mendeley.com/catalogue/4b887647-d3a7-3548-abf3-5b34db287b01/
https://repository.publisso.de/resource/frl:6467684
Rights: CC BY
Accession Number: edsair.doi.dedup.....e7483bba8ec05dd7edb18499b0acdedc
Database: OpenAIRE
Description
Abstract:Purpose Several scoring systems have been proposed to predict the outcome of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). However, the application of these scores to a bridging to transplant setting is poorly validated. Evaluation of the applicability of prognostic scores for patients undergoing TACE in palliative intention vs. bridging therapy to liver transplantation (LT) is necessary. Methods Between 2008 and 2017, 148 patients with HCC received 492 completed TACE procedures (158 for bridging to transplant; 334 TACE procedures in palliative treatment intention at our center and were analyzed retrospectively. Scores (ART, CLIP, ALBI, APRI, SNACOR, HAP, STATE score, Child–Pugh, MELD, Okuda and BCLC) were calculated and evaluated for prediction of overall survival. ROC analysis was performed to assess prediction of 3-year survival and treatment discontinuation. Results In patients receiving TACE in palliative intention most scores predicted OS in univariate analysis but only mSNACOR score (p = 0.006), State score (p p p = 0.002). Conclusions Clinical usability of suggested scoring systems for TACE might be limited depending on the individual patient cohorts and the indication. Especially in patients receiving TACE as bridging to LT none of the scores showed sufficiently applicability. In our study Child–Pugh score, STATE score and mSNACOR score showed the best performance assessing OS in patients with TACE as palliative therapy.
ISSN:14321335
01715216
DOI:10.1007/s00432-020-03135-8